Keyword search (4,163 papers available)

"Oh JK" Authored Publications:

Title Authors PubMed ID
1 Thermo-responsive polysulfobetaine beads crosslinked with biodegradable alginates for controlled release of agricultural pesticide Andrade-Gagnon B; Olszewski C; Bawa KK; Hemraz UD; Oh JK; 41561011
CHEMBIOCHEM
2 Synthesis and Acidic pH-Responsive Disassembly of Dual-Location Shell-Sheddable/Core-Degradable Block Copolymer Nanoassemblies and Their Controlled Drug Delivery Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK; 41524627
CHEMBIOCHEM
3 Luminescent Electro-Spun Nanofibers Crosslinked with Boronic Esters Exhibiting Controlled Release of Carbon Dots for Detection of Wound pHs and Enhanced Antimicrobial Lokuge ND; Casillas-Popova SN; Singh P; Clermont-Paquette A; Skinner CD; Findlay BL; Naccache R; Oh JK; 40920389
BIOLOGY
4 Development of dual acid-visible light-degradable core-crosslinked nanogels with extended conjugate aromatic imines for enhanced drug delivery Bairagi K; Shamekhi M; Tountas I; Letourneau N; Peslherbe GH; Piekny A; Oh JK; 40637173
BIOLOGY
5 Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization Andrade-Gagnon B; Casillas-Popova SN; Oh JK; 40614241
CHEMBIOCHEM
6 Multi-stimuli-responsive degradable boronic ester-crosslinked e-spun nanofiber wound dressings Casillas-Popova SN; Lokuge ND; Singh P; Cirillo A; Thinphang-Nga A; Skinner CD; Vuckovic D; Findlay BL; Oh JK; 40557709
BIOLOGY
7 Research Trends in the Development of Block Copolymer-Based Biosensing Platforms Chung YH; Oh JK; 39590001
CHEMBIOCHEM
8 pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK; 38989606
BIOLOGY
9 Fabrication of thermo-responsive multicore microcapsules using a facile extrusion process Lavertu JD; Bawa KK; Hrapovic S; Fu D; Oh JK; Hemraz UD; 38915334
CHEMBIOCHEM
10 Design, Synthesis, and Acid-Responsive Disassembly of Shell-Sheddable Block Copolymer Labeled with Benzaldehyde Acetal Junction Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK; 38499007
CHEMBIOCHEM
11 Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides Pontarelli A; Liu JT; Oh JK; Wilds CJ; 36840706
CHEMBIOCHEM
12 Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: A potential system for simultaneously targeting bacterial infections and cancer Ibrahim UH; Devnarain N; Mohammed M; Omolo CA; Gafar MA; Salih M; Pant A; Shunmugam L; Mocktar C; Khan R; Oh JK; Govender T; 36150574
CHEMBIOCHEM
13 Synthesis of a Convertible Linker Containing a Disulfide Group for Oligonucleotide Functionalization Pontarelli A; Liu JT; Movasat H; Ménard S; Oh JK; Wilds CJ; 35863757
CHEMBIOCHEM
14 Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide Choi M; Jazani AM; Oh JK; Noh SM; 35683912
CHEMBIOCHEM
15 Dynamic and Reprocessable Fluorinated Poly(hindered urea) Network Materials Containing Ionic Liquids to Enhance Triboelectric Performance Nellepalli P; Kim MP; Park J; Noh SM; Ye Z; Jung HW; Ko H; Oh JK; 35385641
CHEMBIOCHEM
16 Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA; 35019380
CHEMBIOCHEM
17 Dynamic Covalent Polyurethane Network Materials: Synthesis and Self-healability Nellepalli P; Patel T; Oh JK; 34418209
CHEMBIOCHEM
18 Designing Ultrasmall Carbon Nanospheres with Tailored Sizes and Textural Properties for High-Rate High-Energy Supercapacitors Liu X; Vadiyar MM; Oh JK; Ye Z; 34229427
CHEMBIOCHEM
19 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
20 Macromolecularly Engineered Thermoreversible Heterogeneous Self-Healable Networks Encapsulating Reactive Multidentate Block Copolymer-Stabilized Carbon Nanotubes Zhang G; Patel T; Nellepalli P; Bhagat S; Hase H; Jazani AM; Salzmann I; Ye Z; Oh JK; 33988899
CHEMBIOCHEM
21 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
22 Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles. Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG 31820915
CHEMBIOCHEM
23 Direct Polymerization Approach to Synthesize Acid-Degradable Block Copolymers Bearing Imine Pendants for Tunable pH-Sensitivity and Enhanced Release. Hu X, Oh JK 32964550
CHEMBIOCHEM
24 Self-Healable Reprocessable Triboelectric Nanogenerators Fabricated with Vitrimeric Poly(hindered Urea) Networks. Patel T, Kim MP, Park J, Lee TH, Nellepalli P, Noh SM, Jung HW, Ko H, Oh JK 32840992
CHEMBIOCHEM
25 Dual Reduction/Acid-Responsive Disassembly and Thermoresponsive Tunability of Degradable Double Hydrophilic Block Copolymer. Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK 32118189
CHEMBIOCHEM
26 Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants. Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK 31459031
CHEMBIOCHEM
27 Reduction-Responsive Sheddable Carbon Nanotubes Dispersed in Aqueous Solution. An SY, Sun S, Oh JK 26890479
CNSR
28 Intracellular Delivery of Colloidally Stable Core-Cross-Linked Triblock Copolymer Micelles with Glutathione-Responsive Enhanced Drug Release for Cancer Therapy. Biswas D, An SY, Li Y, Wang X, Oh JK 28207270
CHEMBIOCHEM
29 Multiblock Copolymer-Based Dual Dynamic Disulfide and Supramolecular Crosslinked Self-Healing Networks. An SY, Noh SM, Oh JK 28221703
CHEMBIOCHEM
30 Enhancing targeted antibiotic therapy via pH responsive solid lipid nanoparticles from an acid cleavable lipid. Kalhapure RS, Sikwal DR, Rambharose S, Mocktar C, Singh S, Bester L, Oh JK, Renukuntla J, Govender T 28434930
CHEMBIOCHEM
31 Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery. Bawa KK, Oh JK 28493712
CHEMBIOCHEM
32 Polymers in Drug Delivery: Chemistry and Applications. Oh JK 28780874
CHEMBIOCHEM
33 Thermally Labile Self-Healable Branched Gel Networks Fabricated by New Macromolecular Engineering Approach Utilizing Thermoreversibility. Jung S, Patel T, Oh JK 29210490
CHEMBIOCHEM
34 Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery. Hong SH, Patel T, Ip S, Garg S, Oh JK 29485889
CHEMBIOCHEM
35 Dual disassembly and biological evaluation of enzyme/oxidation-responsive polyester-based nanoparticulates for tumor-targeting delivery. Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK 30223243
CHEMBIOCHEM
36 PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations. Bawa KK, Jazani AM, Shetty C, Oh JK 30286258
CHEMBIOCHEM
37 Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment. Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D 30604607
CHEMBIOCHEM

