PERFORM Publications

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Title		Authors	PubMed ID
1	Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.	Charlton DE, Nikjoo H, Humm JL	2569005 PHYSICS
2	Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.	Charlton DE, Allen BJ	7903342 PHYSICS
3	Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.	Charlton DE, Turner MS	8609458 PHYSICS
4	Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.	Charlton DE, Utteridge TD, Beddoe AH	8648246 PHYSICS
5	Radiation effects in spheroids of cells exposed to alpha emitters.	Charlton DE	11098858 PHYSICS

Title:	Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.
Authors:	Charlton DE, Allen BJ
Link:	https://www.ncbi.nlm.nih.gov/pubmed/7903342?dopt=Abstract
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PMID:	7903342	Category:	Int J Radiat Biol	Date Added:	2019-06-04
Dept Affiliation:	PHYSICS

Description:

Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Int J Radiat Biol. 1993 Dec;64(6):739-47

Authors: Charlton DE, Allen BJ

Abstract

The Monte Carlo technique is used to examine the passage of ions from the (n, p) reaction in nitrogen and the (n, alpha) reaction in 10B through the nuclei of endothelial capillary wall cells of normal white matter. Contributions to the dose from different regions are evaluated, as is the distribution of doses to the nuclei for mean doses from 1 to 100 Gy. Calculation of mean dose to the nuclei is generalized for any neutron fluence and element concentration. The dose-averaged LETs for both reactions are found giving (for the particular conditions of the calculation); 60 keV/microns for the (n, p) reaction and 216 keV/micron for the (n, alpha) reaction in boron limited to the lumen, and 224 keV/micron for a uniform distribution of boron. From a consideration of 'minimal survival' and hit and dose distributions, evidence is presented which suggests that the RBE for the (n, alpha) reaction depends upon the distribution of the boron in the tissue, with the uniform distribution being less effective at cell killing than the boron restricted to the lumen for the same mean dose to the cell nuclei.

PMID: 7903342 [PubMed - indexed for MEDLINE]

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