Keyword search (4,163 papers available)

"Dumeaux V" Authored Publications:

Title Authors PubMed ID
1 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; 37888959
BIOLOGY
2 A metagenomic-based study of two sites from the Barbadian reef system Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT; 37009568
BIOLOGY
3 A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT; 35972285
BIOLOGY
4 The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans Omran RP; Ramírez-Zavala B; Aji Tebung W; Yao S; Feng J; Law C; Dumeaux V; Morschhäuser J; Whiteway M; 34849863
PERFORM
5 ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance Lismer A; Lambrot R; Lafleur C; Dumeaux V; Kimmins S; 34159325
PERFORM
6 Signal-mediated localization of Candida albicans pheromone response pathway components Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M; 33793759
PERFORM
7 Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S 33596408
PERFORM
8 Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance Lismer A; Siklenka K; Lafleur C; Dumeaux V; Kimmins S; 33068438
PERFORM
9 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM
10 Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts. Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ 32366868
PERFORM
11 The time-varying effect of radiotherapy after breast-conserving surgery for DCIS. Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L 31368035
PERFORM
12 Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1. Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M 31235750
PERFORM
13 Interactions between the tumor and the blood systemic response of breast cancer patients. Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M 28957325
BIOLOGY
14 Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response. Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M 30530734
PERFORM
15 Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S 30190545
PERFORM

 

Title:Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.
Authors:Lismer ADumeaux VLafleur CLambrot RBrind'Amour JLorincz MCKimmins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/33596408
DOI:10.1016/j.devcel.2021.01.014
Publication:Developmental cell
Keywords:H3K4me3chromatindietepigenetic inheritancefolate deficiencypre-implantation embryosperm
PMID:33596408 Category:Dev Cell Date Added:2021-02-18
Dept Affiliation: PERFORM
1 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada.
2 PERFORM Center, Concordia University, Montreal, QC H4B 1R6, Canada.
3 Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada.
4 Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
5 Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC H9X 3V9, Canada. Electronic address: sarah.kimmins@mcgill.ca.

Description:

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Dev Cell. 2021 Feb 15; :

Authors: Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

Abstract

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and development. Here, we demonstrate that a folate-deficient (FD) diet alters histone H3 lysine 4 trimethylation (H3K4me3) in sperm at developmental genes and putative enhancers. A subset of H3K4me3 alterations in sperm are retained in the pre-implantation embryo and associated with deregulated embryonic gene expression. Using a genetic mouse model in which sires have pre-existing altered H3K4me2/3 in sperm, we show that a FD diet exacerbates alterations in sperm H3K4me3 and embryonic gene expression, leading to an increase in developmental defect severity. These findings imply that paternal H3K4me3 is transmitted to the embryo and influences gene expression and development. It further suggests that epigenetic errors can accumulate in sperm to worsen offspring developmental outcomes.

PMID: 33596408 [PubMed - as supplied by publisher]





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