PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds	Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;	37888959 BIOLOGY
2	A metagenomic-based study of two sites from the Barbadian reef system	Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT;	37009568 BIOLOGY
3	A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies	Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;	35972285 BIOLOGY
4	The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans	Omran RP; Ramírez-Zavala B; Aji Tebung W; Yao S; Feng J; Law C; Dumeaux V; Morschhäuser J; Whiteway M;	34849863 PERFORM
5	ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance	Lismer A; Lambrot R; Lafleur C; Dumeaux V; Kimmins S;	34159325 PERFORM
6	Signal-mediated localization of Candida albicans pheromone response pathway components	Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M;	33793759 PERFORM
7	Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.	Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S	33596408 PERFORM
8	Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance	Lismer A; Siklenka K; Lafleur C; Dumeaux V; Kimmins S;	33068438 PERFORM
9	Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.	Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG	32610139 PERFORM
10	Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.	Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ	32366868 PERFORM
11	The time-varying effect of radiotherapy after breast-conserving surgery for DCIS.	Rakovitch E, Sutradhar R, Hallett M, Thompson AM, Gu S, Dumeaux V, Whelan TJ, Paszat L	31368035 PERFORM
12	Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.	Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M	31235750 PERFORM
13	Interactions between the tumor and the blood systemic response of breast cancer patients.	Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M	28957325 BIOLOGY
14	Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.	Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M	30530734 PERFORM
15	Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.	Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S	30190545 PERFORM

Title:	Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Authors:	Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32610139?dopt=Abstract
DOI:	10.1016/j.celrep.2020.107838
Publication:	Cell reports
Keywords:	ATRX; H3K27me3; chromatin; hippocampus; intellectual disability; long-term spatial memory; miR-137; presynaptic vesicles; sex differences; synapse;
PMID:	32610139	Category:	Cell Rep	Date Added:	2020-07-02
Dept Affiliation:	PERFORM 1 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada. 2 Department of Paediatrics, Western University, London, ON, Canada; PERFORM Centre, Concordia University, Montreal, QC, Canada. 3 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada. 4 Children's Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada. 5 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada. 6 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada. 7 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK. 8 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK. 9 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: nberube@uwo.ca.

Description:

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Cell Rep. 2020 Jun 30;31(13):107838

Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Abstract

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deletion of neuronal Atrx in mice leads to distinct hippocampal structural defects, fewer presynaptic vesicles, and an enlarged postsynaptic area at CA1 apical dendrite-axon junctions. We identify male-specific impairments in long-term contextual memory and in synaptic gene expression, linked to altered miR-137 levels. We show that ATRX directly binds to the miR-137 locus and that the enrichment of the suppressive histone mark H3K27me3 is significantly reduced upon the loss of ATRX. We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction.

PMID: 32610139 [PubMed - as supplied by publisher]

BookR: School of Health Core Facilities Booking

"Dumeaux V" Authored Publications:

Search Publications

No results