Keyword search (4,164 papers available)

"Son S" Authored Publications:

Title Authors PubMed ID
1 Regioselective Stepwise Synthesis of Unsymmetrical 1,2,5-Triarylpyrroles via Palladium-Catalyzed Decarboxylative Cross-Coupling and C-H Arylation Buonomano C; Patterson S; Ngou JS; Messina C; Taylor S; Bilodeau F; Forgione P; 41900086
CHEMBIOCHEM
2 Clinical Manifestations Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; 41447475
CONCORDIA
3 Public Health Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M; 41435121
CONCORDIA
4 Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; 40966614
SOH
5 Sequencing of a Dairy Isolate Unlocks em Kluyveromyces marxianus /em as a Host for Lactose Valorization Thornbury M; Knoops A; Summerby-Murray I; Dhaliwal J; Johnson S; Utomo JC; Joshi J; Narcross L; Remondetto G; Pouliot M; Whiteway M; Martin VJJ; 40629255
BIOLOGY
6 Self-Ambivalence Is Indirectly Associated With Obsessive-Compulsive and Eating Disorder Symptoms Through Different Feared Self-Themes Wilson S; Mesli N; Mehak A; Racine SE; 40227164
PSYCHOLOGY
7 Expanding a Behavioral View on Digital Health Access: Drivers and Strategies to Promote Equity Kepper MM; Fowler LA; Kusters IS; Davis JW; Baqer M; Sagui-Henson S; Xiao Y; Tarfa A; Yi JC; Gibson B; Heron KE; Alberts NM; Burgermaster M; Njie-Carr VP; Klesges LM; 39088246
PSYCHOLOGY
8 Feasibility and acceptability of an adapted peer-based walking intervention for adults with moderate-to-severe traumatic brain injury Quilico EL; Wilkinson S; Duncan LR; Sweet SN; Alarie C; Bédard E; Gheta I; Brodeur CL; Colantonio A; Swaine BR; 39051571
CONCORDIA
9 Criminal Code reform of HIV non-disclosure is urgently needed: Social science perspectives on the harms of HIV criminalization in Canada Hastings C; French M; McClelland A; Mykhalovskiy E; Adam B; Bisaillon L; Bogosavljevic K; Gagnon M; Greene S; Guta A; Hindmarch S; Kaida A; Kilty J; Massaquoi N; Namaste V; O' Byrne P; Orsini M; Patterson S; Sanders C; Symington A; Wilson C; 38087186
PSYCHOLOGY
10 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT; 37888959
BIOLOGY
11 Spatial and Temporal Availability of Cloud-free Optical Observations in the Tropics to Monitor Deforestation Flores-Anderson AI; Cardille J; Azad K; Cherrington E; Zhang Y; Wilson S; 37607919
ENCS
12 Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; 37471089
PERFORM
13 COVID-19's impact on a community-based physical activity program for adults with moderate-to-severe TBI Quilico EL; Wilkinson S; Bédard E; Duncan LR; Sweet SN; Swaine BR; Colantonio A; 37184357
AHSC
14 Exploring a peer-based physical activity program in the community for adults with moderate-to-severe traumatic brain injury Quilico E; Sweet S; Duncan L; Wilkinson S; Bonnell K; Alarie C; Swaine B; Colantonio A; 37157834
AHSC
15 A metagenomic-based study of two sites from the Barbadian reef system Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT; 37009568
BIOLOGY
16 Participatory co-creation of an adapted physical activity program for adults with moderate-to-severe traumatic brain injury Quilico E; Wilkinson S; Duncan L; Sweet S; Bédard E; Trudel E; Colantonio A; Swaine B; 36188895
AHSC
17 A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT; 35972285
BIOLOGY
18 Mutations in TRAPPC12 Manifest in Progressive Childhood Encephalopathy and Golgi Dysfunction. Milev MP, Grout ME, Saint-Dic D, Cheng YH, Glass IA, Hale CJ, Hanna DS, Dorschner MO, Prematilake K, Shaag A, Elpeleg O, Sacher M, Doherty D, Edvardson S 28777934
BIOLOGY
19 Parental Nutrition Knowledge Rather Than Nutrition Label Use Is Associated With Adiposity in Children. Kakinami L, Houle-Johnson S, McGrath JJ 27373860
PERFORM

