Keyword search (4,164 papers available)

"Int J Radiat Biol" Category Publications:

Title Authors PubMed ID
1 Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles. Charlton DE, Nikjoo H, Humm JL 2569005
PHYSICS
2 Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy. Charlton DE, Allen BJ 7903342
PHYSICS
3 Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation. Charlton DE, Turner MS 8609458
PHYSICS
4 Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue. Charlton DE, Utteridge TD, Beddoe AH 8648246
PHYSICS
5 Radiation effects in spheroids of cells exposed to alpha emitters. Charlton DE 11098858
PHYSICS

 

Title:Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.
Authors:Charlton DEUtteridge TDBeddoe AH
Link:https://www.ncbi.nlm.nih.gov/pubmed/8648246?dopt=Abstract
Publication:
Keywords:
PMID:8648246 Category:Int J Radiat Biol Date Added:2019-06-04
Dept Affiliation: PHYSICS

Description:

Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Int J Radiat Biol. 1996 May;69(5):585-92

Authors: Charlton DE, Utteridge TD, Beddoe AH

Abstract

The Monte Carlo method is used to model fat cells and the nuclei of stem cells in haemopoietic tissue where 222Rn is dissolved in different amounts in the fat and tissue. Calculations are performed for fat cells of diameters 50 and 100 microns and for stem cell nuclei of 8 and 16 microns diameters for various fractions of fat filling the volume. Average doses (and their distributions) to stem cell nuclei from single passages of alpha particles are presented. In addition to dose, the relationship between LET and dose is obtained, illustrating the importance of 'stoppers' in the calculations. The annual average dose equivalent for a concentration of 1 Bq/m3 in air agrees well with other authors at 12 mu Sv/year. The method also allows the calculation of the fraction of stem cell nuclei hit annually. Here for 1 Bq/m3, stem cell nuclei of diameter 8 microns and 100% fat filing 15 x 10(-7) of the stem cell nuclei are hit.

PMID: 8648246 [PubMed - indexed for MEDLINE]





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