1 Lady Davis Institute for Medical Research, Montréal, Québec, Canada.
2 Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.
3 Rotman Research Institute, Baycrest Academy for Research & Education, Toronto, Ontario, Canada.
4 Affiliate Member, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
5 Department of Psychology, Concordia University, Montréal, Québec, Canada.
6 Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
7 Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
8 Division of Geriatric Medicine, Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
9 Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
10 The Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada.
11 McGill Centre for Integrative Neuroscience, Montréal, Québec, Canada.
12 Centre de recherche IUGM, Institut universitaire de gériatrie de Montréal, Montréal, Québec, Canada.
13 Département de psychologie, Université de Montréal, Montréal, Québec, Canada.
14 Department of Medicine (Geriatrics) and Oncology, McGill University, Montréal, Québec, Canada.
15 Department of Family Medicine, McGill University, Montréal, Québec, Canada.
16 Lawson Health Research Institute, London, Ontario, Canada.
17 KITE-Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
18 Département de médecine, Université de Montréal, Montréal, Québec, Canada.
19 Institut de Cardiologie de Montréal-Montreal Heart Institute, Montréal, Québec, Canada.
20 Sunnybrook Research Institute, Toronto, Ontario, Canada.
21 Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada.
22 Schulich School of Medicine & Dentistry, Department of Medicine and Division of Geriatric Medicine, University of Western Ontario, London, Ontario, Canada.
23 Schulich School of Medicine & Dentistry, Department of Medicine and Division of Geriatric Medicine, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
24 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Neuroscience and Mental Health Institute, Edmonton, Alberta, Canada.
25 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
26 Neuroscience and Mental Health Institute, Edmonton, Alberta, Canada.
27 Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
28 Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
29 Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
30 Rotman Research Institute, Baycrest Hospital, Toronto, Ontario, Canada.
31 Department of Family Medicine & Indigenous, Local and Global Health Office, University of Calgary, Calgary, Alberta, Canada.
32 Department of Neurology and Neurosurgery, McGill University, Montréal, Qikb1uébec, Canada.
33 Department of Pharmacology & Therapeutics, McGill Univers

The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized "centrally-organized" approach to dementia research can catalyze important progress nationally and yield significant and measurable results.