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Predicting the way forward for the Global Biodiversity Framework

Author(s): Zurell D; Bocedi G; Velazco SJE; Gonzalez A; Purvis A; Wintle B; Merow C; Lundquist C; Guillera-Arroita G; Settele J; Serra-Diaz JM; Cabral JS; Travis JMJ; Schifferle K; Buckley L; Briscoe NJ; Isaac NJB; Peres-Neto PR; Keuth R; Gascoigne SJL; Ferrier S; Urban MC;

Article GUID: 41060752


Sequential antibiotic exposure restores antibiotic susceptibility

Author(s): Chowdhury FR; Findlay BL;

Background: The prevalence of antibiotic resistance continues to rise, rendering many valuable antimicrobial drugs ineffective. Pairwise cyclic antibiotic therapy, where treatment is rapidly switched between two antibiotics, has been demonstrated in vitro to limit the evolution of antibiotic resistance. However, what happens when resistance inevitably evo ...

Article GUID: 41060280


Enhancing X-ray Activated Photodynamic Therapy with Supported Lipid Bilayer-Coated Radioluminescent Nanoparticles

Author(s): Bondon N; Mandl GA; Mena-Giraldo P; Ferron Z; Sadeghipour N; DeWolf C; Capobianco JA;

We report the synthesis of supported lipid bilayer (SLB)-coated radioluminescent nanoparticles (RLNPs) possessing a lanthanide-based core for low-dose X-ray activated photodynamic therapy (XPDT). Methylene blue (MB) photosensitizer molecules, incorporated within the SLB, are excited by energy transfer from europium, leading to an enhanced generation of re ...

Article GUID: 41059546


Finding a Link Between the TRPV4 Ion Channel and Angiogenesis: A Potential Therapeutic Target for Vascular Remodeling

Author(s): Malka G; Salucci V; Bergdahl A;

Angiogenesis, the formation of new blood vessels, is crucial in ischemic heart disease to improve blood supply to the heart. Meanwhile, in cancer, inhibiting angiogenesis can limit tumor growth by reducing oxygen and nutrients. Calcium ions, key in cellular functions like proliferation and migration, play an important role in this process. TRPV4, a calciu ...

Article GUID: 41056565


Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors

Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT;

Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological, and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to iden ...

Article GUID: 41056215


A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity

Author(s): Pierre Bikorimana J; Caveney NA; El-Hachem N; Mandl GA; Capobianco JA; Stanga D; Abusarah J; Hancock MA; Farah R; Gonçalves MP; Falzarano D; Liao M; Hamonic G; Liu Q; Beaudoin S; Talbot S; Rafei M;

Despite the recent control of COVID-19, the devastating effects caused by the 3-year pandemic highlight the importance of developing effective vaccines to rapidly address future outbreaks. The present study describes a novel Spike (Sp) protein-based vaccine formulation using the Accum platform. A ...

Article GUID: 41054531


Pseudocapacitive MXene@Fe-TA ternary mediator enhances denitrification via optimized electron transfer and microbial regulation in wastewater treatment

Author(s): Pan S; Wang X; Guo T; An H; Guo Y; Chen Z; Lian J; Guo J;

Inefficient electron transfer is one of the main challenges in practical denitrification applications. To address this issue, a novel ternary mediator functional material (Mxene@Fe-TA) was successfully synthesized, which exhibited pseudocapacitive properties to facilitate electron mediation and distribution. Batch experiments revealed that 50 mg/L MXene@F ...

Article GUID: 41043789


Understanding COVID-19 vaccination disparity among Black adults in North America: A two-study motivational approach

Author(s): Fang X; Holding AC; Audet ÉC; Thai H; Koestner R;

Previous research has revealed lower vaccination rates among Black communities relative to other racial-ethnic communities in North America. However, there remains a gap in understanding the motivational barriers contributing to these persistent disparities. Grounded in Self-Determination Theory, the current research aimed to examine the effects of differ ...

Article GUID: 41043306


A year of nouns from English-learning infants daily lives: The SEEDLingS-Nouns dataset

Author(s): Kalenkovich E; Koorathota S; Tor S; Amatuni A; Egan-Dailey S; Moore C; Laing C; Garrison H; Baudet G; Bulgarelli F; Uner S; Righter L; Bergelson E;

This paper describes a dataset consisting of manually annotated nouns from a corpus of longitudinal day-long audio and hour-long video recordings collected monthly from 44 babies from age 6 months to age 17 months. This dataset was created as part of a larger project, called SEEDLingS, that exami ...

Article GUID: 41034519


Mapping the distribution of contaminants identified by non-targeted screening of passively sampled urban air

Author(s): Liu L; Gillet AP; Akiki C; Tian L; Ma Y; Zhang X; Bowman DT; Wania F; Delbès G; Apparicio P; Bayen S;

Air pollution is closely associated with increased lung cancer incidence and mortality. Because many semi-volatile industrial chemicals, pesticides and combustion by-products are endocrine-disrupting or genotoxic, their mixtures in outdoor urban air, even at trace levels, could have cumulative ef ...

Article GUID: 41033295


Auditory Training for Everyday Functioning in Later Life

Author(s): Li KZH; Campos J; Pichora-Fuller MK;

Following from the World Health Organization's consideration of multiple systems (e.g., sensory, motor, and cognitive) in defining healthy aging, this study presents a review of research on training that has the primary goal of improving complex multitasking outcomes that approximate the everyday contexts in which hearing is important, whether or not ...

Article GUID: 41036263


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