Keyword search (4,163 papers available)

"Shizgal P" Authored Publications:

Title Authors PubMed ID
1 Discriminative properties of rewarding electrical brain stimulation Pacheco-Gomez BL; Zepeda-Ruiz WA; Velazquez-Lopez D; Shizgal P; Velazquez-Martinez DN; 40015584
CSBN
2 Does phasic dopamine release cause policy updates? Carter F; Cossette MP; Trujillo-Pisanty I; Pallikaras V; Breton YA; Conover K; Caplan J; Solis P; Voisard J; Yaksich A; Shizgal P; 38039083
PSYCHOLOGY
3 Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression Pallikaras V; Shizgal P; 36009115
PSYCHOLOGY
4 The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle Pallikaras V; Shizgal P; 35431828
PSYCHOLOGY
5 The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch's law Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P; 34864162
PSYCHOLOGY
6 Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P 32502210
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7 The priming effect of food persists following blockade of dopamine receptors. Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG 31350860
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8 Learning to use past evidence in a sophisticated world model. Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P 31233559
CSBN
9 Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation. Hernandez G, Cossette MP, Shizgal P, Rompré PP 27616984
PSYCHOLOGY
10 Valuation of opportunity costs by rats working for rewarding electrical brain stimulation. Solomon RB, Conover K, Shizgal P 28841663
PSYCHOLOGY
11 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN
12 Some work and some play: microscopic and macroscopic approaches to labor and leisure. Niyogi RK, Shizgal P, Dayan P 25474151
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13 Robust optical fiber patch-cords for in vivo optogenetic experiments in rats. Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P 26150997
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14 The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses. Cossette MP, Conover K, Shizgal P 26477378
CSBN
15 The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB 26696851
CSBN

 

Title:The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
Authors:Scardochio T,  Trujillo-Pisanty I,  Conover K,  Shizgal P,  Clarke PB
Link:https://www.ncbi.nlm.nih.gov/pubmed/26696851?dopt=Abstract
Publication:
Keywords:
PMID:26696851 Category:Front Behav Neurosci Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Pharmacology and Therapeutics, Neuropsychopharmacology, McGill University Montreal, QC, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University Montreal, QC, Canada.
3 Department of Pharmacology and Therapeutics, Neuropsychopharmacology, McGill University Montreal, QC, Canada ; Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University Montreal, QC, Canada.

Description:

The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.

Front Behav Neurosci. 2015;9:331

Authors: Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB

Abstract

RATIONALE: Adult rats emit ultrasonic vocalizations (USVs) at around 50-kHz; these commonly occur in contexts that putatively engender positive affect. While several reports indicate that dopaminergic (DAergic) transmission plays a role in the emission of 50-kHz calls, the pharmacological evidence is mixed. Different modes of dopamine (DA) release (i.e., tonic and phasic) could potentially explain this discrepancy.

OBJECTIVE: To investigate the potential role of phasic DA release in 50-kHz call emission.

METHODS: In Experiment 1, USVs were recorded in adult male rats following unexpected electrical stimulation of the medial forebrain bundle (MFB). In parallel, phasic DA release in the nucleus accumbens (NAcc) was recorded using fast-scan cyclic voltammetry. In Experiment 2, USVs were recorded following response-contingent or non-contingent optogenetic stimulation of midbrain DAergic neurons. Four 20-s schedules of optogenetic stimulation were used: fixed-interval, fixed-time, variable-interval, and variable-time.

RESULTS: Brief electrical stimulation of the MFB increased both 50-kHz call rate and phasic DA release in the NAcc. During optogenetic stimulation sessions, rats initially called at a high rate comparable to that observed following reinforcers such as psychostimulants. Although optogenetic stimulation maintained reinforced responding throughout the 2-h session, the call rate declined to near zero within the first 30 min. The trill call subtype predominated following both electrical and optical stimulation.

CONCLUSION: The occurrence of electrically-evoked 50-kHz calls, time-locked to phasic DA (Experiment 1), provides correlational evidence supporting a role for phasic DA in USV production. However, in Experiment 2, the temporal dissociation between calling and optogenetic stimulation of midbrain DAergic neurons suggests that phasic mesolimbic DA release is not sufficient to produce 50-kHz calls. The emission of the trill subtype of 50-kHz calls potentially provides a marker distinguishing positive affect from positive reinforcement.

PMID: 26696851 [PubMed]




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