PERFORM Publications

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Title		Authors	PubMed ID
1	De novo evolution of antibiotic resistance to Oct-TriA1	Chowdhury FR; Mercado LD; Kharitonov K; Findlay BL;	39832423 BIOLOGY
2	In Silico Study of the Early Stages of Aggregation of β-Sheet Forming Antimicrobial Peptide GL13K	Hamidabad MN; Watson NA; Wright LN; Mansbach RA;	38572930 PHYSICS
3	Tide-induced infiltration and resuspension of microplastics in shorelines: Insights from tidal tank experiments	Feng Q; Chen Z; An C; Yang X; Wang Z;	37084574 ENCS
4	Oligonucleotides Containing C5-Propynyl Modified Arabinonucleic Acids: Synthesis, Biophysical and Antisense Properties	Pontarelli A; Wilds CJ;	36857293 CHEMBIOCHEM
5	Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides	Pontarelli A; Liu JT; Oh JK; Wilds CJ;	36840706 CHEMBIOCHEM
6	Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts	Caspari OD; Garrido C; Law CO; Choquet Y; Wollman FA; Lafontaine I;	36733255 BIOLOGY
7	Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H	Pontarelli A; Wilds CJ;	35452799 CHEMBIOCHEM
8	Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides	Holgersen EM; Gandhi S; Zhou Y; Kim J; Vaz B; Bogojeski J; Bugno M; Shalev Z; Cheung-Ong K; Gonçalves J; O' Hara M; Kron K; Verby M; Sun M; Kakaradov B; Delong A; Merico D; Deshwar AG;	34388351 ENCS
9	Duplicated antagonistic EPF peptides optimize grass stomatal initiation	Jangra R; Brunetti SC; Wang X; Kaushik P; Gulick PJ; Foroud NA; Wang S; Lee JS;	34328169 BIOLOGY
10	Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex	Olajide OJ; Chapman CA;	34144329 PSYCHOLOGY
11	Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics	Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I;	34064722 BIOLOGY
12	Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications	Liczner C; Duke K; Juneau G; Egli M; Wilds CJ;	33981365 CHEMBIOCHEM
13	Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.	Copp W, Pontarelli A, Wilds CJ	33506614 CHEMBIOCHEM
14	Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts	Behmand B; Noronha AM; Wilds CJ; Marignier JL; Mostafavi M; Wagner JR; Hunting DJ; Sanche L;	32211848 CHEMBIOCHEM
15	Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans.	Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J	32075883 BIOLOGY
16	Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics.	Millet-Boureima C, Chingle R, Lubell WD, Gamberi C	31635379 BIOLOGY
17	Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial.	Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Janssen P, de Leede L, Meyer JJ, Everaerd W, Frijlink HW, Koppeschaar HP, Olivier B, Pfaus JG	30016917 CSBN
18	O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.	O'Flaherty DK, Wilds CJ	26692563 CHEMISTRY
19	TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.	Sacher M, Shahrzad N, Kamel H, Milev MP	30152084 BIOLOGY
20	Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae).	Bhagavathula N, Meedidoddi V, Bourque S, Vimaladevi R, Kesavakurup S, Selvadurai D, Shrivastava S, Krishnappa C	28346717 PERFORM

Title:	Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H
Authors:	Pontarelli A, Wilds CJ
Link:	https://pubmed.ncbi.nlm.nih.gov/35452799/
DOI:	10.1016/j.bmcl.2022.128744
Publication:	Bioorganic & medicinal chemistry letters
Keywords:	Arabino nucleic acids; C5-propynyl nucleosides; E coli RNase H; Modified oligonucleotides; Nuclease stability;
PMID:	35452799	Category:	Date Added:	2022-04-23
Dept Affiliation:	CHEMBIOCHEM 1 Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Rue Sherbrooke Ouest, Montréal, Québec, H4B 1R6, Canada. 2 Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Rue Sherbrooke Ouest, Montréal, Québec, H4B 1R6, Canada. Electronic address: Chris.Wilds@concordia.ca.

Description:

The promise of the antisense approach to treat a variety of diseases with oligonucleotides and solutions to challenges that have been encountered in their development is attributable to chemical modification of the nucleic acid scaffold. Herein, we describe preliminary data regarding the synthesis of a novel C5-propynyl-ß-D-arabinouridine (araU^P) phosphoramidite and its incorporation into oligonucleotides. Substitution of araU^P in dT₁₈ results in minor stabilization of duplexes formed with RNA when modifications are placed consecutively and a uniformly modified araU^P 18-mer increases stability by 34 °C relative to DNA. The modified oligomer exhibits improved nuclease and serum stability when compared to DNA and duplexes formed between RNA and araU^P oligonucleotides are substrates for E. coli RNase H. These preliminary results merit further investigation into C5-propynyl modified arabino nucleic acids for potential therapeutic gene silencing applications.

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