PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Fos expression is increased in oxytocin neurons of female rats with a sexually conditioned mate preference for an individual male rat.	Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG	31647923 PSYCHOLOGY
2	High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.	Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG	27154458 CSBN
3	Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.	Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG	28062232 PSYCHOLOGY
4	Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.	Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A	29080670 CSBN
5	Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol.	Georgescu M, Afonso VM, Graham MD, Pfaus JG	24333845 PSYCHOLOGY
6	Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.	Jones SL, Pfaus JG	25251978 PSYCHOLOGY
7	The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.	Jones SL, Antonie RA, Pfaus JG	25960082 PSYCHOLOGY
8	Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.	Jones SL, Cordeaux E, Germé K, Pfaus JG	26163151 PSYCHOLOGY
9	RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.	Jones SL, Gardner Gregory J, Pfaus JG	26210062 PSYCHOLOGY
10	Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young.	Jonas W, Woodside B	26232032 CSBN
11	Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.	Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG	26278846 PSYCHOLOGY
12	Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.	Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG	30690029 PSYCHOLOGY

Title:	Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.
Authors:	Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A
Link:	https://www.ncbi.nlm.nih.gov/pubmed/29080670?dopt=Abstract
DOI:	10.1016/j.yhbeh.2017.10.012
Publication:	Hormones and behavior
Keywords:	Anticipation; Ghrelin; Ghrelin receptor antagonist; Ghrelin receptor knock out rats; Intracranial drug delivery; MPOA; Sex motivation; VTA;
PMID:	29080670	Category:	Horm Behav	Date Added:	2019-06-20
Dept Affiliation:	CSBN 1 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada. 2 Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. 3 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada; Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. 4 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada. Electronic address: alfonso_abizaid@carleton.ca.

Description:

Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Horm Behav. 2018 01;97:56-66

Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Abstract

Ghrelin, a hormone produced primarily by the stomach, has been associated with motivational processes that include reward-seeking behaviors. In male laboratory mice, elevation of ghrelin levels enhances some aspects of sexual motivation and behavior, whereas in other experiments with male mice, rats, and other species, ghrelin treatment or food deprivation decreases sexual motivation and/or behavior. The present tested the hypothesis that stimulation of ghrelin receptors in different brain regions have opposite effects on male sexual motivation and behavior. To do this we examined appetitive and consummatory sex behaviors of male rats with a truncated ghrelin receptor (FHH-GHSRm1/Mcwi), and that of their WT (FHH) littermates. We also examined the effects of ghrelin or the ghrelin antagonist D-Lys-GHRP6 delivered into the VTA or the MPOA on appetitive and consummatory sex behaviors in male Long Evans rats. Results demonstrate that rats with a truncated ghrelin receptor, or rats that are food deprived, show deficits in anticipatory sex. Furthermore, although ghrelin does not further stimulate sex anticipation in rats when infused into the VTA, intra-VTA infusions of D-Lys-GHRP6 into the VTA further decreases in sex anticipation in food deprived rats. In contrast, ghrelin delivery into the mPOA decreased sex anticipation compared to saline or D-Lys-GHRP6 infused rats. Overall, these data suggest that ghrelin receptor signalling is important for full expression of appetitive sex behaviors. Within the VTA, ghrelin may act to enhance sex motivation, while acting on the mPOA to decrease sex motivation and promote foraging.

PMID: 29080670 [PubMed - indexed for MEDLINE]

BookR: School of Health Core Facilities Booking

"Horm Behav" Category Publications:

Search Publications

No results