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PubMed Publications| Keyword search (4,163 papers available) |  |
Newest Concordia Publications (of 75):
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner | Gholizadeh F; Hajiaghayi M; Rahbari N; Choi JS; Heidt S; Como A; Kazerouni M; Kargar M; Pinard-LaRoche A; Shih SCC; Darlington PJ; | 41928597 SOH |
| 2 | Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner | Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ; | 41906691 SOH |
| 3 | Strengthening and Targeted Rehabilitation for Optimal Neuromuscular Gains for chronic BACK pain (STRONG-BACK): protocol for a randomised controlled trial in participants with primary nociceptive pain drivers | Fortin M; Rosenstein B; Bertrand C; Vaillancourt N; Wright A; Montpetit C; Macedo L; Elliott J; Cook CE; Tousignant-Laflamme Y; Ma J; Pagé MG; Dover G; Dang-Vu TT; Weber MH; | 41876162 SOH |
| 4 | A Fully Virtual Graded Exertion Test Is Safe and Feasible in Symptomatic and Asymptomatic Children With Concussion | Coupal J; Shabanova D; Gagnon I; Grilli L; Beaulieu C; Teel E; | 41816309 SOH |
| 5 | Achilles tendon ultrasound-derived properties of the dominant and non-dominant jumping leg of university basketball athletes: relation with performance, range of motion, and injury | Soontjens O; Busner J; Fortin M; | 41783785 SOH |
| 6 | Exploring correlates of weight bias among university students in diverse programs | Jeanningros A; Côté M; Forouhar V; Aimé A; Lavallière M; Blackburn P; Maïano C; Alberga AS; Baillot A; | 41718586 SOH |
| 7 | Beyond the wound: A scoping review of the psychosocial impact of diabetes-related foot ulcers | Hanlon M; McGuire BE; MacGilchrist C; Kirwan E; Neachtain DN; Dhatariya K; Blanchette V; Durand H; Dragomir A; McIntosh C; | 41721498 SOH |
| 8 | The effect of postoperative rehabilitation on outcomes in patients with degenerative cervical myelopathy (DCM): A systematic review | Montpetit C; Kobaisi A; Lantz JM; Chauhan RV; Anderson DB; Fortin M; | 41693706 SOH |
| 9 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 10 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 11 | The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 41688421 SOH |
| 12 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 13 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 14 | Aquatic therapy compared to standard care for chronic low back pain: a randomized controlled trial | Vaillancourt N; Montpetit C; Rosenstein B; Fortin M; | 41527881 SOH |
| 15 | The ELEVATE-LBP consortium: exercise &, evidence to lead effective vital action in translating excellence for low back pain prevention | Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J; | 41507623 SOH |
| Title: | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | ||||
| Authors: | Sanami S, Tremblay SA, Potvin-Jutras Z, Rezaei A, Sabra D, Gagnon C, Intzandt B, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41680492/ | ||||
| DOI: | 10.1007/s11357-026-02128-8 | ||||
| Publication: | GeroScience | ||||
| Keywords: | Cardiorespiratory fitness; Cerebral blood flow; Cerebral metabolic rate of oxygen; Cerebrovascular reactivity; Coronary artery disease; Oxygen extraction fraction; | ||||
| PMID: | 41680492 | Category: | Date Added: | 2026-02-13 | |
| Dept Affiliation: |
SOH
1 Physics Department, Concordia University, SP Building, Room 367.067141 Sherbrooke St. W, Montreal, QC, H4B 1R6, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, H1T 1N6, Canada. 3 School of Health, Concordia University, Montreal, QC, H4B 1R6, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, H2V 0B3, Canada. 5 Kinesiology & Health Science, Faculty of Health, York University, Toronto, ON, M3J 1P3, Canada. 6 Dr Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, H4B 1R6, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, H2V 0B3, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, H2V 0B3, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, H3W 1W5, Canada. 11 Physics Department, Concordia University, SP Building, Room 367.067141 Sherbrooke St. W, Montreal, QC, H4B 1R6, Canada. claudine.gauthier@concordia.ca. 12 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, H1T 1N6, Canada. claudine.gauthier@concordia.ca. 13 School of Health, Concordia University, Montreal, QC, H4B 1R6, Canada. claudine.gauthier@concordia.ca. |
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Description: |
This study investigated whether higher cardiorespiratory fitness (VO2peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF) across healthy older adults and patients with coronary artery disease (CAD). Thirty-seven healthy adults (65.3 ± 8.3 years old) and 35 CAD patients (66.4 ± 9.3 years old) underwent calibrated fMRI using hypercapnic and hyperoxic gas challenges (including carbogen) to quantify gray matter CBF, CVR, CMRO2, and OEF. VO2peak was obtained from a maximal cycle ergometer cardiopulmonary exercise test. Associations between VO2peak and brain biomarkers were evaluated with group terms to test CAD-specific effects. Across all participants, VO2peak was positively associated with CBF (ß = 0.32, p = 0.02) and CVR (ß = 0.002, p = 0.04) in gray matter, indicating an association between aerobic fitness and vascular health. Metabolic effects differed by group: in CAD patients, VO2peak correlated positively with CMRO2 (ß = 0.08, p = 0.02), suggesting higher fitness may be associated with preserved oxidative metabolism, while in healthy controls, VO2peak was negatively associated with OEF (ß = -3.6, p = 0.02), consistent with aging-related adaptations driven by improved CBF without CMRO2 changes. VO2peak is positively associated with cerebral vascular function in older adults and shows group-specific metabolic benefits: in CAD, higher VO2peak relates to preserved CMRO2, whereas in healthy individuals it is linked primarily to enhanced perfusion and reduced extraction. These findings support aerobic exercise as a promising strategy to mitigate CAD-related brain alterations and highlight VO2peak as a potentially modifiable target for prevention and rehabilitation. |
