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PubMed Publications| Keyword search (4,163 papers available) |  |
"Li W" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging | Kendzerska T; Mallick R; Li W; Robillard R; Taler V; Webber C; Saymeh M; Dang-Vu TT; Tanuseputro P; Fiedorowicz JG; | 41632160 HKAP |
| 2 | Solid solvation structure design improves all-solid-state organic batteries | Hu Y; Su H; Fu J; Luo J; Yu Q; Zhao F; Li W; Deng S; Liu Y; Yuan Y; Gan Y; Wang Y; Kim JT; Chen N; Shakouri M; Hao X; Gao Y; Pang T; Zhang N; Jiang M; Li X; Zhao Y; Tu J; Wang C; Sun X; | 40759737 ENCS |
| 3 | Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles antifungal activities | Li W; Whiteway M; Hang S; Yu J; Lu H; Jiang Y; | 40707518 BIOLOGY |
| 4 | Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species | Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y; | 38929106 BIOLOGY |
| 5 | A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols | Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y; | 36475771 BIOLOGY |
| 6 | Uncovering global-scale risks from commercial chemicals in air | Liu Q; Li L; Zhang X; Saini A; Li W; Hung H; Hao C; Li K; Lee P; Wentzell JJB; Huo C; Li SM; Harner T; Liggio J; | 34912090 CHEMBIOCHEM |
| 7 | Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target | Li W; Shrivastava M; Lu H; Jiang Y; | 33989979 BIOLOGY |
| 8 | Comprehensive evaluation of adsorption performances of carbonaceous materials for sulfonamide antibiotics removal. | Luo B, Huang G, Yao Y, An C, Li W, Zheng R, Zhao K | 32886308 CONCORDIA |
| 9 | An international Delphi consensus study to define motivational communication in the context of developing a training program for physicians. | Dragomir AI, Boucher VG, Bacon SL, Gemme C, Szczepanik G, Corace K, Campbell TS, Vallis MT, Garber G, Rouleau C, Rabi D, Diodati JG, Ghali W, Lavoie KL | 32145022 HKAP |
| Title: | Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles antifungal activities | ||||
| Authors: | Li W, Whiteway M, Hang S, Yu J, Lu H, Jiang Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40707518/ | ||||
| DOI: | 10.1038/s41467-025-62131-z | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 40707518 | Category: | Date Added: | 2025-07-25 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. 2 Department of Biology, Concordia University, Montreal, QC, Canada. 3 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. luhui2019@tongji.edu.cn. 4 Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. jiangyy@tongji.edu.cn. |
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Description: |
Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11 are critical for its interaction with Ncp1, and the Ncp1-Erg11 association is important in azole response. Ellipticine and its analog phiKan 083 block this Erg11-Ncp1 interaction by targeting Ncp1, and boost antifungal effects of fluconazole in vitro and in vivo. A series of steps influencing this process-an initial elevation in reactive oxygen species, leading to protein oxidation and misfolding in the endoplasmic reticulum (ER) that causes ER stress. This stress leads to Ca2+ release from the ER, mitochondrial Ca2+ accumulation and dysfunction, increased ROS production, and apoptosis of C. albicans cells. Overall, disrupting the Erg11-Ncp1 interaction in C. albicans can serve as a useful approach to enhancing the antifungal properties of azoles. |
