Keyword search (4,163 papers available)

"genetics" Keyword-tagged Publications:

Title Authors PubMed ID
1 Smart Optogenetics for Real-Time Automated Control of Cardiac Electrical Activity Deng S; Harlaar N; Zhang J; Dekker SO; Kudryashova NN; Zhou H; Bart CI; Jin T; Derevyanko G; van Driel W; Panfilov AV; Poelma RH; de Vries AAF; Zhang G; De Coster T; Pijnappels DA; 41684280
CHEMBIOCHEM
2 Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M; 41558814
BIOLOGY
3 Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in em Caenorhabditis elegans, /em challenges a proposed role in heme trafficking Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ; 41504601
BIOLOGY
4 Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; 41372546
PSYCHOLOGY
5 Disentangling prediction error and value in a formal test of dopamine s role in reinforcement learning Usypchuk AA; Maes EJP; Lozzi M; Avramidis DK; Schoenbaum G; Esber GR; Gardner MPH; Iordanova MD; 40738112
CSBN
6 Single-cell imaging of protein dynamics of paralogs reveals sources of gene retention Dandage R; Papkov M; Greco BM; Pereira V; Fishman D; Friesen H; Wang K; Styles EB; Kraus O; Grys B; Zapata G; Lefebvre F; Bourque G; Boone C; Andrews BJ; Parts L; Kuzmin E; 40585364
BIOLOGY
7 SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis Bögershausen N; Cavdarli B; Nagai T; Milev MP; Wolff A; Mehranfar M; Schmidt J; Choudhary D; Gutiérrez-Gutiérrez Ó; Cyganek L; Saint-Dic D; Zibat A; Köhrer K; Wollenweber TE; Wieczorek D; Altmüller J; Borodina T; Kaçar D; Haliloglu G; Li Y; Thiel C; Sacher M; Knapik EW; Yigit G; Wollnik B; 40131364
BIOLOGY
8 Shared Dispersal Patterns but Contrasting Levels of Gene Flow in Two Anadromous Salmonids Along a Broad Subarctic Coastal Gradient Bouchard R; Babin C; Normandeau E; Xuereb A; Boulanger F; Coxon A; Diamond S; Fireman R; Lameboy J; Louttit N; Natawapineskum G; Okimaw D; Torio D; Varty S; Moore JS; Fraser D; Bernatchez L; 40108992
CONCORDIA
9 Temporal Variability in Effective Size ( [Formula] ) Identifies Potential Sources of Discrepancies Between Mark Recapture and Close Kin Mark Recapture Estimates of Population Abundance Ruzzante DE; McCracken GR; Fraser DJ; MacMillan J; Buhariwalla C; Flemming JM; 39582254
BIOLOGY
10 Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles Rezaei M; Liang M; Yalcin Z; Martin JH; Kazemi P; Bareke E; Ge ZJ; Fardaei M; Benadiva C; Hemida R; Hassan A; Maher GJ; Abdalla E; Buckett W; Bolze PA; Sandhu I; Duman O; Agrawal S; Qian J; Vallian Broojeni J; Bhati L; Miron P; Allias F; Selim A; Fisher RA; Seckl MJ; Sauthier P; Touitou I; Tan SL; Majewski J; Taketo T; Slim R; 39545410
BIOLOGY
11 What can optimized cost distances based on genetic distances offer? A simulation study on the use and misuse of ResistanceGA Daniel A; Savary P; Foltête JC; Vuidel G; Faivre B; Garnier S; Khimoun A; 39417711
BIOLOGY
12 Global assessment of effective population sizes: Consistent taxonomic differences in meeting the 50/500 rule Clarke SH; Lawrence ER; Matte JM; Gallagher BK; Salisbury SJ; Michaelides SN; Koumrouyan R; Ruzzante DE; Grant JWA; Fraser DJ; 38613250
BIOLOGY
13 Macrogenetics reveals multifaceted influences of environmental variation on vertebrate population genetic diversity across the Americas Lawrence ER; Pedersen EJ; Fraser DJ; 37365672
BIOLOGY
14 Demographic resilience of brook trout populations subjected to experimental size-selective harvesting Clarke SH; McCracken GR; Humphries S; Ruzzante DE; Grant JWA; Fraser DJ; 36426123
BIOLOGY
15 Potential epigenetic mechanisms in psychotherapy: a pilot study on DNA methylation and mentalization change in borderline personality disorder Quevedo Y; Booij L; Herrera L; Hernández C; Jiménez JP; 36171872
PSYCHOLOGY
16 DNA methylation as a mediator in the association between prenatal maternal stress and child mental health outcomes: Current state of knowledge Azar N; Booij L; 36113690
PSYCHOLOGY
17 Population demography maintains biogeographic boundaries Schmidt C; Muñoz G; Lancaster LT; Lessard JP; Marske KA; Marshall KE; Garroway CJ; 35753949
BIOLOGY
18 DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É; 35703085
PSYCHOLOGY
19 Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics Abicumaran Uthamacumaran 35678918
PHYSICS
20 Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders? Breton E; Fotso Soh J; Booij L; 35594735
PSYCHOLOGY
21 Corticostriatal suppression of appetitive Pavlovian conditioned responding Villaruel FR; Martins M; Chaudhri N; 34880119
PSYCHOLOGY
22 The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch's law Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P; 34864162
PSYCHOLOGY
23 Location and Species Matters: Variable Influence of the Environment on the Gene Flow of Imperiled, Native and Invasive Cottontails McGreevy TJ; Michaelides S; Djan M; Sullivan M; Beltrán DM; Buffum B; Husband T; 34659333
BIOLOGY
24 Seeing is believing: tools to study the role of Rho GTPases during cytokinesis Koh SP; Pham NP; Piekny A; 34405757
BIOLOGY
25 All-optical approaches to studying psychiatric disease Lafferty CK; Christinck TD; Britt JP; 34314828
CSBN
26 Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review. Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L; 33221025
PSYCHOLOGY
27 The Relationship Between Cognitive Status and Known Single Nucleotide Polymorphisms in Age-Related Macular Degeneration. Murphy C; Johnson AP; Koenekoop RK; Seiple W; Overbury O; 33178008
PSYCHOLOGY
28 A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function. Al-Deri N, Okur V, Ahimaz P, Milev M, Valivullah Z, Hagen J, Sheng Y, Chung W, Sacher M, Ganapathi M 32843486
BIOLOGY
29 DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents. Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L 32479312
PSYCHOLOGY
30 Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice. Steiger H, Booij L 32375223
PSYCHOLOGY
31 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
32 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
33 The Neuroscience of Sadness: A Multidisciplinary Synthesis and Collaborative Review for the Human Affectome Project. Arias JA, Williams C, Raghvani R, Aghajani M, Baez S, Belzung C, Booij L, Busatto G, Chiarella J, Fu CH, Ibanez A, Liddell BJ, Lowe L, Penninx BWJH, Rosa P, Kemp AH 32001274
PSYCHOLOGY
34 Methylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior. Thaler L, Brassard S, Booij L, Kahan E, McGregor K, Labbe A, Israel M, Steiger H 31823473
PSYCHOLOGY
35 Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Collins F, Willis MJH, Coban Akdemir ZH, Liu P, Punetha J, Hunter JV, Jhangiani SN, Fatih JM, Rosenfeld JA, Posey JE, Gibbs RA, Karaca E, Massey S, Ranasinghe TG, Sleiman P, Troedson C, Lupski JR, Sacher M, Segev N, Hakonarson H, Christodoulou J 31794024
BIOLOGY
36 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
37 Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value. Mendoza JA, Lafferty CK, Yang AK, Britt JP 31693885
CSBN
38 Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 28032437
PSYCHOLOGY
39 A critical assessment of estimating census population size from genetic population size (or vice versa) in three fishes. Yates MC, Bernos TA, Fraser DJ 29151884
BIOLOGY
40 Genetic diversity of small populations: Not always "doom and gloom"? Fraser DJ 29243868
BIOLOGY

