Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and metabolic alterations in the brain remain poorly understood. Prior work has identified regional deficits ...

Article GUID: 41452711

Author(s): Paez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbe F; Dang-Vu TT; Piñol-Ripoll G;

Background: Sleep plays vital roles in brain-health and cognition, including regulating clearance of ß-amyloid (Aß) and tau proteins that hallmark Alzheimer's disease (AD). Changes in sleep physiology can predate cognitive symptoms by decades in AD, but it remains unclear which sleep characte ...

Article GUID: 41452500

Author(s): Marinou S; Phillips NA;

Background: Subjective cognitive decline (SCD) is defined as a self-perceived decline in cognition without objective cognitive impairment and is considered a potential predictor of Alzheimer's disease (AD). However, summary-level neuropsychological test scores often fail to detect subtle cognitive changes in this group, making assessments challenging. ...

Article GUID: 41448190

Author(s): Mancor E; Montero-Odasso M; Bherer L; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Li K;

Background: Cognitive and motor deficits have been found to be important markers of Mild Cognitive Impairment (MCI), a pre-dementia risk state. Recently, aerobic exercise (AE) and cognitive training (CT) interventions significantly improved cognitive and motor function in older adults with MCI. R ...

Article GUID: 41448628

Author(s): Cunningham NP; Tremblay-Mercier J; Baril AA; Dang-Vu TT; Lim A; Geddes MR; Badawy M; Poirier J; Ducharme S; Villeneuve S;

Background: Poor sleep is a modifiable factor associated with the development and progression of Alzheimer's Disease (AD). Pharmacological treatments and Cognitive Behavioural Therapy for Insomnia (CBT-I) which promote sleep have the potential to improve AD risk profile. In addition, prior re ...

Article GUID: 41450269

Author(s): Hollett KB; Morin AJS; Carrese-Chacra E; Cohen TR; Carbonneau N; Berthiaume MM; Felice E; Gouin JP;

Socioecological models of health view romantic relationships as micro-social systems in which spouses influence one another's health-related thoughts, feelings, and behaviors. Although prior work suggests spousal interdependence in eating behaviors, the degree of interdependence may vary as a ...

Article GUID: 41448461

Author(s): Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L;

Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to g ...

Article GUID: 41447475

Author(s): Rehan S; Mehrabi F; Mick P; Phillips NA;

Background: Sensory and psychosocial factors are potentially modifiable risk factors for dementia. Social factors and indicators of mental health are associated with cognitive performance and risk for Alzheimer's disease (AD). Sensory impairment can lead to communication and mobility difficulties, reducing social engagement and possibly accelerating c ...

Article GUID: 41447555

Author(s): Sorin C; Phillips NA;

Background: During the COVID-19 pandemic, older adults were considered vulnerable to declines in well-being, especially those with preexisting cognitive impairments. However, qualitative studies have focused on the resilience of cognitively-unimpaired older adults during the pandemic. Therefore, the present study employed both quantitative and qualitative ...

Article GUID: 41447242

Author(s): Jobin B; Frasnelli J; Phillips NA; Boller B;

Background: Olfactory identification is impaired early in the clinical continuum of Alzheimer's disease (AD) and is already observable in mild cognitive impairment (MCI). A recent meta-analysis showed significant associations between olfactory identification and episodic memory scores in older adults without cognitive impairment. Thus, olfactory ident ...

Article GUID: 41443638

Author(s): Grant N; Phillips NA;

Background: Age-related hearing loss (HL) is associated with poorer cognition and increased risk of developing dementia. However, few studies have explored if sex affects the association between HL and cognition. We investigated the relationship between two hearing measures and performance on cognitive screening and neuropsychological tests in males and f ...

Article GUID: 41443651