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Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Author(s): Tikoo S; Noronha AM; Wilds CJ;

In this study, we report the synthesis of an alkylene linker containing a terminal 2-cyanoethyl protected selenium functionality for coupling at the 5'-end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates. Upon deprotection and cleavage from the solid support, quantitative formation of a 5'-diselen ...

Article GUID: 42322227


Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer s disease

Author(s): Perovic M; Phillips NA; Einstein G;

Introduction: Women make up two-thirds of people with Alzheimer's disease (AD). Research has focused on biological explanations for this sex difference, while contributions of psychosocial risk factors are less well understood. Methods: We examined sex differences in the effects of adverse childhood experiences (ACEs) on late-life cognition in grou ...

Article GUID: 42325010


From Sparse Nanoparticles to Graded Interfaces: Beyond Classical Descriptions of LiF Growth on Organic Semiconductors

Author(s): Oliviera P; Maye F; Turak A;

Small-molecule π $\pi$ -conjugated semiconductors provide an ordered platform for probing interfacial mechanisms in organic optoelectronics, where device performance and stability are dominated by interface effects. Lithium fluoride, despite its widespread use as an interlayer, remains paradoxical: essential for high device efficiencies yet gover ...

Article GUID: 42316423


Foraging benefits of winning intergroup encounters in colobus monkeys

Author(s): Wikberg EC; Lucci S; Glotfelty E; Campos F; Sicotte P;

Winners of aggressive intergroup encounters are often assumed to benefit from increased access to resources, but few studies have measured whether there is differential access to resources based on the intergroup outcome. To investigate whether winning intergroup encounters is associated with increased access to food, we used 13 months of data on interg ...

Article GUID: 42310246


Microsphere-Templated Conductive Syntactic Foams for Recyclable and Additively Manufactured Soft Electronics

Author(s): Petrossian G; Diouri Y; Xu B; Ebrahimi S; Pande A; Miquet-Westphal F; Xu H; Cicoira F;

Soft, conductive materials that simultaneously offer mechanical compliance, electrical conductivity, recyclability, and scalable manufacturing remain difficult to achieve. Here, we introduce recyclable, 3D-printable PEDOT:PSS syntactic foams based on polymer microspheres coated in situ, enabling precise control over porosity, mechanical properties, and ...

Article GUID: 42310993


An integrated external communication framework (ECF) for wheelchair design: linking primary user requirements with perceptual dimensions

Author(s): Rasoulivalajoozi M; Farhoudi M;

Purpose: Wheelchairs should support not only safe and intuitive navigation but also positive social presence without reinforcing disability-related stereotypes. This study introduces a user-centred external communication framework (ECF) to guide the design of wheelchair external human-machine interfaces and their perceptual dimensions.Materials and meth ...

Article GUID: 42300838


Indigenous Research Sovereignty Within Academia: Challenges and Opportunities

Author(s): Sophie J Blackmore

Indigenous Peoples' inherent right to self-determination includes authority over research, yet university systems centralize control in ways that constrain Indigenous sovereignty. This article examines how academic institutional structures and processes-well beyond the actions of individual researchers-shape the possibilities and limitations of Indi ...

Article GUID: 42294510


Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry

Author(s): Nikolic M; Caswell CB; Prada NP; Iqbal M; Cox SML; Jaworska N; Castellanos-Ryan N; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M;

Background: We recently reported evidence that a biopsychosocial model predicts lifetime histories of commonly comorbid early-onset psychiatric disorders. This transdiagnostic model was produced when incorporating either positron emission tomography-measured midbrain dopamine autoreceptors or f ...

Article GUID: 42293407


Development of a novel macroporous passive sampler with integrated solid phase extraction for cost-effective water contaminant monitoring

Author(s): Chen K; Shi S; Wen Y; Song M; Zhang X; Ma H; Tian X; Han X; Chen W; Chen Z; Sun J;

Passive samplers, for instance Chemcatcher, Microporous Polyethylene Tube passive samplers (MPTs) and Diffusive Gradients in Thin Films (DGT), are widely used for monitoring time-weighted average concentrations (CTWA) of contaminants in waters. This study presents ChemTRAP, a novel passive sampler using two macroporous filters (MFs) as both sorbent supp ...

Article GUID: 42284777


On the Implementation of a Compact Vertical DC Biasing Network with Significantly Reduced RF Components for Phase-Shifter-Free Beam Steering

Author(s): Zheng S; Qian B; Chen X; Kishk AA;

Dense direct-current (DC) bias routing and numerous radio-frequency (RF) choke inductors pose major challenges to the practical implementation of phase-shifter-free beam steering using PIN-controlled phase switching. To address this issue, a compact vertical DC biasing network is proposed, in which most DC bias lines are routed beneath the ground plane. ...

Article GUID: 42281100


From Rapid Reviews to Rapid Living Evidence Synthesis: Lessons From COVID-19 Vaccine Effectiveness Reviews for Canadian Public Health Decision-Making

Author(s): Wu N; Joyal-Desmarais K; Linkins LA; Flórez ID; Bacon SL;

Background: The COVID-19 pandemic demanded evidence synthesis approaches that could keep pace with rapidly evolving science and urgent policy needs. Rapid reviews and living evidence syntheses (LES) emerged as critical methodological responses, yet limited guidance exists for teams undertaking such work, particularly regarding the operational challenges ...

Article GUID: 42282099


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