 

Title:Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.
Authors:Huang Y,  Jazani AM,  Howell EP,  Reynolds LA,  Oh JK,  Moffitt MG
Link:https://www.ncbi.nlm.nih.gov/pubmed/33455300
DOI:10.1021/acsbiomaterials.0c00896
Publication:ACS biomaterials science & engineering
Keywords:directed self-assembly;  drug delivery;  microfluidics;  nanoparticles;  reduction-responsive block copolymers; 
PMID:33455300 Category:ACS Biomater Sci Eng Date Added:2021-01-20
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.
2 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
3 Department of Biochemistry and Microbiology, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Description:

Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

ACS Biomater Sci Eng. 2020 Sep 14; 6(9):5069-5083

Authors: Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

Abstract

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of the physicochemical properties of GSH-responsive PNPs containing cleavable disulfide groups in two different locations (core and interface, DualM PNPs). In this paper, we employ a two-phase gas-liquid microfluidic reactor for the flow-directed manufacturing of paclitaxel-loaded or DiI-loaded DualM PNPs (PAX-PNPs or DiI-PNPs, where DiI is a fluorescent drug surrogate dye). We find that both PAX-PNPs and DiI-PNPs exhibit similar flow-tunable sizes, morphologies, and internal structures to those previously described for empty DualM PNPs. Fluorescent imaging of DiI-PNP formulations shows that microfluidic manufacturing greatly improves the homogeneity of drug dispersion within the PNP population compared to standard bulk microprecipitation. Encapsulation of PAX in DualM PNPs significantly increases its selectivity to cancerous cells, with various PAX-PNP formulations showing higher cytotoxicity against cancerous MCF-7 cells than against non-cancerous HaCaT cells, in contrast to free PAX, which showed similar cytotoxicity in the two cell lines. In addition, the characterization of DualM PNP formulations formed at various microfluidic flow rates reveals that critical figures of merit for drug delivery function-including encapsulation efficiencies, GSH-triggered release rates, rates of cell uptake, cytotoxicities, and selectivity to cancerous cells-exhibit microfluidic flow tunability that mirrors trends in PNP size. These results highlight the potential of two-phase microfluidic manufacturing for controlling both structure and drug delivery function of biological stimuli-responsive nanomedicines toward improved therapeutic outcomes.

PMID: 33455300 [PubMed - in process]




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