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PubMed Publications| Keyword search (4,163 papers available) |  |
"Gagnon C" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 4 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 5 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 6 | Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol | Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau-Majeau F; Blanchette CA; Vitali P; Nigam A; | 40625372 PSYCHOLOGY |
| 7 | Psychometric Properties of a French Version of the Perceived Motor Competence in Childhood Questionnaire | Maïano C; Morin AJS; April J; Tietjens M; St-Jean C; Gagnon C; Dreiskämper D; Aimé A; | 33765895 PSYCHOLOGY |
| 8 | Validation of an Adapted Version of the Glasgow Anxiety Scale for People with Intellectual Disabilities (GAS-ID) | Maïano C; Morin AJS; Gagnon C; Olivier E; Tracey D; Craven RG; Bouchard S; | 35138559 PSYCHOLOGY |
| 9 | Validation of a Revised Version of the Center for Epidemiologic Depression Scale for Youth with Intellectual Disabilities (CESD-ID-R) | Olivier E; Lacombe C; Morin AJS; Houle SA; Gagnon C; Tracey D; Craven RG; Maïano C; | 34716523 PSYCHOLOGY |
| 10 | A psychometric validation of the motives for physical activity measure for youth with intellectual disabilities (MPAM-ID) | Maïano C; Morin AJS; Tracey D; Gagnon C; Smodis McCune V; Craven RG; | 34528859 PSYCHOLOGY |
| 11 | Development and Validation of a Multi-informant Measure of Social Behaviors for Youth with Intellectual Disabilities | Olivier E; Morin AJS; Tracey D; Verma N; Dubé C; Gagnon C; Craven RG; Maïano C; | 34255229 PSYCHOLOGY |
| 12 | Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults | Bherer L; Gagnon C; Langeard A; Lussier M; Desjardins-Crépeau L; Berryman N; Bosquet L; Vu TTM; Fraser S; Li KZH; Kramer AF; | 32803232 PERFORM |
| 13 | A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. | Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L | 29235076 PERFORM |
| Title: | Clinical Manifestations | ||||
| Authors: | Gagnon C, Montero-Odasso M, Zou G, Speechley MR, Almeida QJ, Liu-Ambrose T, Middleton LE, Camicioli R, Bray NW, Li K, Fraser S, Pieruccini-Faria F, Burhan AM, Berryman N, Lussier M, Son S, Shoemaker JK, Bherer L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41447475/ | ||||
| DOI: | 10.1002/alz70857_102937 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | |||||
| PMID: | 41447475 | Category: | Date Added: | 2025-12-25 | |
| Dept Affiliation: |
CONCORDIA
1 Montreal Heart Institute, Montreal, QC, Canada. 2 Schulich School of Medicine & Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 3 Parkwood Institute, London, ON, Canada. 4 Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. 5 University of Wester Ontario, London, ON, Canada. 6 Wilfrid Laurier University, Waterloo, ON, Canada. 7 Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 8 Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 9 University of British Columbia, Vancouver, BC, Canada. 10 Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. 11 Schlegel-UW Research Institute for Aging, Waterloo, ON, Canada. 12 University of Waterloo, Waterloo, ON, Canada. 13 University of Alberta, Edmonton, AB, Canada. 14 University of Western Ontario, London, ON, Canada. 15 Concordia University, Montreal, QC, Canada. 16 University of Ottawa, Ottawa, ON, Canada. 17 Gait and Brain Laboratory, Parkwood Institute, London, ON, Canada. 18 Gait & Brain Lab; Lawson Research Institute; Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 19 University of Toronto, Toronto, ON, Canada. 20 Parkwood Institute-Mental Health, Western University, London, ON, Canada. 21 Western University, London, ON, Canada. 22 Ontario Shores Centre for Mental Health Sciences, Whitby, ON, Canada. 23 Université du Québec à Montréal, Montréal, QC, Canada. 24 University of Montreal, Montreal, QC, Canada. 25 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada. 26 Université de Montréal, Montréal, QC, Canada. 27 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. 28 Montreal Heart Institute, Montréal, QC, Canada. |
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Description: |
Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to greater gains on the ADAS-Cog than an active control condition, and physical exercise alone. Yet not all participants showed the same cognitive gains. To date, little is known about the cognitive characteristics of responders vs non-responders to non-pharmacological interventions. Objective: To compare baseline cognitive profiles of responders and non-responders to physical exercise training alone or in combination with cognitive training. Methods: Of the 175 initially randomized individuals with MCI in the SYNERGIC trial, 143 completed the 6-month assessment. Regardless of randomization, participants were identified as responders if the change in ADAS-Cog-13 (T6-T0) was negative, indicating improved performances, and non-responders were determined if change was null or positive, indicating decreased performance. Composite z-scores were calculated from the baseline neuropsychological assessment: Global cognition (MoCA), Language (Boston Naming Test, Semantic Verbal fluency), Memory (MoCA delayed recall subscore), Processing Speed (TMT A, Stroop Naming, Stroop Reading), Working Memory (Digit span forward and backward), and Executive Functions (TMT B, Stroop Inhibition and Switching). Results: Responders (n = 91; 72yrs, 46% female, ADAS-Cog(T0): 15.81) and non-responders (n = 52; 74.2yrs, 54% female, ADAS-Cog(T0): 15.13) were comparable for sex, baseline ADAS-Cog; a trend was observed for older age in non-responders (p = .062). Overall, at baseline, responders had better global cognition (0.14±0.94 vs -0.23±1.07) and executive function performances than non-responders (0.12±0.77 vs-0.21±0.97), ps < .05, but were otherwise comparable. In the intervention arms, the proportion of responders differed significantly: Combined (75%), Physical alone (61%), Active control (44%), (p < .05). In the Combined group, responders had better global cognition (0.38±0.96 Vs -0.20±0.97) and working memory performances (0.25±0.96 Vs -0.28±0.47). In the Physical Alone group, responders and non-responders performed similarly. In the Active Control group, responders had better processing speed performances (0.22±0.31 vs -0.33±0.79) than non-responders. Conclusion: Responders and non-responders appear to have different baseline cognitive profiles. These results suggest that cognitive and physical training interventions should be tailored and individualized according to baseline cognitive condition. |
