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PubMed Publications| Keyword search (4,163 papers available) |  |
"Li KZH" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 2 | Tuned to walk: cue type, beat perception, and gait dynamics during rhythmic stimulation in aging | Parker A; Dalla Bella S; Penhune VB; Young L; Grenet D; Li KZH; | 41661338 PSYCHOLOGY |
| 3 | Auditory Training for Everyday Functioning in Later Life | Li KZH; Campos J; Pichora-Fuller MK; | 41036263 PSYCHOLOGY |
| 4 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 5 | Realistic dual-task listening-while-balancing in older adults with normal hearing and hearing loss with and without hearing aids | Mohanathas N; Montanari L; Gabriel GA; Downey R; Li KZH; Campos JL; | 39567644 PERFORM |
| 6 | Exploring the challenges of avoiding collisions with virtual pedestrians using a dual-task paradigm in individuals with chronic moderate to severe traumatic brain injury | de Aquino Costa Sousa T; Gagnon IJ; Li KZH; McFadyen BJ; Lamontagne A; | 38755606 PERFORM |
| 7 | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; | 37471089 PERFORM |
| 8 | The association between information and communication technologies, loneliness and social connectedness: A scoping review | Petersen B; Khalili-Mahani N; Murphy C; Sawchuk K; Phillips N; Li KZH; Hebblethwaite S; | 37034933 PSYCHOLOGY |
| 9 | Multiple routes to help you roam: A comparison of training interventions to improve cognitive-motor dual-tasking in healthy older adults | Downey R; Bherer L; Pothier K; Vrinceanu T; Intzandt B; Berryman N; Lussier M; Vincent T; Karelis AD; Nigam A; Vu TTM; Bosquet L; Li KZH; | 36408116 PERFORM |
| 10 | Sex-Related Differences in the Associations Between Montreal Cognitive Assessment Scores and Pure-Tone Measures of Hearing | Al-Yawer F; Bruce H; Li KZH; Pichora-Fuller MK; Phillips NA; | 35226818 PERFORM |
| 11 | A comparison of the effect of physical activity and cognitive training on dual-task performance in older adults | Vrinceanu T; Blanchette CA; Intzandt B; Lussier M; Pothier K; Vu TTM; Nigam A; Bosquet L; Karelis AD; Li KZH; Berryman N; Bherer L; | 34865009 PERFORM |
| 12 | A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults | Pothier K; Vrinceanu T; Intzandt B; Bosquet L; Karelis AD; Lussier M; Vu TTM; Nigam A; Li KZH; Berryman N; Bherer L; | 33774144 PERFORM |
| 13 | Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study. | Pieruccini-Faria F, Black SE, Masellis M, Smith EE, Almeida QJ, Li KZH, Bherer L, Camicioli R, Montero-Odasso M | 33590967 PSYCHOLOGY |
| 14 | Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults | Bherer L; Gagnon C; Langeard A; Lussier M; Desjardins-Crépeau L; Berryman N; Bosquet L; Vu TTM; Fraser S; Li KZH; Kramer AF; | 32803232 PERFORM |
| 15 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| 16 | The Effects of Age and Hearing Loss on Dual-Task Balance and Listening. | Bruce H, Aponte D, St-Onge N, Phillips N, Gagné JP, Li KZH | 28486677 PERFORM |
| 17 | A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. | Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L | 29235076 PERFORM |
| 18 | Cognitive Involvement in Balance, Gait and Dual-Tasking in Aging: A Focused Review From a Neuroscience of Aging Perspective | Li KZH; Bherer L; Mirelman A; Maidan I; Hausdorff JM; | 30425679 PERFORM |
| Title: | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | ||||
| Authors: | Montero-Odasso M, Zou G, Speechley M, Almeida QJ, Liu-Ambrose T, Middleton LE, Camicioli R, Bray NW, Li KZH, Fraser S, Pieruccini-Faria F, Berryman N, Lussier M, Shoemaker JK, Son S, Bherer L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/37471089/ | ||||
| DOI: | 10.1001/jamanetworkopen.2023.24465 | ||||
| Publication: | JAMA network open | ||||
| Keywords: | |||||
| PMID: | 37471089 | Category: | Date Added: | 2023-07-20 | |
| Dept Affiliation: |
PERFORM