 

Title:Clinical Manifestations
Authors:Gagnon CMontero-Odasso MZou GSpeechley MRAlmeida QJLiu-Ambrose TMiddleton LECamicioli RBray NWLi KFraser SPieruccini-Faria FBurhan AMBerryman NLussier MSon SShoemaker JKBherer L
Link:https://pubmed.ncbi.nlm.nih.gov/41447475/
DOI:10.1002/alz70857_102937
Publication:Alzheimer s & dementia : the journal of the Alzheimer s Association
Keywords:
PMID:41447475 Category: Date Added:2025-12-25
Dept Affiliation: CONCORDIA
1 Montreal Heart Institute, Montreal, QC, Canada.
2 Schulich School of Medicine & Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada.
3 Parkwood Institute, London, ON, Canada.
4 Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
5 University of Wester Ontario, London, ON, Canada.
6 Wilfrid Laurier University, Waterloo, ON, Canada.
7 Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
8 Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
9 University of British Columbia, Vancouver, BC, Canada.
10 Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
11 Schlegel-UW Research Institute for Aging, Waterloo, ON, Canada.
12 University of Waterloo, Waterloo, ON, Canada.
13 University of Alberta, Edmonton, AB, Canada.
14 University of Western Ontario, London, ON, Canada.
15 Concordia University, Montreal, QC, Canada.
16 University of Ottawa, Ottawa, ON, Canada.
17 Gait and Brain Laboratory, Parkwood Institute, London, ON, Canada.
18 Gait & Brain Lab; Lawson Research Institute; Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada.
19 University of Toronto, Toronto, ON, Canada.
20 Parkwood Institute-Mental Health, Western University, London, ON, Canada.
21 Western University, London, ON, Canada.
22 Ontario Shores Centre for Mental Health Sciences, Whitby, ON, Canada.
23 Université du Québec à Montréal, Montréal, QC, Canada.
24 University of Montreal, Montreal, QC, Canada.
25 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada.
26 Université de Montréal, Montréal, QC, Canada.
27 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada.
28 Montreal Heart Institute, Montréal, QC, Canada.

Description:

Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to greater gains on the ADAS-Cog than an active control condition, and physical exercise alone. Yet not all participants showed the same cognitive gains. To date, little is known about the cognitive characteristics of responders vs non-responders to non-pharmacological interventions.

Objective: To compare baseline cognitive profiles of responders and non-responders to physical exercise training alone or in combination with cognitive training.

Methods: Of the 175 initially randomized individuals with MCI in the SYNERGIC trial, 143 completed the 6-month assessment. Regardless of randomization, participants were identified as responders if the change in ADAS-Cog-13 (T6-T0) was negative, indicating improved performances, and non-responders were determined if change was null or positive, indicating decreased performance. Composite z-scores were calculated from the baseline neuropsychological assessment: Global cognition (MoCA), Language (Boston Naming Test, Semantic Verbal fluency), Memory (MoCA delayed recall subscore), Processing Speed (TMT A, Stroop Naming, Stroop Reading), Working Memory (Digit span forward and backward), and Executive Functions (TMT B, Stroop Inhibition and Switching).

Results: Responders (n = 91; 72yrs, 46% female, ADAS-Cog(T0): 15.81) and non-responders (n = 52; 74.2yrs, 54% female, ADAS-Cog(T0): 15.13) were comparable for sex, baseline ADAS-Cog; a trend was observed for older age in non-responders (p = .062). Overall, at baseline, responders had better global cognition (0.14±0.94 vs -0.23±1.07) and executive function performances than non-responders (0.12±0.77 vs-0.21±0.97), ps < .05, but were otherwise comparable. In the intervention arms, the proportion of responders differed significantly: Combined (75%), Physical alone (61%), Active control (44%), (p < .05). In the Combined group, responders had better global cognition (0.38±0.96 Vs -0.20±0.97) and working memory performances (0.25±0.96 Vs -0.28±0.47). In the Physical Alone group, responders and non-responders performed similarly. In the Active Control group, responders had better processing speed performances (0.22±0.31 vs -0.33±0.79) than non-responders.

Conclusion: Responders and non-responders appear to have different baseline cognitive profiles. These results suggest that cognitive and physical training interventions should be tailored and individualized according to baseline cognitive condition.





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