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Effects of Transcranial Direct Current Stimulation on Attentional Bias to Methamphetamine Cues and Its Association With EEG-Derived Functional Brain Network Topology

Author(s): Khajehpour H; Parvaz MA; Kouti M; Hosseini Rafsanjani T; Ekhtiari H; Bakht S; Noroozi A; Makkiabadi B; Mahmoodi M;

Background: Although transcranial direct current stimulation (tDCS) has shown to potentially mitigate drug craving and attentional bias to drug-related stimuli, individual differences in such modulatory effects of tDCS are less understood. In this study, we aimed to investigate a source of the in ...

Article GUID: 35380672


Predicted coronavirus Nsp5 protease cleavage sites in the human proteome

Author(s): Scott BM; Lacasse V; Blom DG; Tonner PD; Blom NS;

Background: The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways involved in innate immunity. Nsp5 from the recently emerged SARS-CoV-2 vi ...

Article GUID: 35379171


Application of Machine Learning in the Reliability Evaluation of Pipelines for the External Anticorrosion Coating

Author(s): Zhao Z; Chen M; Fan H; Zhang N;

The purpose of this research is to enhance the analysis of the reliability status for external anticorrosive coatings. With the limitation and insufficiency of the static evaluation method, we study and construct an evaluation method of dynamic reliability for the anticorrosive layer, integrating the trend analysis of the Markov chain and the set pair the ...

Article GUID: 35371236


A Proposed Multi-Criteria Optimization Approach to Enhance Clinical Outcomes Evaluation for Diabetes Care: A Commentary

Author(s): Wan TTH; Matthews S; Luh H; Zeng Y; Wang Z; Yang L;

There are several challenges in diabetes care management including optimizing the currently used therapies, educating patients on selfmanagement, and improving patient lifestyle and systematic healthcare barriers. The purpose of performing a systems approach to implementation science aided by artificial intelligence techniques in diabetes care is two-fold ...

Article GUID: 35372638


Structural brain network topological alterations in stuttering adults

Author(s): Gracco VL; Sares AG; Koirala N;

Persistent developmental stuttering is a speech disorder that primarily affects normal speech fluency but encompasses a complex set of symptoms ranging from reduced sensorimotor integration to socioemotional challenges. Here, we investigated the whole-brain structural connectome and its topological alterations in adults who stutter. Diffusion-weighted ima ...

Article GUID: 35368614


Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin

Author(s): Wellman M; Budin R; Woodside B; Abizaid A;

Lactating rats show changes in the secretion of hormones and brain signals that promote hyperphagia and facilitate the production of milk. Little is known, however, about the role of ghrelin in the mechanisms sustaining lactational hyperphagia. Here, we used Wistar female rats that underwent surgery to sever the galactophores to prevent milk delivery (GC ...

Article GUID: 35365872


Arraying of microphotosynthetic power cells for enhanced power output

Author(s): Kuruvinashetti K; Packirisamy M;

Microphotosynthetic power cells (µPSCs) generate power through the exploitation of living photosynthetic microorganisms by harvesting sunlight. The thermodynamic limitations of this process restrict the power output of a single µPSC. Herein, we demonstrate µPSCs in four different array configurations to enhance power output from these power cells. To this ...

Article GUID: 35359612


Remediation of oil-contaminated soil using Fe/Cu nanoparticles and biosurfactants

Author(s): Vu KA; Mulligan CN;

BSTRACTOil (or petroleum), consisting of a mixture of hydrocarbons, can be leaked from oil exploration, production, and use. Due to their complex mixture and interaction with the subsurface soil and water, they are hard to treat and can become a significant environmental concern. Rhamnolipid and sophorolipid biosurfactants, biologically produced surfactan ...

Article GUID: 35361056


Sample size and precision of estimates in studies of depression screening tool accuracy: A meta-research review of studies published in 2018-2021

Author(s): Nassar EL; Levis B; Neyer MA; Rice DB; Booij L; Benedetti A; Thombs BD;

Objectives: Depression screening tool accuracy studies should be conducted with large enough sample sizes to generate precise accuracy estimates. We assessed the proportion of recently published depression screening tool diagnostic accuracy studies that reported sample size calculations; the proportion that provided confidence intervals (CIs); and precisi ...

Article GUID: 35362161


Low back pain definitions: effect on patient inclusion and clinical profiles

Author(s): Massé-Alarie H; Angarita-Fonseca A; Lacasse A; Pagé MG; Tétreault P; Fortin M; Léonard G; Stone LS; Roy JS;

Introduction: Numerous definitions of acute low back pain (aLBP) exist. The use of different definitions results in variability in reported prevalence or incidence, conflicting data regarding factors associated with the transition to chronic LBP (cLBP), and hampers comparability among studies. O ...

Article GUID: 35356510


SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation

Author(s): Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M;

SAGA (Spt-Ada-Gcn5-acetyltransferase) is a highly conserved, multiprotein co-activator complex that consists of five distinct modules. It has two enzymatic functions, a histone acetyltransferase (HAT) and a deubiquitinase (DUB) and plays a central role in processes such as transcription initiation, elongation, protein stability, and telomere maintenance. ...

Article GUID: 35350439


Validation of desk-based audits using Google Street View® to monitor the obesogenic potential of neighbourhoods in a pediatric sample: a pilot study in the QUALITY cohort

Author(s): Roberge JB; Contreras G; Kakinami L; Van Hulst A; Henderson M; Barnett TA;

Background: The suitability of geospatial services for auditing neighbourhood features relevant to pediatric obesity remains largely unexplored. Our objectives were to (i) establish the measurement properties of a desk-based audit instrument that uses Google Street View ® to assess street- and neighbourhood-level features relevant to pediatric obesity (QU ...

Article GUID: 35346220


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