1 Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, Ontario, Canada. 2 Department of Medicine, Division of Geriatric, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. 3 Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada. 4 Robarts Research Institute, University of Western Ontario, London, Ontario, Canada. 5 Carespace Health & Wellness, Waterloo, Ontario, Canada. 6 Movement Disorders Research & Rehabilitation Centre, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, Ontario, Canada. 7 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada. 8 Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada. 9 Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada. 10 School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. 11 PERFORM Centre and Department of Psychology, Concordia University, Montréal, Quebec, Canada. 12 Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, Ontario, Canada. 13 Département des sciences de l'activité physique Université du Québec à Montréal, Montréal, Quebec, Canada. 14 Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada. 15 Integrated Health and Social Services University Network for South-Central Montreal, Montreal, Quebec, Canada. 16 Research Centre, Montreal Heart Institute, and Department of Medicine, University of Montréal, Montréal, Quebec, Canada. |
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Description: |
Importance: Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI). Objective: To determine whether aerobic-resistance exercises would improve cognition relative to an active control and if a multidomain intervention including exercises, computerized cognitive training, and vitamin D supplementation would show greater improvements than exercise alone. Design, setting, and participants: This randomized clinical trial (the SYNERGIC Study) was a multisite, double-masked, fractional factorial trial that evaluated the effects of aerobic-resistance exercise, computerized cognitive training, and vitamin D on cognition. Eligible participants were between ages 65 and 84 years with MCI enrolled from September 19, 2016, to April 7, 2020. Data were analyzed from February 2021 to December 2022. Interventions: Participants were randomized to 5 study arms and treated for 20 weeks: arm 1 (multidomain intervention with exercise, cognitive training, and vitamin D), arm 2 (exercise, cognitive training, and placebo vitamin D), arm 3 (exercise, sham cognitive training, and vitamin D), arm 4 (exercise, sham cognitive training, and placebo vitamin D), and arm 5 (control group with balance-toning exercise, sham cognitive training, and placebo vitamin D). The vitamin D regimen was a 10 000 IU dose 3 times weekly. Main outcomes and measures: Primary outcomes were changes in ADAS-Cog-13 and Plus variant at 6 months. Results: Among 175 randomized participants (mean [SD] age, 73.1 [6.6] years; 86 [49.1%] women), 144 (82%) completed the intervention and 133 (76%) completed the follow-up (month 12). At 6 months, all active arms (ie, arms 1 through 4) with aerobic-resistance exercise regardless of the addition of cognitive training or vitamin D, improved ADAS-Cog-13 when compared with control (mean difference, -1.79 points; 95% CI, -3.27 to -0.31 points; P = .02; d = 0.64). Compared with exercise alone (arms 3 and 4), exercise and cognitive training (arms 1 and 2) improved the ADAS-Cog-13 (mean difference, -1.45 points; 95% CI, -2.70 to -0.21 points; P = .02; d = 0.39). No significant improvement was found with vitamin D. Finally, the multidomain intervention (arm 1) improved the ADAS-Cog-13 score significantly compared with control (mean difference, -2.64 points; 95% CI, -4.42 to -0.80 points; P = .005; d = 0.71). Changes in ADAS-Cog-Plus were not significant. Conclusions and relevance: In this clinical trial, older adults with MCI receiving aerobic-resistance exercises with sequential computerized cognitive training significantly improved cognition, although some results were inconsistent. Vitamin D supplementation had no effect. Our findings suggest that this multidomain intervention may improve cognition and potentially delay dementia onset in MCI. Trial registration: ClinicalTrials.gov Identifier: NCT02808676. |
