Keyword search (4,163 papers available)

"DNA damage" Keyword-tagged Publications:

Title Authors PubMed ID
1 Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P; 39920830
BIOLOGY
2 Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J; 35886903
BIOLOGY
3 Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study. Azab B, Alassaf A, Abu-Humdan A, Dardas Z, Almousa H, Alsalem M, Khabour O, Hammad H, Saleh T, Awidi A 32206030
BIOLOGY
4 O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage. O'Flaherty DK, Wilds CJ 26692563
CHEMISTRY

 

Title:Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study.
Authors:Azab B,  Alassaf A,  Abu-Humdan A,  Dardas Z,  Almousa H,  Alsalem M,  Khabour O,  Hammad H,  Saleh T,  Awidi A
Link:https://www.ncbi.nlm.nih.gov/pubmed/32206030?dopt=Abstract
DOI:10.2478/intox-2019-0011
Publication:Interdisciplinary toxicology
Keywords:DNA damage;  carboplatin;  chromosomal aberrations;  cisplatin;  sister-chromatid exchange; 
PMID:32206030 Category:Interdiscip Toxicol Date Added:2020-03-25
Dept Affiliation: BIOLOGY
1 School of Medicine, The University of Jordan, Amman, Jordan.
2 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences , Jordan University of Science and Technology, Irbid, Jordan.
3 Department of Biology, School of Science, Concordia University, Montreal, Canada.
4 Department of Biology, School of Science, University of Jordan, Amman, Jordan.
5 Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.

Description:

Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study.

Interdiscip Toxicol. 2019 Oct;12(2):93-97

Authors: Azab B, Alassaf A, Abu-Humdan A, Dardas Z, Almousa H, Alsalem M, Khabour O, Hammad H, Saleh T, Awidi A

Abstract

Cisplatin and carboplatin are integral parts of many antineoplastic management regimens. Both platinum analogues are potent DNA alkylating agents that robustly induce genomic instability and promote apoptosis in tumor cells. Although the mechanism of action of both drugs is similar, cisplatin appears to be more cytotoxic. In this study, the genotoxic potential of cisplatin and carboplatin was compared using chromosomal aberrations (CAs) and sister-chromatid exchange (SCE) assays in cultured human lymphocytes. Results showed that cisplatin and carboplatin induced a significant increase in CAs and SCEs compared to the control group (p<0.01). Levels of induced CAs were similar in both drugs; however, the magnitude of SCEs induced by cisplatin was significantly higher than that induced by carboplatin (p<0.01). With respect to the mitotic and proliferative indices, both cisplatin and carboplatin significantly decreased mitotic index (p<0.01) without affecting the proliferative index (p>0.05). In conclusion, cisplatin was found to be more genotoxic than carboplatin in the SCE assay in cultured human lymphocytes, and that might explain the higher cytotoxicity of cisplatin.

PMID: 32206030 [PubMed]




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