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PubMed Publications| Keyword search (4,163 papers available) |  |
"White matter" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Variations in perfusion detectable in advance of microstructure in white matter aging | Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ; | 40694306 PHYSICS |
| 2 | Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions | Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM; | 40585093 PSYCHOLOGY |
| 3 | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 40086421 PSYCHOLOGY |
| 4 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 5 | Music reward sensitivity is associated with greater information transfer capacity within dorsal and motor white matter networks in musicians | Matthews TE; Lumaca M; Witek MAG; Penhune VB; Vuust P; | 39052097 PSYCHOLOGY |
| 6 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 7 | Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease | Xiao Y; Peters TM; Khan AR; | 34106502 PERFORM |
| 8 | White matter microstructural changes in short-term learning of a continuous visuomotor sequence | Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; | 33885965 PERFORM |
| 9 | The descending motor tracts are different in dancers and musicians. | Giacosa C, Karpati FJ, Foster NEV, Hyde KL, Penhune VB | 31620887 PSYCHOLOGY |
| 10 | Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study. | Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E | 31507359 PERFORM |
| 11 | Arterial stiffness and brain integrity: A review of MRI findings. | Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ | 31063866 PERFORM |
| Title: | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | ||||
| Authors: | Tremblay SA, Nathan Spreng R, Wearn A, Alasmar Z, Pirhadi A, Tardif CL, Chakravarty MM, Villeneuve S, Leppert IR, Carbonell F, Medina YI, Steele CJ, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40086421/ | ||||
| DOI: | 10.1016/j.neurobiolaging.2025.03.003 | ||||
| Publication: | Neurobiology of aging | ||||
| Keywords: | APOE4; Cardiometabolic risk factors; Familial history; LDL-cholesterol; Myelin; Sex differences; White matter; | ||||
| PMID: | 40086421 | Category: | Date Added: | 2025-03-15 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Physics department, Concordia University, 7141 Rue Sherbrooke W, Montréal, QC H4B 1R6, Canada; Montreal Heart Institute, 5000 Rue Bélanger, Montréal, QC H1T 1C8, Canada; School of Health, Concordia University, 7200 Rue Sherbrooke W, Montréal, QC H4B 1R6, Canada. Electronic address: stefanie.tremblay@mail.concordia.ca. 2 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada; Department of Psychiatry, McGill University, 845 Rue Sherbrooke W, Montréal, QC H3A 0G4, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, 845 Rue Sherbrooke W, Montréal, QC H3A 0G4, Canada; StoP-AD Centre, Douglas Mental Health Institute Research Centre, 6875 Blvd. LaSalle, Verdun, QC H4H 1R3, Canada. 3 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada. 4 School of Health, Concordia University, 7200 Rue Sherbr |
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Description: |
Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming to prevent progression will likely be most effective when initiated early. White matter (WM) alterations are among the earliest changes in AD, yet limited work has comprehensively characterized the effects of AD risk factors on WM. In older adults with a family history of AD, we investigated the sex-specific and APOE genotype-related relationships between WM microstructure and risk factors. Multiple MRI-derived metrics were integrated using a multivariate approach based on the Mahalanobis distance (D2). To uncover the specific biological underpinnings of these WM alterations, we then extracted the contribution of each MRI feature to D2 in significant clusters. Lastly, the links between WM D2 and cognition were explored. WM D2 in several regions was associated with high systolic blood pressure, BMI, and glycated hemoglobin, and low cholesterol, in both males and females. APOE4 + displayed a distinct risk pattern, with LDL-cholesterol having a detrimental effect only in carriers, and this pattern was linked to immediate memory performance. Myelination was the main mechanism underlying WM alterations. Our findings reveal that combined exposure to multiple cardiometabolic risk factors negatively impacts microstructural health, which may subsequently affect cognition. Notably, APOE4 carriers exhibited a different risk pattern, especially in the role of LDL, suggesting distinct underlying mechanisms in this group. |
