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PubMed Publications| Keyword search (4,163 papers available) |  |
"oligonucleotides" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H | Pontarelli A; Wilds CJ; | 35452799 CHEMBIOCHEM |
| 2 | Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides | Holgersen EM; Gandhi S; Zhou Y; Kim J; Vaz B; Bogojeski J; Bugno M; Shalev Z; Cheung-Ong K; Gonçalves J; O' Hara M; Kron K; Verby M; Sun M; Kakaradov B; Delong A; Merico D; Deshwar AG; | 34388351 ENCS |
| 3 | Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications | Liczner C; Duke K; Juneau G; Egli M; Wilds CJ; | 33981365 CHEMBIOCHEM |
| 4 | Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. | Copp W, Pontarelli A, Wilds CJ | 33506614 CHEMBIOCHEM |
| 5 | O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage. | O'Flaherty DK, Wilds CJ | 26692563 CHEMISTRY |
| Title: | Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications | ||||
| Authors: | Liczner C, Duke K, Juneau G, Egli M, Wilds CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/33981365/ | ||||
| DOI: | 10.3762/bjoc.17.76 | ||||
| Publication: | Beilstein journal of organic chemistry | ||||
| Keywords: | antisense; chemically modified oligonucleotides; crystallography; siRNA; structure; | ||||
| PMID: | 33981365 | Category: | Date Added: | 2021-05-19 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada. 2 Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States. |
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Description: |
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their scaffold, prepared with modified nucleosides and solid-phase synthesis, have yielded molecules with interesting biophysical properties that bind to their targets and are tolerated by the cellular machinery to elicit a therapeutic outcome. Structural techniques, such as crystallography, have provided insights to rationalize numerous properties including binding affinity, nuclease stability, and trends observed in the gene silencing. In this review, we discuss the chemistry, biophysical, and structural properties of a number of chemically modified oligonucleotides that have been explored for gene silencing. |
