Keyword search (4,163 papers available)

"Nat Commun" Category Publications:

Title Authors PubMed ID
1 Auditory information enhances post-sensory visual evidence during rapid multisensory decision-making. Franzen L; Delis I; De Sousa G; Kayser C; Philiastides MG; 33116148
CONCORDIA
2 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
3 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ 32620756
BIOLOGY
4 Evolving perspectives on the sources of the frequency-following response. Coffey EBJ, Nicol T, White-Schwoch T, Chandrasekaran B, Krizman J, Skoe E, Zatorre RJ, Kraus N 31695046
PSYCHOLOGY
5 Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA 31604953
BIOLOGY
6 Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, Sylvestre JP, Rosa-Neto P, Mathotaarachchi S, Gauthier S, Nasreddine ZS, Arbour JD, Rhéaume MA, Beaulieu S, Dirani M, Nguyen CTO, Bui BV, Williamson R, Crowston JG, van Wijngaarden P 31530809
PERFORM
7 Author Correction: Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31296848
CHEMBIOCHEM
8 Neural correlates of two different types of extinction learning in the amygdala central nucleus. Iordanova MD, Deroche ML, Esber GR, Schoenbaum G 27531638
CSBN
9 The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. McNally EK, Brett CL 30560896
BIOLOGY
10 A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host. Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segura M, Feldman MF 30792408
BIOLOGY
11 Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ 24513861
BIOLOGY
12 Giant electron-hole transport asymmetry in ultra-short quantum transistors. McRae AC, Tayari V, Porter JM, Champagne AR 28561024
PHYSICS
13 Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31068573
CHEMBIOCHEM

 

Title:Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.
Authors:Fossati EEkins ANarcross LZhu YFalgueyret JPBeaudoin GAFacchini PJMartin VJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/24513861?dopt=Abstract
DOI:10.1038/ncomms4283
Publication:Nature communications
Keywords:
PMID:24513861 Category:Nat Commun Date Added:2019-06-07
Dept Affiliation: BIOLOGY
1 1] Department of Biology, Concordia University, Montréal, Québec, Canada H4B 1R6 [2] Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec, Canada H4B 1R6 [3].
2 1] Department of Biology, Concordia University, Montréal, Québec, Canada H4B 1R6 [2] Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec, Canada H4B 1R6.
3 Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec, Canada H4B 1R6.
4 Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4.

Description:

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.

Nat Commun. 2014;5:3283

Authors: Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ

Abstract

Benzylisoquinoline alkaloids (BIAs) represent a large class of plant secondary metabolites, including pharmaceuticals such as morphine, codeine and their derivatives. Large-scale production of BIA-based pharmaceuticals is limited to extraction and derivatization of alkaloids that accumulate in planta. Synthesis of BIAs in microbial hosts could bypass such limitations and transform both industrial production of BIAs with recognized value and research into uncharacterized BIAs. Here we reconstitute a 10-gene plant pathway in Saccharomyces cerevisiae that allows for the production of dihydrosanguinarine and its oxidized derivative sanguinarine from (R,S)-norlaudanosoline. Synthesis of dihydrosanguinarine also yields the side-products N-methylscoulerine and N-methylcheilanthifoline, the latter of which has not been detected in plants. This work represents the longest reconstituted alkaloid pathway ever assembled in yeast and demonstrates the feasibility of the production of high-value alkaloids in microbial systems.

PMID: 24513861 [PubMed - indexed for MEDLINE]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University