Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620

Author(s): Lebel H; Rochefort D; Lai C; Boulanger T; Debiais A; Hamlet L; Maleki M; Goulet MA;

Aqueous organic redox flow batteries (AORFBs) are a safe and sustainable solution for the storage of intermittent renewable energy. While several highly soluble two-electron organic molecule negolytes have been developed for AORFBs, most reported organic posolyte species exchange only one electron. Herein, readily available 4,4'-hydrazobis(1-methylpyr ...

Article GUID: 40357731

Author(s): Paine AL; Hashmi S; Fink E; Mitchell P; Howe N;

Humour plays a crucial role in children's early interactions, likely promoting the development of social understanding and fostering positive social relationships. To date, the connection between humour production in peer play and the development of social understanding skills in middle childhood has received limited attention. In a community sample o ...

Article GUID: 40355511

Author(s): Rousseau PN; Bazin PL; Steele CJ;

The cerebellum's involvement in a range of cognitive, emotional, and motor processes has become increasingly evident. Given the uniformity of the cerebellar cortex's cellular architecture its contributions to varied processes are thought be partially mediated by its patterns of reciprocal connectivity with the rest of the brain. A better understan ...

Article GUID: 40355513

Author(s): Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None;

Alzheimer's disease (AD) is a complex disease that involves complex interactions between protein biomarkers such as amyloid beta (Aß) and tau, neurodegeneration, cerebrovascular health and inflammation. However, how these factors interact, especially in the early phases of disease development ...

Article GUID: 40347524

Author(s): Goldman EJ; Baumann AE; Pare L; Beaudoin J; Poulin-Dubois D;

The present work examined children's attribution of psychological properties to inanimate agents in two experiments. In Study 1, an Interview Task and the Theory of Mind Scale (ToM Scale) were administered to 4-year-olds with either a human or a humanoid robot (NAO) protagonist. Parents also completed the Children's Social Understanding Scale (CSU ...

Article GUID: 40348850

Author(s): Chen SJ; Ivers H; Dang-Vu TT; Shapiro CM; Carney CE; Robillard R; Morin CM;

Introduction: Insomnia is a prevalent yet under-characterized disorder, particularly regarding the heterogeneity of patients and their associated responses to different treatment modalities. This often leads to suboptimal management. There is a need to consider personalized approaches tailored to the characteristics of insomnia phenotypes with regard to o ...

Article GUID: 40346496

Author(s): Lazzari G; Costantini G; La Rocca S; Massironi A; Cattaneo L; Penhune V; Lega C;

Humans can flexibly extract a regular beat from complex rhythmic auditory patterns, as often occurs in music. Contemporary models of beat perception suggest that the premotor cortex (PMC) and the supplementary motor area (SMA) are integral to this process. However, how these motor planning regions actively contribute to beat perception, along with any pot ...

Article GUID: 40344601

Author(s): LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN;

Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which occur response-independently and signal that a seeking action will produce reward. Metabotropic group II glutamate (mGlu2/3) receptors i ...

Article GUID: 40341317

Author(s): Murch WS; Scheurich R; Monson E; French M; Kairouz S;

The Problem Gambling Severity Index (PGSI) is a popular tool for assessing past-year problems related to gambling. Multiple categorization schemes have been proposed, with scores 3-7 variously interpreted as reflecting a 'moderate' degree of problems. Crucially, it is possible to land in this Moderate-risk category by reporting one or two persiste ...

Article GUID: 40338426