PERFORM Publications

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Title		Authors	PubMed ID
1	Biological sex and bilingualism: Its impact on risk and resilience for dementia	Calvo N; Phillips N; Bialystok E; Einstein G;	41573422 PSYCHOLOGY
2	Evolution from the physical process-based approaches to machine learning approaches to predicting urban floods: a literature review	Md Shike Bin Mazid Anik	40692624 ENCS
3	Ten new insights in climate science 2024	Schaeffer R; Schipper ELF; Ospina D; Mirazo P; Alencar A; Anvari M; Artaxo P; Biresselioglu ME; Blome T; Boeckmann M; Brink E; Broadgate W; Bustamante M; Cai W; Canadell JG; Cardinale R; Chidichimo MP; Ditlevsen P; Eicker U; Feron S; Fikru MG; Fuss S; Gaye AT; Gustafsson Ö; Harring N; He C; Hebden S; Heilemann A; Hirota M; Janardhanan N; Juhola S; Jung TY; Kejun J; Kilki? S; Kumarasinghe N; Lapola D; Lee JY; Levis C; Lusambili A; Maasakkers JD; MacIntosh C; Mahmood J; Mankin JS; Marchegiani P; Martin M; Muk	40546753 PHYSICS
4	Resilience, Stress, and Mental Health Among University Students: A Test of the Resilience Portfolio Model	Fang S; Barker E; Arasaratnam G; Lane V; Rabinovich D; Panaccio A; O' Connor RM; Nguyen CT; Doucerain MM;	39641152 PSYCHOLOGY
5	Vulnerability and narrative in later life	de Medeiros K; Ermoshkina P;	38761242 SOCANTH
6	Insights on the COVID-19 pandemic: Youth engagement through photovoice	Pickering CJ; Al-Baldawi Z; McVean L; Adan M; Amany RA; Al-Baldawi Z; Baker L; O' Sullivan T;	36373152 PSYCHOLOGY
7	We're building it up to burn it down: fire occurrence and fire-related climatic patterns in Brazilian biomes	Diele Viegas LM; Sales L; Hipólito J; Amorim C; Johnson de Pereira E; Ferreira P; Folta C; Ferrante L; Fearnside P; Mendes Malhado AC; Frederico Duarte Rocha C; M Vale M;	36312759 BIOLOGY
8	The Association Between Dietary Pattern Adherence, Cognitive Stimulating Lifestyle, and Cognitive Function Among Older Adults From the Quebec Longitudinal Study on Nutrition and Successful Aging	Parrott MD; Carmichael PH; Laurin D; Greenwood CE; Anderson ND; Ferland G; Gaudreau P; Belleville S; Morais JA; Kergoat MJ; Fiocco AJ;	33063101 PERFORM
9	Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.	Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L	28774705 PSYCHOLOGY

Title:	Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.
Authors:	Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28774705?dopt=Abstract
DOI:	10.1016/j.euroneuro.2017.07.005
Publication:	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Keywords:	DNA methylation; Frontal cortex; Functional magnetic resonance imaging; Resilience; Serotonin transporter;
PMID:	28774705	Category:	Eur Neuropsychopharmacol	Date Added:	2019-06-20
Dept Affiliation:	PSYCHOLOGY 1 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada. 2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. 3 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. 4 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada. 5 Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada. 6 Department of Psychiatry, McGill University, Montreal, Canada. 7 CHU Sainte-Justine Research Centre, Montreal, Canada; School of Psychoeducation, University of Montreal, Montreal, Canada. 8 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland. 9 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041

Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Abstract

Early adversity can influence gene expression via epigenetic mechanisms, including DNA methylation. Peripheral tissues are essential in psychiatric epigenetics, as methylation generally cannot be assessed in the living human brain. Several magnetic resonance imaging (MRI) studies show associations of peripheral serotonin transporter gene (SLC6A4) methylation with function and/or structure of frontal-limbic circuits and brain's resting-state. Commonly used samples are derived from blood, saliva or buccal cells. However, little is known regarding which peripheral tissue is most strongly associated with human brain processes. The aim of the current study was to compare the extent of the association between peripheral SLC6A4 promoter methylation and frontal-limbic function, structure and resting-state in healthy individuals across peripheral tissues. Forty healthy prospectively-followed adults underwent anatomical, resting-state and functional MRI. Saliva-, blood- and buccal-derived DNA methylation was assessed by pyrosequencing. Blood-derived SLC6A4 methylation was positively associated with superior frontal gray matter (GM) volume and with right lateral parietal area (RLP)-frontal pole regional resting-state functional connectivity (rsFC). Saliva-derived SLC6A4 methylation was positively associated with superior frontal GM volume. Buccal-derived SLC6A4 methylation was positively associated with superior and inferior frontal and anterior cingulate cortical (ACC) GM volumes, and with RLP-ACC, frontal pole and medial prefrontal regional rsFC. Current results confirmed the relevance of peripheral methylation for frontal-limbic processes in humans. Buccal cells may be the most sensitive cell type when studying SLC6A4 promoter methylation and its associated risk for neural vulnerability and resilience for psychopathologies in which serotonin is implicated. These data should be further validated in clinical populations.

PMID: 28774705 [PubMed - indexed for MEDLINE]

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