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PubMed Publications| Keyword search (4,163 papers available) |  |
"Li J" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Development of an evaporation-driven sampling system for the in situ long-term monitoring of heavy metals in surface water | Li X; Ma H; Shi S; Tian X; Nie L; Han X; Sun J; Chen Z; Li J; Chen K; | 41886856 ENCS |
| 2 | Clinical Manifestations | Jobin B; Frasnelli J; Phillips NA; Boller B; | 41443638 CONCORDIA |
| 3 | Intraspecific complexity in mercury contamination of two harvested fishes revealed by genetics: Food security and conservation implications | Gibelli J; Michaelides S; Won H; Chamlian B; Bampfylde C; Maclean B; Giroux P; Gray QZ; Voyageur M; Jeon HB; Bouchard R; Fraser DJ; | 41380599 BIOLOGY |
| 4 | Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 41056215 HKAP |
| 5 | The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort | Jobin B; Phillips NA; Frasnelli J; Boller B; | 40944318 PSYCHOLOGY |
| 6 | Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect" | Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W; | 40051055 ENCS |
| 7 | Genomics-Enabled Mixed-Stock Analysis Uncovers Intraspecific Migratory Complexity and Detects Unsampled Populations in a Harvested Fish | Gibelli J; Won H; Michaelides S; Jeon HB; Fraser DJ; | 39995301 BIOLOGY |
| 8 | Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era | Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ; | 39730611 BIOLOGY |
| 9 | Sustainable and energy-saving hydrogen production via binder-free and in situ electrodeposited Ni-Mn-S nanowires on Ni-Cu 3-D substrates | Barati Darband G; Iravani D; Zhang M; Maleki M; Huang S; Khoshfetrat SM; Andaveh R; Li J; | 39655509 ENCS |
| 10 | Integrative approach to mitigate chromium toxicity in soil and enhance antioxidant activities in rice (Oryza sativa L.) using magnesium-iron nanocomposite and Staphylococcus aureus strains | Ali MA; Sardar MF; Dar AA; Niaz M; Ali J; Wang Q; Zheng Y; Luo Y; Albasher G; Li F; | 39190219 ENCS |
| 11 | A multidimensional investigation of sleep and biopsychosocial profiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 38659875 HKAP |
| 12 | A multidimensional investigation of sleep and biopsychosocialprofiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Thomas Yeo BT; | 38559143 HKAP |
| 13 | Alternative Oxidase: From Molecule and Function to Future Inhibitors | Li J; Yang S; Wu Y; Wang R; Liu Y; Liu J; Ye Z; Tang R; Whiteway M; Lv Q; Yan L; | 38524433 BIOLOGY |
| 14 | Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption | Yang JG; Sun B; Wang Z; Li X; Gao JH; Qian JJ; Li J; Wei WJ; Zhang P; Wang W; | 37957146 ENCS |
| 15 | Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast | Sultana S; Abdullah M; Li J; Hochstrasser M; Kachroo AH; | 37364278 BIOLOGY |
| 16 | The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum | Li J; Chroumpi T; Garrigues S; Kun RS; Meng J; Salazar-Cerezo S; Aguilar-Pontes MV; Zhang Y; Tejomurthula S; Lipzen A; Ng V; Clendinen CS; Tolic N; Grigoriev IV; Tsang A; Mäkelä MR; Snel B; Peng M; de Vries RP; | 36547648 BIOLOGY |
| 17 | Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate | Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J; | 35886903 BIOLOGY |
| 18 | Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in groundwater: current understandings and challenges to overcome | Zhao Z; Li J; Zhang X; Wang L; Wang J; Lin T; | 35593984 CHEMBIOCHEM |
| 19 | The Effect of Stimulus Duration on the Nostril Localization of Eucalyptol. | Frasnelli J, Gingras-Lessard F, Robert J, Steffener J | 28334125 PERFORM |
| 20 | The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. | Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R | 31522764 CSBN |
| 21 | Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure. | Commowick O, Istace A, Kain M, Laurent B, Leray F, Simon M, Pop SC, Girard P, Améli R, Ferré JC, Kerbrat A, Tourdias T, Cervenansky F, Glatard T, Beaumont J, Doyle S, Forbes F, Knight J, Khademi A, Mahbod A, Wang C, McKinley R, Wagner F, Muschelli J, Sweeney E, Roura E, Lladó X, Santos MM, Santos WP, Silva-Filho AG, Tomas-Fernandez X, Urien H, Bloch I, Valverde S, Cabezas M, Vera-Olmos FJ, Malpica N, Guttmann C, Vukusic S, Edan G, Dojat M, Styner M, Warfield SK, Cotton F, Barillot C | 30209345 ENCS |
| Title: | Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect" | ||||
| Authors: | Sun B, Yang JG, Wang Z, Wang Z, Feng W, Li X, Liu SN, Li J, Zhu YQ, Zhang P, Wang W | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40051055/ | ||||
| DOI: | 10.1002/ctm2.70266 | ||||
| Publication: | Clinical and translational medicine | ||||
| Keywords: | exon junction complexes; m6A distribution characteristics; osteoclast; osteoporosis; shield effect; | ||||
| PMID: | 40051055 | Category: | Date Added: | 2025-03-07 | |
| Dept Affiliation: |
ENCS
1 Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China. 2 Department of Stomatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, China. 4 Concordia Institute for Information Systems Engineering, Concordia University, Montreal, QC, Canada. 5 Department of Endodontics, Central Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Shandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue Regeneration, Jinan, Shandong, People's Republic of China. 6 Department of Oral Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital |
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Description: |
Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking. Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase reporter assays and CRISPR/Cas9 conditional knockout mice were used to elucidate the distribution characteristics of NFATc1 m6A. Results: METTL14 controls osteoclast-mediated bone resorption by means of the methylation (4249 A) of the NFATc1 gene during osteoclast differentiation. Exon junction complexes (EJCs) selectively protect the m6A methylation sites of the NFATc1 gene. When the methylation sites are located within short exon fragments (50-200 nt), EJCs prevent their hypermethylation and degradation through the "shield effect"; when the methylation sites are located in the 3' UTR region or long exon fragments (greater than 300 nt), the "shield effect" disappears. Downstream, YTHDF2 induced the degradation of hypermethylation NFATc1 transcripts without site restriction. Conclusions: EJCs act as "shields" to regulate the m6A region selectivity of the NFATc1 gene, thereby determining the characteristics of m6A distribution in the gene. Importantly, EJCs can raise the level of m6A methylation of NFATc1 and degrade its mRNA, thereby inhibiting osteoclast differentiation and preserving bone mass. These results will be helpful for identifying potential molecular targets for osteoporosis treatment. Key points: METTL14 controls osteoclast-mediated bone resorption by means of the methylation (4249 A) of the NFATc1 gene during osteoclast differentiation. Exon junction complexes (EJCs) protect the remaining methylation sites of the NFATc1 gene (located in the inner exon fragment of 50-200 nt) from hypermethylation and degradation. The "shield effect" disappears when the exon fragment is extended to 300 nt. Downstream, YTHDF2 induced the degradation of hypermethylation NFATc1 transcripts without site restriction. |
