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PubMed Publications| Keyword search (4,163 papers available) |  |
"Gauthier CJ" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | Biomarkers | Zhou J; Wearn A; Huck J; Hughes CS; Baracchini G; Sylvain E; Tremblay-Mercier J; Poirier J; Breitner JCSCS; Villeneuve S; Chakravarty MM; Tardif CL; Gauthier CJ; Daugherty AM; Turner GR; Spreng RN; | 41499788 ENCS |
| 4 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 5 | Alzheimer s Imaging Consortium | Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ; | 41433411 CONCORDIA |
| 6 | Public Health | Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ; | 41435069 CONCORDIA |
| 7 | Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition | Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ; | 41353310 SOH |
| 8 | The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterbe | 41020412 SOH |
| 9 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 10 | The PREVENT-AD cohort: accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Valdez AF; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterberg H; S | 40778177 PSYCHOLOGY |
| 11 | Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | Farahani A; Liu ZQ; Ceballos EG; Hansen JY; Wennberg K; Zeighami Y; Dadar M; Gauthier CJ; Dagher A; Misic B; | 40729400 PHYSICS |
| 12 | Assessing quantitative MRI techniques using multimodal comparisons | Carter F; Anwander A; Johnson M; Goucha T; Adamson H; Friederici AD; Lutti A; Gauthier CJ; Weiskopf N; Bazin PL; Steele CJ; | 40705745 SOH |
| 13 | Variations in perfusion detectable in advance of microstructure in white matter aging | Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ; | 40694306 PHYSICS |
| 14 | Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer s disease | Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None; | 40347524 CONCORDIA |
| 15 | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 40086421 PSYCHOLOGY |
| 16 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 40079560 SOH |
| 17 | Alzheimer's Imaging Consortium | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39782998 CONCORDIA |
| 18 | Biomarkers | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39785351 CONCORDIA |
| 19 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 39416007 SOH |
| 20 | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | Wearn A; Tremblay SA; Tardif CL; Leppert IR; Gauthier CJ; Baracchini G; Hughes C; Hewan P; Tremblay-Mercier J; Rosa-Neto P; Poirier J; Villeneuve S; Schmitz TW; Turner GR; Spreng RN; | 38830849 SOH |
| 21 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 22 | Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease | Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauthier CJ; Turner GR; Spreng RN; | 38388425 PSYCHOLOGY |
| 23 | Decreased long-range temporal correlations in the resting-state functional magnetic resonance imaging blood-oxygen-level-dependent signal reflect motor sequence learning up to 2 weeks following training | Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ; | 38124341 SOH |
| 24 | Modeling venous bias in resting state functional MRI metrics | Huck J; Jäger AT; Schneider U; Grahl S; Fan AP; Tardif C; Villringer A; Bazin PL; Steele CJ; Gauthier CJ; | 37498014 PERFORM |
| 25 | Cerebral blood flow in schizophrenia: A systematic review and meta-analysis of MRI-based studies | Percie du Sert O; Unrau J; Gauthier CJ; Chakravarty M; Malla A; Lepage M; Raucher-Chéné D; | 36341843 CRDH |
| 26 | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study | Jäger AP; Huntenburg JM; Tremblay SA; Schneider U; Grahl S; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ; | 34704176 PERFORM |
| 27 | Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults | Sabra D; Intzandt B; Desjardins-Crepeau L; Langeard A; Steele CJ; Frouin F; Hoge RD; Bherer L; Gauthier CJ; | 34582484 PERFORM |
| 28 | Comparing the effect of Cognitive vs. Exercise Training on brain MRI outcomes in healthy older adults: A systematic review | Intzandt B; Vrinceanu T; Huck J; Vincent T; Montero-Odasso M; Gauthier CJ; Bherer L; | 34245760 PERFORM |
| 29 | White matter microstructural changes in short-term learning of a continuous visuomotor sequence | Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; | 33885965 PERFORM |
