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SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation

Author(s): Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M;

SAGA (Spt-Ada-Gcn5-acetyltransferase) is a highly conserved, multiprotein co-activator complex that consists of five distinct modules. It has two enzymatic functions, a histone acetyltransferase (HAT) and a deubiquitinase (DUB) and plays a central role in processes such as transcription initiation, elongation, protein stability, and telomere maintenance. ...

Article GUID: 35350439


Validation of desk-based audits using Google Street View® to monitor the obesogenic potential of neighbourhoods in a pediatric sample: a pilot study in the QUALITY cohort

Author(s): Roberge JB; Contreras G; Kakinami L; Van Hulst A; Henderson M; Barnett TA;

Background: The suitability of geospatial services for auditing neighbourhood features relevant to pediatric obesity remains largely unexplored. Our objectives were to (i) establish the measurement properties of a desk-based audit instrument that uses Google Street View ® to assess street- and neighbourhood-level features relevant to pediatric obesity (QU ...

Article GUID: 35346220


The effects of simulated and actual visual impairment on the Montreal Cognitive Assessment

Author(s): Stark Z; Morrice E; Murphy C; Wittich W; Johnson AP;

Many cognitive assessments include a visual component; however, adults may experience a decline in visual acuity with age. Scores on cognitive assessments of adults with visual impairments are typically lower than adults with normal vision, however, it is unclear if these lower scores are a consequence of cognitive or visual impairment. We measured the im ...

Article GUID: 35341447


Inclusion of currently diagnosed or treated individuals in studies of depression screening tool accuracy: a meta-research review of studies published in 2018-2021

Author(s): Nassar EL; Levis B; Rice DB; Booij L; Benedetti A; Thombs BD;

Objectives: Screening is done to improve health outcomes by identifying and effectively treating individuals with unrecognized conditions. Depression screening has been proposed to identify previously unrecognized depression cases. Including individuals already diagnosed or treated for depression in screening test accuracy studies could exaggerate accurac ...

Article GUID: 35334411


Frailty, e-health and prevention of late-onset Alzheimer disease and related disorders: it is time to take action

Author(s): Beauchet O; Galery K; Lafontaine C; Sawchuk K; Plonka A; Gros A; Allali G;

No abstract

Article GUID: 35334089


Sentiment Classification Method Based on Blending of Emoticons and Short Texts

Author(s): Zou H; Xiang K;

With the development of Internet technology, short texts have gradually become the main medium for people to obtain information and communicate. Short text reduces the threshold of information production and reading by virtue of its short length, which is in line with the trend of fragmented reading in the context of the current fast-paced life. In additi ...

Article GUID: 35327909


Supplementary dataset of context-dependent conditioned responding to an alcohol-predictive cue in female and male rats

Author(s): Segal D; Valyear MD; Chaudhri N;

This supplementary dataset is supportive of the research article entitled 'The role of context on responding to an alcohol-predictive cue in female and male rats' [1]. This article describes the raw data pertaining to the behaviour of male and female rats during intermittent to ethanol and Pavlovian conditioning training and testing procedures. Sp ...

Article GUID: 35330738


A portrait of obstructive sleep apnea risk factors in 27,210 middle-aged and older adults in the Canadian Longitudinal Study on Aging

Author(s): Thompson C; Legault J; Moullec G; Baltzan M; Cross N; Dang-Vu TT; Martineau-Dussault MÈ; Hanly P; Ayas N; Lorrain D; Einstein G; Carrier J; Gosselin N;

Determining the prevalence and characteristics of individuals susceptible to present with obstructive sleep apnea (OSA) is essential for developing targeted and efficient prevention and screening strategies. We included 27,210 participants aged =45 years old (50.3% women) from the Canadian Longit ...

Article GUID: 35332170


Should Burnout Be Conceptualized as a Mental Disorder?

Author(s): Nadon L; De Beer LT; Morin AJS;

Burnout is generally acknowledged by researchers, clinicians, and the public as a pervasive occupational difficulty. Despite this widespread recognition, longstanding debates remain within the scientific community regarding its definition and the appropriateness of classifying burnout as its own pathological entity. The current review seeks to address whe ...

Article GUID: 35323401


Dynamics of SARS-CoV-2 spreading under the influence of environmental factors and strategies to tackle the pandemic: A systematic review

Author(s): Asif Z; Chen Z; Stranges S; Zhao X; Sadiq R; Olea-Popelka F; Peng C; Haghighat F; Yu T;

COVID-19 is deemed as the most critical world health calamity of the 21st century, leading to dramatic life loss. There is a pressing need to understand the multi-stage dynamics, including transmission routes of the virus and environmental conditions due to the possibility of multiple waves of COVID-19 in the future. In this paper, a systematic examinatio ...

Article GUID: 35317188


Combination of system biology and classical approaches for developing biorefinery relevant lignocellulolytic Rasamsonia emersonii strain

Author(s): Raheja Y; Singh V; Kaur B; Basotra N; Di Falco M; Tsang A; Singh Chadha B;

The objective of this study was to develop thermophilic fungus Rasamsonia emersonii using integrated system biology tools (genomics, proteomics and transcriptional analysis) in combination with classical strain breeding approaches. Developed hyper cellulolytic mutant strain M36 showed endoglucanase (476.35 U/ml), ß-glucosidase (70.54 U/ml), cellobiohydrol ...

Article GUID: 35318142


Human-level COVID-19 diagnosis from low-dose CT scans using a two-stage time-distributed capsule network

Author(s): Afshar P; Rafiee MJ; Naderkhani F; Heidarian S; Enshaei N; Oikonomou A; Babaki Fard F; Anconina R; Farahani K; Plataniotis KN; Mohammadi A;

Reverse transcription-polymerase chain reaction is currently the gold standard in COVID-19 diagnosis. It can, however, take days to provide the diagnosis, and false negative rate is relatively high. Imaging, in particular chest computed tomography (CT), can assist with diagnosis and assessment of ...

Article GUID: 35318368


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