Keyword search (4,163 papers available)

"Shams WM" Authored Publications:

Title Authors PubMed ID
1 Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA; 35939438
CSBN
2 The priming effect of food persists following blockade of dopamine receptors. Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG 31350860
CSBN
3 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
4 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
5 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
6 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN
7 Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN; 29757478
MASSSPEC

 

Title:High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.
Authors:Madularu D,  Kulkarni P,  Yee JR,  Kenkel WM,  Shams WM,  Ferris CF,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/27154458?dopt=Abstract
DOI:10.1016/j.yhbeh.2016.04.007
Publication:Hormones and behavior
Keywords:Antipsychotic;  Dopamine;  Estradiol;  Ovariectomy;  Schizophrenia;  fMRI; 
PMID:27154458 Category:Horm Behav Date Added:2019-06-20
Dept Affiliation: CSBN
1 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6. Electronic address: dan.madularu@gmail.com.
2 Northeastern University, Department of Psychology, Center for Translational Neuroimaging, 360 Huntington Ave, Boston, MA, USA, 02115.
3 Concordia University, Department of Psychology, Center for Studies in Behavioural Neurobiology, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6.

Description:

High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Horm Behav. 2016 06;82:56-63

Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Abstract

The ovarian hormone estrogen has been implicated in schizophrenia symptomatology. Low levels of estrogen are associated with an increase in symptom severity, while exogenous estrogen increases the efficacy of antipsychotic medication, pointing at a possible interaction between estrogen and the dopaminergic system. The aim of this study is to further investigate this interaction in an animal model of some aspects of schizophrenia using awake functional magnetic resonance imaging. Animals receiving 17ß-estradiol and haloperidol were scanned and BOLD activity was assessed in response to amphetamine. High 17ß-estradiol replacement and chronic haloperidol treatment showed increased BOLD activity in regions of interest and neural networks associated with schizophrenia (hippocampal formations, habenula, amygdala, hypothalamus etc.), compared with low, or no 17ß-estradiol. These data show that chronic haloperidol treatment has a sensitizing effect, possibly on the dopaminergic system, and this effect is dependent on hormonal status, with high 17ß-estradiol showing the greatest BOLD increase. Furthermore, these experiments further support the use of imaging techniques in studying schizophrenia, as modeled in the rat, but can be extended to addiction and other disorders.

PMID: 27154458 [PubMed - indexed for MEDLINE]




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