 

Title:Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.
Authors:Yang AKMendoza JALafferty CKLacroix FBritt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31699294?dopt=Abstract
DOI:10.1016/j.biopsych.2019.09.007
Publication:Biological psychiatry
Keywords:Feeding behaviorHedonic processingHippocampusNucleus accumbensOptogeneticsPalatability
PMID:31699294 Category:Biol Psychiatry Date Added:2019-11-09
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Psychology, McGill University, Montreal, Quebec, Canada.
4 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Biol Psychiatry. 2019 Sep 19;:

Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Abstract

BACKGROUND: Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown.

METHODS: Bidirectional optogenetic manipulations were targeted to the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays. Number of licks per bout of consumption was used as a measure of food palatability as it was confirmed to track sucrose concentration and subjective flavor preferences.

RESULTS: Photoinhibition of NAcSh neurons, whether general or cell-type specific, was found to alter consumption without affecting its hedonic impact. Among the principal excitatory afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability upon low-frequency photostimulation time-locked to consumption. This enhancement in palatability was independent of opioid signaling and not recapitulated by NAcSh or dopamine neuron photostimulation. We further demonstrated that vHipp input photostimulation is sufficient to condition a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

CONCLUSIONS: These results demonstrate a novel contribution of vHipp-NAcSh pathway activity to palatability that may relate to its innervation of a particular region or neuronal ensemble in the NAcSh. These findings are consistent with the evidence that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appreciation of hippocampal involvement in people's food pleasantness ratings, hunger, and weight.

PMID: 31699294 [PubMed - as supplied by publisher]





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