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PubMed Publications| Keyword search (4,163 papers available) |  |
"Aspergillus" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of two pH-dependent permeases | Sgro M; Reid ID; Arentshorst M; Ram AFJ; Tsang A; | 40853219 GENOMICS |
| 2 | Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger | Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Sándor E; Kovács B; Geoffrion N; Tsang A; Kubicek CP; Karaffa L; | 39377610 CSFG |
| 3 | Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger | Sgro M; Chow N; Olyaei F; Arentshorst M; Geoffrion N; Ram AFJ; Powlowski J; Tsang A; | 37399977 BIOLOGY |
| 4 | Bioreactor as the root cause of the "manganese effect" during Aspergillus niger citric acid fermentations | Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Németh Z; Sándor E; Kovács B; Fábián I; Kubicek CP; Tsang A; Karaffa L; | 35992333 CSFG |
| 5 | Lignocellulolytic enzymes from Aspergillus allahabadii for efficient bioconversion of rice straw into fermentable sugars and biogas | Sharma G; Kaur B; Raheja Y; Agrawal D; Basotra N; Di Falco M; Tsang A; Singh Chadha B; | 35753566 CSFG |
| 6 | The chimeric GaaR-XlnR transcription factor induces pectinolytic activities in the presence of D-xylose in Aspergillus niger | Kun RS; Garrigues S; Di Falco M; Tsang A; de Vries RP; | 34236481 CSFG |
| 7 | Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics | Evdokias G; Semper C; Mora-Ochomogo M; Di Falco M; Nguyen TTM; Savchenko A; Tsang A; Benoit-Gelber I; | 34064722 BIOLOGY |
| 8 | Genetic Characterization of Mutations Related to Conidiophore Stalk Length Development in Aspergillus niger Laboratory Strain N402 | Demirci E; Arentshorst M; Yilmaz B; Swinkels A; Reid ID; Visser J; Tsang A; Ram AFJ; | 33959152 CSFG |
| 9 | Biosynthesis of Alkylcitric Acids in Aspergillus niger Involves Both Co-localized and Unlinked Genes. | Palys S, Pham TTM, Tsang A | 32695080 CSFG |
| 10 | Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. | Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lagrou K, Marcet-Houben M, Gabaldón T, McDonnell E, Reid I, Tsang A, Oakley BR, Loures FV, Almeida F, Huttenlocher A, Keller NP, Ries LNA, Goldman GH | 32269156 CSFG |
| 11 | The effects of external Mn2+ concentration on hyphal morphology and citric acid production are mediated primarily by the NRAMP-family transporter DmtA in Aspergillus niger. | Fejes B, Ouedraogo JP, Fekete E, Sándor E, Flipphi M, Soós Á, Molnár ÁP, Kovács B, Kubicek CP, Tsang A, Karaffa L | 32000778 CSFG |
| 12 | Evolutionary adaptation of Aspergillus niger for increased ferulic acid tolerance. | Lubbers RJM, Liwanag AJ, Peng M, Dilokpimol A, Benoit-Gelber I, de Vries RP | 31674709 CSFG |
| 13 | Four Aromatic Intradiol Ring Cleavage Dioxygenases from Aspergillus niger. | Semana P, Powlowski J | 31540981 CHEMISTRY |
| 14 | Closely related fungi employ diverse enzymatic strategies to degrade plant biomass. | Benoit I, Culleton H, Zhou M, DiFalco M, Aguilar-Osorio G, Battaglia E, Bouzid O, Brouwer CPJM, El-Bushari HBO, Coutinho PM, Gruben BS, Hildén KS, Houbraken J, Barboza LAJ, Levasseur A, Majoor E, Mäkelä MR, Narang HM, Trejo-Aguilar B, van den Brink J, vanKuyk PA, Wiebenga A, McKie V, McCleary B, Tsang A, Henrissat B, de Vries RP | 26236396 CSFG |
| 15 | Expression-based clustering of CAZyme-encoding genes of Aspergillus niger. | Gruben BS, Mäkelä MR, Kowalczyk JE, Zhou M, Benoit-Gelber I, De Vries RP | 29169319 CSFG |
| 16 | W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger. | Alazi E, Niu J, Otto SB, Arentshorst M, Pham TTM, Tsang A, Ram AFJ | 30298571 CSFG |
