Keyword search (4,163 papers available)

"Tide" Keyword-tagged Publications:

Title Authors PubMed ID
1 De novo evolution of antibiotic resistance to Oct-TriA1 Chowdhury FR; Mercado LD; Kharitonov K; Findlay BL; 39832423
BIOLOGY
2 In Silico Study of the Early Stages of Aggregation of β-Sheet Forming Antimicrobial Peptide GL13K Hamidabad MN; Watson NA; Wright LN; Mansbach RA; 38572930
PHYSICS
3 Tide-induced infiltration and resuspension of microplastics in shorelines: Insights from tidal tank experiments Feng Q; Chen Z; An C; Yang X; Wang Z; 37084574
ENCS
4 Oligonucleotides Containing C5-Propynyl Modified Arabinonucleic Acids: Synthesis, Biophysical and Antisense Properties Pontarelli A; Wilds CJ; 36857293
CHEMBIOCHEM
5 Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides Pontarelli A; Liu JT; Oh JK; Wilds CJ; 36840706
CHEMBIOCHEM
6 Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts Caspari OD; Garrido C; Law CO; Choquet Y; Wollman FA; Lafontaine I; 36733255
BIOLOGY
7 Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H Pontarelli A; Wilds CJ; 35452799
CHEMBIOCHEM
8 Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides Holgersen EM; Gandhi S; Zhou Y; Kim J; Vaz B; Bogojeski J; Bugno M; Shalev Z; Cheung-Ong K; Gonçalves J; O' Hara M; Kron K; Verby M; Sun M; Kakaradov B; Delong A; Merico D; Deshwar AG; 34388351
ENCS
9 Duplicated antagonistic EPF peptides optimize grass stomatal initiation Jangra R; Brunetti SC; Wang X; Kaushik P; Gulick PJ; Foroud NA; Wang S; Lee JS; 34328169
BIOLOGY
10 Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex Olajide OJ; Chapman CA; 34144329
PSYCHOLOGY
11 Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I; 34064722
BIOLOGY
12 Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications Liczner C; Duke K; Juneau G; Egli M; Wilds CJ; 33981365
CHEMBIOCHEM
13 Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. Copp W, Pontarelli A, Wilds CJ 33506614
CHEMBIOCHEM
14 Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts Behmand B; Noronha AM; Wilds CJ; Marignier JL; Mostafavi M; Wagner JR; Hunting DJ; Sanche L; 32211848
CHEMBIOCHEM
15 Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans. Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J 32075883
BIOLOGY
16 Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics. Millet-Boureima C, Chingle R, Lubell WD, Gamberi C 31635379
BIOLOGY
17 Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Janssen P, de Leede L, Meyer JJ, Everaerd W, Frijlink HW, Koppeschaar HP, Olivier B, Pfaus JG 30016917
CSBN
18 O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage. O'Flaherty DK, Wilds CJ 26692563
CHEMISTRY
19 TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins. Sacher M, Shahrzad N, Kamel H, Milev MP 30152084
BIOLOGY
20 Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae). Bhagavathula N, Meedidoddi V, Bourque S, Vimaladevi R, Kesavakurup S, Selvadurai D, Shrivastava S, Krishnappa C 28346717
PERFORM

 

Title:O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.
Authors:O'Flaherty DK,  Wilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/26692563?dopt=Abstract
DOI:10.1002/asia.201501253
Publication:Chemistry, an Asian journal
Keywords:DNA damage;  DNA repair;  O6-alkylguanine DNA alkyltransferase;  intrastrand cross-link;  oligonucleotides; 
PMID:26692563 Category:Chem Asian J Date Added:2019-06-20
Dept Affiliation: CHEMISTRY
1 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada.
2 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada. Chris.Wilds@concordia.ca.

Description:

O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.

Chem Asian J. 2016 Feb 18;11(4):576-83

Authors: O'Flaherty DK, Wilds CJ

Abstract

Oligonucleotides containing an alkylene intrastrand cross-link (IaCL) between the O(6) -atoms of two consecutive 2'-deoxyguanosines (dG) were prepared by solid-phase synthesis. UV thermal denaturation studies of duplexes containing butylene and heptylene IaCL revealed a 20?°C reduction in stability compared to the unmodified duplexes. Circular dichroism profiles of these IaCL DNA duplexes exhibited signatures consistent with B-form DNA. Human O(6) -alkylguanine DNA alkyltransferase (hAGT) was capable of repairing both IaCL containing duplexes with slightly greater efficiency towards the heptylene analog. Interestingly, repair efficiencies of hAGT towards these IaCL were lower compared to O(6) -alkylene linked IaCL lacking the 5'-3'-phosphodiester linkage between the connected 2'-deoxyguanosine residues. These results demonstrate that the proficiency of hAGT activity towards IaCL at the O(6) -atom of dG is influenced by the backbone phosphodiester linkage between the cross-linked residues.

PMID: 26692563 [PubMed - indexed for MEDLINE]




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