| 30 | A Cross-Sectional Study on the Impact of Arterial Stiffness on the Corpus Callosum, a Key White Matter Tract Implicated in Alzheimer's Disease | Badji A; de la Colina AN; Boshkovski T; Sabra D; Karakuzu A; Robitaille-Grou MC; Gros C; Joubert S; Bherer L; Lamarre-Cliche M; Stikov N; Gauthier CJ; Cohen-Adad J; Girouard H; | 32741837 PERFORM |
| 31 | BOLD signal physiology: Models and applications. | Gauthier CJ, Fan AP | 29544818 IMAGING |
| 32 | High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps. | Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ | 31278570 PSYCHOLOGY |
| 33 | Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults. | Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ | 31342831 PERFORM |
| 34 | Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity. | Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A | 26318050 PERFORM |
| 35 | Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke. | Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ | 30732551 PHYSICS |
| 36 | Arterial stiffness and brain integrity: A review of MRI findings. | Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ | 31063866 PERFORM |
| 37 | Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. | Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L | 25741267 PERFORM |
| 38 | Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies. | Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ | 28159689 PERFORM |
| 39 | Age differences in brain signal variability are robust to multiple vascular controls. | Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ | 28860455 PERFORM |
| Title: | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | ||||
| Authors: | Wearn A, Tremblay SA, Tardif CL, Leppert IR, Gauthier CJ, Baracchini G, Hughes C, Hewan P, Tremblay-Mercier J, Rosa-Neto P, Poirier J, Villeneuve S, Schmitz TW, Turner GR, Spreng RN | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38830849/ | ||||
| DOI: | 10.1038/s41467-024-48490-z | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 38830849 | Category: | Date Added: | 2024-06-04 | |
| Dept Affiliation: |
SOH
1 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. alfie.wearn@mcgill.ca. 2 Department of Physics, Concordia University, Montreal, H4B 1R6, QC, Canada. 3 Montreal Heart Institute, Montreal, H1T 1C8, QC, Canada. 4 School of Health, Concordia University, Montreal, H4B 1R6, QC, Canada. 5 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. 6 McConnell Brain Imaging Centre, McGill University, Montreal, H3A 2B4, QC, Canada. 7 Department of Biomedical Engineering, McGill University, McGill, H3A 2B4, QC, Canada. 8 Department of Psychology, York University, Toronto, M3J 1P3, ON, Canada. 9 Douglas Mental Health University Institute-Research Center, Verdun, H4H 1R3, QC, Canada. 10 Department of Psychiatry, McGill University, Montreal, H3A 1A1, QC, Canada. 11 Department of Physiology & Pharmacology, Western Institute for Neuroscience, Western University, London, N6A 5C1, ON, Canada. 12 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. nathan.spreng@mcgill.ca. 13 McConnell Brain Imaging Centre, McGill University, Montreal, H3A 2B4, QC, Canada. nathan.spreng@mcgill.ca. 14 Douglas Mental Health University Institute-Research Center, Verdun, H4H 1R3, QC, Canada. nathan.spreng@mcgill.ca. 15 Department of Psychiatry, McGill University, Montreal, H3A 1A1, QC, Canada. nathan.spreng@mcgill.ca. |
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Description: |
The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's white matter. We investigated the relationship between IdC microstructure and whole-brain white matter microstructure to better understand early neuropathological changes in AD. Using multiparametric quantitative magnetic resonance imaging we observed two covariance patterns between IdC and white matter microstructure in 133 cognitively unimpaired older adults (age 67.9 ± 5.3 years) with familial risk for AD. IdC integrity related to 1) whole-brain neurite density, and 2) neurite orientation dispersion in white matter tracts known to be affected early in AD. Pattern 2 was associated with CSF concentration of phosphorylated-tau, indicating AD specificity. Apolipoprotein-E4 carriers expressed both patterns more strongly than non-carriers. IdC microstructure variation is reflected in white matter, particularly in AD-affected tracts, highlighting an early mechanism of pathological development. |
