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PubMed Publications| Keyword search (4,163 papers available) |  |
"Gagnon C" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 4 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 5 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 6 | Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol | Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau-Majeau F; Blanchette CA; Vitali P; Nigam A; | 40625372 PSYCHOLOGY |
| 7 | Psychometric Properties of a French Version of the Perceived Motor Competence in Childhood Questionnaire | Maïano C; Morin AJS; April J; Tietjens M; St-Jean C; Gagnon C; Dreiskämper D; Aimé A; | 33765895 PSYCHOLOGY |
| 8 | Validation of an Adapted Version of the Glasgow Anxiety Scale for People with Intellectual Disabilities (GAS-ID) | Maïano C; Morin AJS; Gagnon C; Olivier E; Tracey D; Craven RG; Bouchard S; | 35138559 PSYCHOLOGY |
| 9 | Validation of a Revised Version of the Center for Epidemiologic Depression Scale for Youth with Intellectual Disabilities (CESD-ID-R) | Olivier E; Lacombe C; Morin AJS; Houle SA; Gagnon C; Tracey D; Craven RG; Maïano C; | 34716523 PSYCHOLOGY |
| 10 | A psychometric validation of the motives for physical activity measure for youth with intellectual disabilities (MPAM-ID) | Maïano C; Morin AJS; Tracey D; Gagnon C; Smodis McCune V; Craven RG; | 34528859 PSYCHOLOGY |
| 11 | Development and Validation of a Multi-informant Measure of Social Behaviors for Youth with Intellectual Disabilities | Olivier E; Morin AJS; Tracey D; Verma N; Dubé C; Gagnon C; Craven RG; Maïano C; | 34255229 PSYCHOLOGY |
| 12 | Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults | Bherer L; Gagnon C; Langeard A; Lussier M; Desjardins-Crépeau L; Berryman N; Bosquet L; Vu TTM; Fraser S; Li KZH; Kramer AF; | 32803232 PERFORM |
| 13 | A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. | Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L | 29235076 PERFORM |
| Title: | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | ||||
| Authors: | Sanami S, Rezaei A, Tremblay SA, Potvin-Jutras Z, Sabra D, Intzandt B, Gagnon C, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41543005/ | ||||
| DOI: | 10.1177/0271678X251413924 | ||||
| Publication: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | ||||
| Keywords: | Cerebral blood flow; cerebral metabolic rate of oxygen consumption; dual calibrated functional MRI; oxygen extraction fraction; quantitative susceptibility mapping; | ||||
| PMID: | 41543005 | Category: | Date Added: | 2026-01-16 | |
| Dept Affiliation: |
SOH
1 Department of Physics, Concordia University, Montreal, QC, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, Canada. 3 School of Health, Concordia University, Montreal, QC, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada. 5 BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada. 6 Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada. |
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Description: |
Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain health, particularly higher gray matter volume and perfusion. The brain relies heavily on oxidative metabolism, yet the relationship between cardiorespiratory fitness and brain oxidative metabolism remains underexplored. This study investigated the association between VO2peak and two key cerebral metabolic parameters: the cerebral metabolic rate of oxygen consumption (CMRO2) and oxygen extraction fraction (OEF), which represents the balance between cerebral blood flow (CBF) and CMRO2. Thirty-seven healthy adults aged ?50 underwent maximal cardiopulmonary exercise testing for VO2peak assessment. Neuroimaging included dual calibrated functional MRI (dc-fMRI) and quantitative susceptibility mapping (QSM). Higher VO2peak correlated positively with higher CBF across whole-brain gray matter but showed no relationship with CMRO2. Conversely, higher VO2peak negatively correlated with lower OEF from both dc-fMRI and QSM. These findings suggest that greater cardiorespiratory fitness enhances cerebral perfusion without changing resting metabolic rate in healthy older adults, resulting in a reduced oxygen extraction. These results are consistent with exercise yielding improved vascular-metabolic coupling, which would reduce the likelihood of transient hypoxic episodes. |
