Keyword search (4,163 papers available)

"Nat Commun" Category Publications:

Title Authors PubMed ID
1 Auditory information enhances post-sensory visual evidence during rapid multisensory decision-making. Franzen L; Delis I; De Sousa G; Kayser C; Philiastides MG; 33116148
CONCORDIA
2 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
3 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ 32620756
BIOLOGY
4 Evolving perspectives on the sources of the frequency-following response. Coffey EBJ, Nicol T, White-Schwoch T, Chandrasekaran B, Krizman J, Skoe E, Zatorre RJ, Kraus N 31695046
PSYCHOLOGY
5 Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA 31604953
BIOLOGY
6 Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, Sylvestre JP, Rosa-Neto P, Mathotaarachchi S, Gauthier S, Nasreddine ZS, Arbour JD, Rhéaume MA, Beaulieu S, Dirani M, Nguyen CTO, Bui BV, Williamson R, Crowston JG, van Wijngaarden P 31530809
PERFORM
7 Author Correction: Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31296848
CHEMBIOCHEM
8 Neural correlates of two different types of extinction learning in the amygdala central nucleus. Iordanova MD, Deroche ML, Esber GR, Schoenbaum G 27531638
CSBN
9 The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. McNally EK, Brett CL 30560896
BIOLOGY
10 A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host. Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segura M, Feldman MF 30792408
BIOLOGY
11 Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ 24513861
BIOLOGY
12 Giant electron-hole transport asymmetry in ultra-short quantum transistors. McRae AC, Tayari V, Porter JM, Champagne AR 28561024
PHYSICS
13 Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31068573
CHEMBIOCHEM

 

Title:Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.
Authors:Riglar DTRichmond DLPotvin-Trottier LVerdegaal AANaydich ADBakshi SLeoncini ELyon LGPaulsson JSilver PA
Link:https://www.ncbi.nlm.nih.gov/pubmed/31604953?dopt=Abstract
DOI:10.1038/s41467-019-12638-z
Publication:Nature communications
Keywords:
PMID:31604953 Category:Nat Commun Date Added:2019-10-13
Dept Affiliation: BIOLOGY
1 Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
2 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
3 Department of Infectious Disease, Imperial College London, London, UK.
4 Image and Data Analysis Core, Harvard Medical School, Boston, MA, USA.
5 Biology Department, Concordia University, Montreal, QC, Canada.
6 Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA.
7 Department of Engineering, Cambridge University, Cambridge, UK.
8 Department of Systems Biology, Harvard Medical School, Boston, MA, USA. Pamela_Silver@hms.harvard.edu.
9 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. Pamela_Silver@hms.harvard.edu.

Description:

Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.

Nat Commun. 2019 Oct 11;10(1):4665

Authors: Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA

Abstract

Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the robustness and precision necessary for applications in complex in vivo environments, such as the mammalian gut. Here, we demonstrate the implementation of a synthetic oscillator capable of keeping robust time in the mouse gut over periods of days. The oscillations provide a marker of bacterial growth at a single-cell level enabling quantification of bacterial dynamics in response to inflammation and underlying variations in the gut microbiota. Our work directly detects increased bacterial growth heterogeneity during disease and differences between spatial niches in the gut, demonstrating the deployment of a precise engineered genetic oscillator in real-life settings.

PMID: 31604953 [PubMed - in process]





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