Keyword search (4,164 papers available)

"Dumeaux V" Authored Publications:

Title Authors PubMed ID
1 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; 37888959
BIOLOGY
2 A metagenomic-based study of two sites from the Barbadian reef system Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT; 37009568
BIOLOGY
3 A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT; 35972285
BIOLOGY
4 The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans Omran RP; Ramírez-Zavala B; Aji Tebung W; Yao S; Feng J; Law C; Dumeaux V; Morschhäuser J; Whiteway M; 34849863
PERFORM
5 ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance Lismer A; Lambrot R; Lafleur C; Dumeaux V; Kimmins S; 34159325
PERFORM
6 Signal-mediated localization of Candida albicans pheromone response pathway components Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M; 33793759
PERFORM
7 Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S 33596408
PERFORM
8 Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance Lismer A; Siklenka K; Lafleur C; Dumeaux V; Kimmins S; 33068438
PERFORM
9 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM
10 Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts. Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ 32366868
PERFORM
11 The time-varying effect of radiotherapy after breast-conserving surgery for DCIS. Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L 31368035
PERFORM
12 Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1. Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M 31235750
PERFORM
13 Interactions between the tumor and the blood systemic response of breast cancer patients. Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M 28957325
BIOLOGY
14 Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response. Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M 30530734
PERFORM
15 Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S 30190545
PERFORM

 

Title:The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.
Authors:Rakovitch ESutradhar RHallett MThompson AMGu SDumeaux VWhelan TJPaszat L
Link:https://www.ncbi.nlm.nih.gov/pubmed/31368035?dopt=Abstract
DOI:10.1007/s10549-019-05377-8
Publication:Breast cancer research and treatment
Keywords:DCISDuctal carcinoma in situHazardsLocal recurrenceRadiation
PMID:31368035 Category:Breast Cancer Res Treat Date Added:2019-08-07
Dept Affiliation: PERFORM
1 Department of Radiation Oncology, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
2 ICES, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
3 Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. eileen.rakovitch@sunnybrook.ca.
4 LC Campbell Chair in Breast Cancer Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. eileen.rakovitch@sunnybrook.ca.
5 ICES, Toronto, ON, Canada.
6 Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
7 Department of Biology, Concordia University, Montreal, QC, Canada.
8 School of Computer Science, McGill University, Montreal, QC, Canada.
9 Dan L Duncan Comprehensive Cancer Center, Division of Surgical, Baylor College of Medicine, Houston, TX, USA.
10 PERFORM Centre, Concordia University, Montréal, QC, Canada.
11 Department of Oncology, McMaster University, Hamilton, ON, Canada.
12 Department of Radiation Oncology, Toronto, ON, Canada.

Description:

The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.

Breast Cancer Res Treat. 2019 Jul 31;:

Authors: Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L

Abstract

BACKGROUND: A better understanding underlying radiation (RT) response after breast-conserving surgery (BCS) is needed to mitigate over-treatment of DCIS. The hazard ratio (HR) measures the effect of RT but assumes the effect is constant over time. We examined the hazard function adjusted for adherence to surveillance mammography to examine variations in LR risk and the effect of RT over time.

METHODS: Crude hazard estimates for the development of LR in a population cohort of DCIS treated by BCS?±?RT were computed. Multivariable extended Cox models and hazard plots were used to examine the association between receipt of RT and risk of each outcome adjusted for baseline covariates and adherence to mammography.

RESULTS: Population cohort includes 3262 women treated by BCS; 1635 received RT. Median follow-up was 13 years. LR developed in 364 women treated by BCS alone and 274 treated with RT. LR risk peaked at 2 years, declined until year 7, and then remained steady. The peak hazard of LR was associated with adverse features of DCIS. Early LR risk was attenuated in patients treated with RT but late annual risks of LR and invasive LR were similar among the two treatment groups. On multivariate analysis, RT was associated with a reduction in early LR risk (HR?=?0.52, 95% CI 0.43-0.63, p?<?0.0001) but did not reduce the risk of late LR (HR?=?0.89, 95% CI: 0.67, 1.19, p?=?0.44) (interaction, p?=?0.002).

CONCLUSIONS: The effect of RT is not uniform over time and greatest in the first 7 years after BCS for DCIS, which can guide future research to understand mechanisms underlying RT response and optimize future management of DCIS.

PMID: 31368035 [PubMed - as supplied by publisher]





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