Keyword search (4,164 papers available)

"DNA damage" Keyword-tagged Publications:

Title Authors PubMed ID
1 Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P; 39920830
BIOLOGY
2 Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J; 35886903
BIOLOGY
3 Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study. Azab B, Alassaf A, Abu-Humdan A, Dardas Z, Almousa H, Alsalem M, Khabour O, Hammad H, Saleh T, Awidi A 32206030
BIOLOGY
4 O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage. O'Flaherty DK, Wilds CJ 26692563
CHEMISTRY

 

Title:O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.
Authors:O'Flaherty DK,  Wilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/26692563?dopt=Abstract
DOI:10.1002/asia.201501253
Publication:Chemistry, an Asian journal
Keywords:DNA damage;  DNA repair;  O6-alkylguanine DNA alkyltransferase;  intrastrand cross-link;  oligonucleotides; 
PMID:26692563 Category:Chem Asian J Date Added:2019-06-20
Dept Affiliation: CHEMISTRY
1 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada.
2 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada. Chris.Wilds@concordia.ca.

Description:

O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.

Chem Asian J. 2016 Feb 18;11(4):576-83

Authors: O'Flaherty DK, Wilds CJ

Abstract

Oligonucleotides containing an alkylene intrastrand cross-link (IaCL) between the O(6) -atoms of two consecutive 2'-deoxyguanosines (dG) were prepared by solid-phase synthesis. UV thermal denaturation studies of duplexes containing butylene and heptylene IaCL revealed a 20?°C reduction in stability compared to the unmodified duplexes. Circular dichroism profiles of these IaCL DNA duplexes exhibited signatures consistent with B-form DNA. Human O(6) -alkylguanine DNA alkyltransferase (hAGT) was capable of repairing both IaCL containing duplexes with slightly greater efficiency towards the heptylene analog. Interestingly, repair efficiencies of hAGT towards these IaCL were lower compared to O(6) -alkylene linked IaCL lacking the 5'-3'-phosphodiester linkage between the connected 2'-deoxyguanosine residues. These results demonstrate that the proficiency of hAGT activity towards IaCL at the O(6) -atom of dG is influenced by the backbone phosphodiester linkage between the cross-linked residues.

PMID: 26692563 [PubMed - indexed for MEDLINE]




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