Keyword search (4,163 papers available)

"Inhibition" Keyword-tagged Publications:

Title Authors PubMed ID
1 The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats Borges C; Darecka A; Mainville-Berthiaume A; Ah-Yen E; Darvishmolla M; Courtemanche R; Shalev U; 41506524
HKAP
2 In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS; 40516590
CHEMBIOCHEM
3 Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat Germé K; Persad D; Petit-Robinson J; Amir S; Pfaus JG; 40232387
PSYCHOLOGY
4 Acute ethanol disrupts conditioned inhibition in the male rat Germé K; Pfaus JG; 38822097
CSBN
5 OFC neurons do not represent the negative value of a conditioned inhibitor Esber GR; Usypchuk A; Saini S; Deroche M; Iordanova MD; Schoenbaum G; 38042330
CONCORDIA
6 Inhibited and Retarded Behavior by Ca2+ and Ca2+/OD Loading Rate on Ureolytic Bacteria in MICP Process Fukue M; Lechowicz Z; Fujimori Y; Emori K; Mulligan CN; 37176240
ENCS
7 Coping and Conformity Motives Mediate the Joint Effects of the Behavioral Inhibition and Approach Systems on Alcohol Problems in Young Adults Morris V; Keough MT; Stewart SH; O' Connor RM; 36943012
PSYCHOLOGY
8 How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism Pellegrino G; Hedrich T; Sziklas V; Lina JM; Grova C; Kobayashi E; 34002916
PERFORM
9 Effect of Fe2+ ions on gypsum precipitation during bulk crystallization of reverse osmosis concentrates. Melliti E, Touati K, Van der Bruggen B, Elfil H 32814139
ENCS
10 Processing High-Solid and High-Ammonia Rich Manures in a Two-Stage (Liquid-Solid) Low-Temperature Anaerobic Digestion Process: Start-Up and Operating Strategies. Mahato P, Goyette B, Rahaman MS, Rajagopal R 32722477
ENCS
11 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
12 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
13 Poor inhibition of personally-relevant facial expressions of sadness and anger predicts an elevated cortisol response following awakening six months later. Wong SF, Trespalacios F, Ellenbogen MA 32057777
PSYCHOLOGY
14 Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase from Yersinia pestis. Bastos Lda C, de Souza FR, Guimarães AP, Sirouspour M, Cuya Guizado TR, Forgione P, Ramalho TC, França TC 26494420
CHEMISTRY
15 Directed evolution of a fungal β-glucosidase in Saccharomyces cerevisiae. Larue K, Melgar M, Martin VJ 26949413
CSFG

 

Title:Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.
Authors:Lafferty CK,  Yang AK,  Mendoza JA,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/32187545?dopt=Abstract
DOI:10.1016/j.celrep.2020.02.095
Publication:Cell reports
Keywords:basolateral amygdala;  behavioral inhibition;  direct pathway;  fiber photometry;  indirect pathway;  nucleus accumbens;  optogenetics;  paraventricular nucleus of the thalamus;  place preference;  self-stimulation; 
PMID:32187545 Category:Cell Rep Date Added:2020-03-19
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
3 Department of Psychology, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3

Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Abstract

The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.

PMID: 32187545 [PubMed - as supplied by publisher]




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