| 17 | The gold-standard genome of Aspergillus niger NRRL 3 enables a detailed view of the diversity of sugar catabolism in fungi. | Aguilar-Pontes MV, Brandl J, McDonnell E, Strasser K, Nguyen TTM, Riley R, Mondo S, Salamov A, Nybo JL, Vesth TC, Grigoriev IV, Andersen MR, Tsang A, de Vries RP | 30425417 CSFG |
| 18 | Genomic and exoproteomic diversity in plant biomass degradation approaches among Aspergilli | Mäkelä MR; DiFalco M; McDonnell E; Nguyen TTM; Wiebenga A; Hildén K; Peng M; Grigoriev IV; Tsang A; de Vries RP; | 30487660 CSFG |
| 19 | The presence of trace components significantly broadens the molecular response of Aspergillus niger to guar gum. | Coconi Linares N, Di Falco M, Benoit-Gelber I, Gruben BS, Peng M, Tsang A, Mäkelä MR, de Vries RP | 30797054 CSFG |
| Title: | Bioreactor as the root cause of the "manganese effect" during Aspergillus niger citric acid fermentations | ||||
| Authors: | Fekete E, Bíró V, Márton A, Bakondi-Kovács I, Németh Z, Sándor E, Kovács B, Fábián I, Kubicek CP, Tsang A, Karaffa L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35992333/ | ||||
| DOI: | 10.3389/fbioe.2022.935902 | ||||
| Publication: | Frontiers in bioengineering and biotechnology | ||||
| Keywords: | Aspergillus niger; citric acid; fungal morphology; manganese ions; metal ions leaching; stainless steel; | ||||
| PMID: | 35992333 | Category: | Date Added: | 2022-08-22 | |
| Dept Affiliation: |
CSFG
1 Department of Biochemical Engineering, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary. 2 Juhász-Nagy Pál Doctoral School of Biology and Environmental Sciences, University of Debrecen, Debrecen, Hungary. 3 Institute of Food Science, Faculty of Agricultural and Food Science and Environmental Management, University of Debrecen, Debrecen, Hungary. 4 Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary. 5 MTA-DE Redox and Homogeneous Catalytic Reaction Mechanism Research Group, Debrecen, Hungary. 6 Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria. 7 Centre for Structural and Functional Genomics, Concordia University, Montreal, QC, Canada. 8 Institute of Metagenomics, University of Debrecen, Debrecen, Hungary. |
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Description: |
High-yield citric acid production by the filamentous Ascomycete fungus Aspergillus niger requires a combination of extreme nutritional conditions, of which maintaining a low manganese (II) ion concentration (<5 µg L-1) is a key feature. Technical-scale production of citric acid predominantly uses stainless-steel tank fermenters, but glass bioreactors used for strain improvement and manufacturing process development also contain stainless steel components, in which manganese is an essential alloying element. We show here that during citric acid fermentations manganese (II) ions were leaching from the bioreactor into the growth media, resulting in altered fungal physiology and morphology, and significant reduction of citric acid yields. The leaching of manganese (II) ions was dependent on the fermentation time, the acidity of the culture broth and the sterilization protocol applied. Manganese (II) ion leaching was partially mitigated by electrochemical polishing of stainless steel components of the bioreactor. High concentrations of manganese (II) ions during early cultivation led to a reduction in citric acid yield. However, the effect of manganese (II) ions on the reduction of citric acid yield diminished towards the second half of the fermentation. Since maintaining low concentrations of manganese (II) ions is costly, the results of this study can potentially be used to modify protocols to reduce the cost of citric acid production. |
