Author(s): Paez A; Dogaheh SB; Gillman SO; Carnes A; Dakterzada F; Barbe F; Piñol-Ripoll G; Dang-Vu TT;

Background: Sleep is essential for brain-health, including clearance of ß-amyloid (Aß), tau, and otherpromising diagnostic markers of neurodegeneration and progression in Alzheimer's Disease (AD): cerebrospinal fluid neurofilament-light chain (NfL), neurogranin-36 (NG-36), and Chitinase-3-lik ...

Article GUID: 41512123

Author(s): Paez A; Piñol-Ripoll G; Dogaheh SB; Gillman SO; Dakterzada F; Carnes A; Barbe F; Dang-Vu TT;

Background: Cerebrospinal fluid (CSF) orexin levels are higher in MCI and AD and associated with sleep deterioration, increasing risk of cognitive decline and Alzheimer's disease (AD) progression. Orexin-A is a key sleep-wake cycle regulator. Dual orexin receptor antagonists improve sleep in ...

Article GUID: 41512277

Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; ...

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD). Tau pathology can be characterized in terms of spatial extent of tauopathy (SEOT) or load using sta ...

Article GUID: 41512332

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified as ...

Article GUID: 41511416

Author(s): Spiegler P; Harirpoush A; Xiao Y;

Crucial in disease analysis and surgical planning, manual segmentation of volumetric medical scans (e.g. MRI, CT) is laborious, error-prone, and challenging to master, while fully automatic algorithms can benefit from user feedback. Therefore, with the complementary power of the latest radiological AI foundation models and virtual reality (VR)'s intui ...

Article GUID: 41509996

Author(s): Borges C; Darecka A; Mainville-Berthiaume A; Ah-Yen E; Darvishmolla M; Courtemanche R; Shalev U;

Abstinence from drug use is often the result of the associated negative consequences. However, relapse occurs in a large proportion of abstinent users, and the underlying brain mechanisms are not clear. An arguably relevant brain area is the posterior paraventricular nucleus of the thalamus (pPVT ...

Article GUID: 41506524

Author(s): Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J;

Article GUID: 41507623

Author(s): Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF;

This secondary analysis examined the association between preexisting mental health conditions and clinical recovery trajectories in adolescents with concussion. Adolescents (13-17; n = 1238) completed clinical assessments (Post-Concussion Symptom Inventory [PCSI] =48 hours postinjury; PCSI/ Pediatric Quality of Life [PedsQL] for 3 months) and were categor ...

Article GUID: 41505351

Author(s): Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;

Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from a ...

Article GUID: 41504601

Author(s): Moritz A; Ezzati M; Gélinas Y;

Iron hydroxides play a key role in the preservation of organic matter in soils and sediments, yet the specificity and extent of their interactions with lignin-derived phenols-important source indicators for terrestrial organic matter-remain poorly understood in aquatic systems. In this study, we analyzed surface and downcore sediments along the terrestria ...

Article GUID: 41500137

Author(s): Foroughi S; Habibi M; Packirisamy M;

Proximal Sound Printing (PSP) is a new class of additive manufacturing (AM) processes where on-demand polymerization occurs through ultrasound waves interacting with printing material right at the proximity of the acoustic aperture by inducing cavitation. Despite recent developments in sound-based AM techniques, inherent practical limitations still remain ...

Article GUID: 41500993