Keyword search (4,163 papers available)

"Shams WM" Authored Publications:

Title Authors PubMed ID
1 Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA; 35939438
CSBN
2 The priming effect of food persists following blockade of dopamine receptors. Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG 31350860
CSBN
3 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
4 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
5 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
6 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN
7 Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN; 29757478
MASSSPEC

 

Title:17β-estradiol locally increases phasic dopamine release in the dorsal striatum.
Authors:Shams WM,  Cossette MP,  Shizgal P,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/29175028?dopt=Abstract
DOI:10.1016/j.neulet.2017.11.039
Publication:Neuroscience letters
Keywords:Estrogens;  Fast-scan cyclic voltammetry; 
PMID:29175028 Category:Neurosci Lett Date Added:2019-06-20
Dept Affiliation: CSBN
1 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: waqqas.shams@gmail.com.
2 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: mpy_cossette@hotmail.com.
3 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: peter.shizgal@concordia.ca.
4 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

17ß-estradiol locally increases phasic dopamine release in the dorsal striatum.

Neurosci Lett. 2018 02 05;665:29-32

Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Abstract

Studies using in vivo microdialysis have shown that 17ß-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of~20-25pg/mL. DA release was evoked every 1min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8pg/µl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.

PMID: 29175028 [PubMed - indexed for MEDLINE]




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