Keyword search (4,163 papers available)

"oligonucleotides" Keyword-tagged Publications:

Title Authors PubMed ID
1 Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H Pontarelli A; Wilds CJ; 35452799
CHEMBIOCHEM
2 Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides Holgersen EM; Gandhi S; Zhou Y; Kim J; Vaz B; Bogojeski J; Bugno M; Shalev Z; Cheung-Ong K; Gonçalves J; O' Hara M; Kron K; Verby M; Sun M; Kakaradov B; Delong A; Merico D; Deshwar AG; 34388351
ENCS
3 Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications Liczner C; Duke K; Juneau G; Egli M; Wilds CJ; 33981365
CHEMBIOCHEM
4 Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. Copp W, Pontarelli A, Wilds CJ 33506614
CHEMBIOCHEM
5 O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage. O'Flaherty DK, Wilds CJ 26692563
CHEMISTRY

 

Title:Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.
Authors:Copp WPontarelli AWilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/33506614
DOI:10.1002/cbic.202000835
Publication:Chembiochem : a European journal of chemical biology
Keywords:DNA nanotechnologybiosensorsdrug deliverynucleic acidsoligonucleotides
PMID:33506614 Category:Chembiochem Date Added:2021-01-29
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, H4B 1R6, Canada.

Description:

Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.

Chembiochem. 2021 Jan 27; :

Authors: Copp W, Pontarelli A, Wilds CJ

Abstract

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are of particular interest as these structures have been shown to be readily taken up by the cell without the need for transfecting agents via the process of caveolin mediated endocytosis. Moreover, these structures can be readily modified with a diverse range of pendant groups to confer greater functionality. This minireview highlights recent examples of advances related to applications of this interesting DNA structure including the delivery of therapeutic agents ranging from small molecules to oligonucleotides in addition to its utilization for sensing and imaging of various species within the cell.

PMID: 33506614 [PubMed - as supplied by publisher]





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