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PubMed Publications| Keyword search (4,163 papers available) |  |
"Lussier M" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 2 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 3 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 4 | At-home computerized executive-function training to improve cognition and mobility in normal-hearing adults and older hearing aid users: a multi-centre, single-blinded randomized controlled trial | Downey R; Gagné N; Mohanathas N; Campos JL; Pichora-Fuller KM; Bherer L; Lussier M; Phillips NA; Wittich W; St-Onge N; Gagné JP; Li K; | 37864139 PERFORM |
| 5 | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; | 37471089 PERFORM |
| 6 | Multiple routes to help you roam: A comparison of training interventions to improve cognitive-motor dual-tasking in healthy older adults | Downey R; Bherer L; Pothier K; Vrinceanu T; Intzandt B; Berryman N; Lussier M; Vincent T; Karelis AD; Nigam A; Vu TTM; Bosquet L; Li KZH; | 36408116 PERFORM |
| 7 | A comparison of the effect of physical activity and cognitive training on dual-task performance in older adults | Vrinceanu T; Blanchette CA; Intzandt B; Lussier M; Pothier K; Vu TTM; Nigam A; Bosquet L; Karelis AD; Li KZH; Berryman N; Bherer L; | 34865009 PERFORM |
| 8 | Assessment of the Relationship Between Executive Function and Cardiorespiratory Fitness in Healthy Older Adults | Predovan D; Berryman N; Lussier M; Comte F; Vu TTM; Villalpando JM; Bherer L; | 34803824 PERFORM |
| 9 | A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults | Pothier K; Vrinceanu T; Intzandt B; Bosquet L; Karelis AD; Lussier M; Vu TTM; Nigam A; Li KZH; Berryman N; Bherer L; | 33774144 PERFORM |
| 10 | Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults | Bherer L; Gagnon C; Langeard A; Lussier M; Desjardins-Crépeau L; Berryman N; Bosquet L; Vu TTM; Fraser S; Li KZH; Kramer AF; | 32803232 PERFORM |
| 11 | Ageism and COVID-19: What does our society's response say about us? | Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beaulieu M, Bergeron CD, Boudjemadi V, Desmette D, Donizzetti AR, Éthier S, Garon S, Gillis M, Levasseur M, Lortie-Lussier M, Marier P, Robitaille A, Sawchuk K, Lafontaine C, Tougas F | 32377666 PSYCHOLOGY |
| 12 | Effects of Dance/Movement Training vs. Aerobic Exercise Training on cognition, physical fitness and quality of life in older adults: A randomized controlled trial. | Esmail A, Vrinceanu T, Lussier M, Predovan D, Berryman N, Houle J, Karelis A, Grenier S, Minh Vu TT, Villalpando JM, Bherer L | 31987547 PERFORM |
| 13 | SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. | Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L | 29661156 PERFORM |
| 14 | Switching Ability Mediates the Age-Related Difference in Timed Up and Go Performance. | Langeard A, Houdeib R, Saillant K, Kaushal N, Lussier M, Bherer L | 30909238 PSYCHOLOGY |
| 15 | Limited Benefits of Heterogeneous Dual-Task Training on Transfer Effects in Older Adults. | Lussier M, Brouillard P, Bherer L | 26603017 PERFORM |
| 16 | Specific transfer effects following variable priority dual-task training in older adults. | Lussier M, Bugaiska A, Bherer L | 27372514 PERFORM |
| 17 | A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. | Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L | 29235076 PERFORM |
| Title: | Clinical Manifestations | ||||
| Authors: | Gagnon C, Montero-Odasso M, Zou G, Speechley MR, Almeida QJ, Liu-Ambrose T, Middleton LE, Camicioli R, Bray NW, Li K, Fraser S, Pieruccini-Faria F, Burhan AM, Berryman N, Lussier M, Son S, Shoemaker JK, Bherer L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41447475/ | ||||
| DOI: | 10.1002/alz70857_102937 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | |||||
| PMID: | 41447475 | Category: | Date Added: | 2025-12-25 | |
| Dept Affiliation: |
CONCORDIA
1 Montreal Heart Institute, Montreal, QC, Canada. 2 Schulich School of Medicine & Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 3 Parkwood Institute, London, ON, Canada. 4 Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. 5 University of Wester Ontario, London, ON, Canada. 6 Wilfrid Laurier University, Waterloo, ON, Canada. 7 Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 8 Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 9 University of British Columbia, Vancouver, BC, Canada. 10 Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. 11 Schlegel-UW Research Institute for Aging, Waterloo, ON, Canada. 12 University of Waterloo, Waterloo, ON, Canada. 13 University of Alberta, Edmonton, AB, Canada. 14 University of Western Ontario, London, ON, Canada. 15 Concordia University, Montreal, QC, Canada. 16 University of Ottawa, Ottawa, ON, Canada. 17 Gait and Brain Laboratory, Parkwood Institute, London, ON, Canada. 18 Gait & Brain Lab; Lawson Research Institute; Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 19 University of Toronto, Toronto, ON, Canada. 20 Parkwood Institute-Mental Health, Western University, London, ON, Canada. 21 Western University, London, ON, Canada. 22 Ontario Shores Centre for Mental Health Sciences, Whitby, ON, Canada. 23 Université du Québec à Montréal, Montréal, QC, Canada. 24 University of Montreal, Montreal, QC, Canada. 25 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada. 26 Université de Montréal, Montréal, QC, Canada. 27 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. 28 Montreal Heart Institute, Montréal, QC, Canada. |
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Description: |
Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to greater gains on the ADAS-Cog than an active control condition, and physical exercise alone. Yet not all participants showed the same cognitive gains. To date, little is known about the cognitive characteristics of responders vs non-responders to non-pharmacological interventions. Objective: To compare baseline cognitive profiles of responders and non-responders to physical exercise training alone or in combination with cognitive training. Methods: Of the 175 initially randomized individuals with MCI in the SYNERGIC trial, 143 completed the 6-month assessment. Regardless of randomization, participants were identified as responders if the change in ADAS-Cog-13 (T6-T0) was negative, indicating improved performances, and non-responders were determined if change was null or positive, indicating decreased performance. Composite z-scores were calculated from the baseline neuropsychological assessment: Global cognition (MoCA), Language (Boston Naming Test, Semantic Verbal fluency), Memory (MoCA delayed recall subscore), Processing Speed (TMT A, Stroop Naming, Stroop Reading), Working Memory (Digit span forward and backward), and Executive Functions (TMT B, Stroop Inhibition and Switching). Results: Responders (n = 91; 72yrs, 46% female, ADAS-Cog(T0): 15.81) and non-responders (n = 52; 74.2yrs, 54% female, ADAS-Cog(T0): 15.13) were comparable for sex, baseline ADAS-Cog; a trend was observed for older age in non-responders (p = .062). Overall, at baseline, responders had better global cognition (0.14±0.94 vs -0.23±1.07) and executive function performances than non-responders (0.12±0.77 vs-0.21±0.97), ps < .05, but were otherwise comparable. In the intervention arms, the proportion of responders differed significantly: Combined (75%), Physical alone (61%), Active control (44%), (p < .05). In the Combined group, responders had better global cognition (0.38±0.96 Vs -0.20±0.97) and working memory performances (0.25±0.96 Vs -0.28±0.47). In the Physical Alone group, responders and non-responders performed similarly. In the Active Control group, responders had better processing speed performances (0.22±0.31 vs -0.33±0.79) than non-responders. Conclusion: Responders and non-responders appear to have different baseline cognitive profiles. These results suggest that cognitive and physical training interventions should be tailored and individualized according to baseline cognitive condition. |
