Keyword search (4,163 papers available)

"Horm Behav" Category Publications:

Title Authors PubMed ID
1 Fos expression is increased in oxytocin neurons of female rats with a sexually conditioned mate preference for an individual male rat. Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG 31647923
PSYCHOLOGY
2 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
3 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
4 Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner. Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A 29080670
CSBN
5 Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol. Georgescu M, Afonso VM, Graham MD, Pfaus JG 24333845
PSYCHOLOGY
6 Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation. Jones SL, Pfaus JG 25251978
PSYCHOLOGY
7 The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues. Jones SL, Antonie RA, Pfaus JG 25960082
PSYCHOLOGY
8 Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood. Jones SL, Cordeaux E, Germé K, Pfaus JG 26163151
PSYCHOLOGY
9 RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse. Jones SL, Gardner Gregory J, Pfaus JG 26210062
PSYCHOLOGY
10 Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young. Jonas W, Woodside B 26232032
CSBN
11 Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat. Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG 26278846
PSYCHOLOGY
12 Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat. Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG 30690029
PSYCHOLOGY

 

Title:High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.
Authors:Madularu D,  Kulkarni P,  Yee JR,  Kenkel WM,  Shams WM,  Ferris CF,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/27154458?dopt=Abstract
DOI:10.1016/j.yhbeh.2016.04.007
Publication:Hormones and behavior
Keywords:Antipsychotic;  Dopamine;  Estradiol;  Ovariectomy;  Schizophrenia;  fMRI; 
PMID:27154458 Category:Horm Behav Date Added:2019-06-20
Dept Affiliation: CSBN
1 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6. Electronic address: dan.madularu@gmail.com.
2 Northeastern University, Department of Psychology, Center for Translational Neuroimaging, 360 Huntington Ave, Boston, MA, USA, 02115.
3 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6.

Description:

High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Horm Behav. 2016 06;82:56-63

Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Abstract

The ovarian hormone estrogen has been implicated in schizophrenia symptomatology. Low levels of estrogen are associated with an increase in symptom severity, while exogenous estrogen increases the efficacy of antipsychotic medication, pointing at a possible interaction between estrogen and the dopaminergic system. The aim of this study is to further investigate this interaction in an animal model of some aspects of schizophrenia using awake functional magnetic resonance imaging. Animals receiving 17ß-estradiol and haloperidol were scanned and BOLD activity was assessed in response to amphetamine. High 17ß-estradiol replacement and chronic haloperidol treatment showed increased BOLD activity in regions of interest and neural networks associated with schizophrenia (hippocampal formations, habenula, amygdala, hypothalamus etc.), compared with low, or no 17ß-estradiol. These data show that chronic haloperidol treatment has a sensitizing effect, possibly on the dopaminergic system, and this effect is dependent on hormonal status, with high 17ß-estradiol showing the greatest BOLD increase. Furthermore, these experiments further support the use of imaging techniques in studying schizophrenia, as modeled in the rat, but can be extended to addiction and other disorders.

PMID: 27154458 [PubMed - indexed for MEDLINE]




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