PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat	Germé K; Persad D; Petit-Robinson J; Amir S; Pfaus JG;	40232387 PSYCHOLOGY
2	Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats	Meyer C; Schoettner K; Amir S;	39624490 PSYCHOLOGY
3	The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats	Meyer C; Schoettner K; Amir S;	36620855 CSBN
4	Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2	Schoettner K; Alonso M; Button M; Goldfarb C; Herrera J; Quteishat N; Meyer C; Bergdahl A; Amir S;	35755440 HKAP
5	Thermoregulatory significance of immobility in the forced swim test	Nadeau BG; Marchant EG; Amir S; Mistlberger RE;	35065081 PSYCHOLOGY
6	Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner	de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S;	34702951 PSYCHOLOGY
7	In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders	Ferraro S; de Zavalia N; Belforte N; Amir S;	34650409 CSBN
8	The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.	Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R	31522764 CSBN
9	Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats.	Gavrila AM, Hood S, Robinson B, Amir S	28594962 CSBN
10	Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders.	Pantazopoulos H, Gamble K, Stork O, Amir S	29887881 PSYCHOLOGY
11	Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.	Frederick A, Goldsmith J, de Zavalia N, Amir S	28423013 BIOLOGY
12	Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day.	Harbour VL, Weigl Y, Robinson B, Amir S	24124556 PSYCHOLOGY
13	Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat.	Harbour VL, Weigl Y, Robinson B, Amir S	25068868 PSYCHOLOGY
14	Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.	Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R	25309348 BIOLOGY
15	Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability.	Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S	25338089 CSBN
16	Light-regulated translational control of circadian behavior by eIF4E phosphorylation.	Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N	25915475 CSBN
17	Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.	Al-Safadi S, Branchaud M, Rutherford S, Amir S	26075608 CSBN
18	Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again.	Verwey M, Al-Safadi S, Amir S	26195175 PSYCHOLOGY
19	From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness.	Verwey M, Amir S	27275497 CSBN
20	Exploring the role of locomotor sensitization in the circadian food entrainment pathway.	Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S	28301599 PSYCHOLOGY
21	Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.	Anyan J, Verwey M, Amir S	28763478 PSYCHOLOGY
22	Too Depressed to Swim or Too Afraid to Stop? A Reinterpretation of the Forced Swim Test as a Measure of Anxiety-Like Behavior.	Anyan J, Amir S	29210364 PSYCHOLOGY
23	mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction	Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R;	29555746 CSBN

Title:	The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.
Authors:	Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R
Link:	https://www.ncbi.nlm.nih.gov/pubmed/31522764?dopt=Abstract
DOI:	10.1016/j.neuron.2019.08.007
Publication:	Neuron
Keywords:	ATF4; GCN2; Per2; SCN; circadian clock; eIF2; mouse;
PMID:	31522764	Category:	Neuron	Date Added:	2019-09-17
Dept Affiliation:	CSBN 1 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA. 2 Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. 3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada. 5 Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada. 6 Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA. 7 Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92307, USA. 8 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: shimon.amir@concordia.ca. 9 Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address: nahum.sonenberg@mcgill.ca. 10 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA; Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: rcao@umn.edu.

Description:

The eIF2a Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Neuron. 2019 Aug 26;:

Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Abstract

The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons. Central to this process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2a). Here, we report a critical role for ISR in regulating the mammalian circadian clock. The eIF2a kinase GCN2 rhythmically phosphorylates eIF2a in the suprachiasmatic circadian clock. Increased eIF2a phosphorylation shortens the circadian period in both fibroblasts and mice, whereas reduced eIF2a phosphorylation lengthens the circadian period and impairs circadian rhythmicity in animals. Mechanistically, phosphorylation of eIF2a promotes mRNA translation of Atf4. ATF4 binding motifs are identified in multiple clock genes, including Per2, Per3, Cry1, Cry2, and Clock. ATF4 binds to the TTGCAGCA motif in the Per2 promoter and activates its transcription. Together, these results demonstrate a significant role for ISR in circadian physiology and provide a potential link between dysregulated ISR and circadian dysfunction in brain diseases.

PMID: 31522764 [PubMed - as supplied by publisher]

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