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PubMed Publications| Keyword search (4,163 papers available) |  |
"Tremblay SA" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 4 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 5 | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 40086421 PSYCHOLOGY |
| 6 | Alzheimer's Imaging Consortium | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39782998 CONCORDIA |
| 7 | Biomarkers | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39785351 CONCORDIA |
| 8 | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | Wearn A; Tremblay SA; Tardif CL; Leppert IR; Gauthier CJ; Baracchini G; Hughes C; Hewan P; Tremblay-Mercier J; Rosa-Neto P; Poirier J; Villeneuve S; Schmitz TW; Turner GR; Spreng RN; | 38830849 SOH |
| 9 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 10 | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study | Jäger AP; Huntenburg JM; Tremblay SA; Schneider U; Grahl S; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ; | 34704176 PERFORM |
| 11 | White matter microstructural changes in short-term learning of a continuous visuomotor sequence | Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; | 33885965 PERFORM |
| 12 | State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis. | Tremblay SA, Chapman CA, Courtemanche R | 31736718 HKAP |
| Title: | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | ||||
| Authors: | Wearn A, Tremblay SA, Tardif CL, Leppert IR, Gauthier CJ, Baracchini G, Hughes C, Hewan P, Tremblay-Mercier J, Rosa-Neto P, Poirier J, Villeneuve S, Schmitz TW, Turner GR, Spreng RN | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38830849/ | ||||
| DOI: | 10.1038/s41467-024-48490-z | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 38830849 | Category: | Date Added: | 2024-06-04 | |
| Dept Affiliation: |
SOH
1 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. alfie.wearn@mcgill.ca. 2 Department of Physics, Concordia University, Montreal, H4B 1R6, QC, Canada. 3 Montreal Heart Institute, Montreal, H1T 1C8, QC, Canada. 4 School of Health, Concordia University, Montreal, H4B 1R6, QC, Canada. 5 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. 6 McConnell Brain Imaging Centre, McGill University, Montreal, H3A 2B4, QC, Canada. 7 Department of Biomedical Engineering, McGill University, McGill, H3A 2B4, QC, Canada. 8 Department of Psychology, York University, Toronto, M3J 1P3, ON, Canada. 9 Douglas Mental Health University Institute-Research Center, Verdun, H4H 1R3, QC, Canada. 10 Department of Psychiatry, McGill University, Montreal, H3A 1A1, QC, Canada. 11 Department of Physiology & Pharmacology, Western Institute for Neuroscience, Western University, London, N6A 5C1, ON, Canada. 12 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada. nathan.spreng@mcgill.ca. 13 McConnell Brain Imaging Centre, McGill University, Montreal, H3A 2B4, QC, Canada. nathan.spreng@mcgill.ca. 14 Douglas Mental Health University Institute-Research Center, Verdun, H4H 1R3, QC, Canada. nathan.spreng@mcgill.ca. 15 Department of Psychiatry, McGill University, Montreal, H3A 1A1, QC, Canada. nathan.spreng@mcgill.ca. |
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Description: |
The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's white matter. We investigated the relationship between IdC microstructure and whole-brain white matter microstructure to better understand early neuropathological changes in AD. Using multiparametric quantitative magnetic resonance imaging we observed two covariance patterns between IdC and white matter microstructure in 133 cognitively unimpaired older adults (age 67.9 ± 5.3 years) with familial risk for AD. IdC integrity related to 1) whole-brain neurite density, and 2) neurite orientation dispersion in white matter tracts known to be affected early in AD. Pattern 2 was associated with CSF concentration of phosphorylated-tau, indicating AD specificity. Apolipoprotein-E4 carriers expressed both patterns more strongly than non-carriers. IdC microstructure variation is reflected in white matter, particularly in AD-affected tracts, highlighting an early mechanism of pathological development. |
