PERFORM Publications

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Title		Authors	PubMed ID
1	The effects of intranasal oxytocin on the efficacy of psychotherapy for major depressive disorder: a pilot randomized controlled trial	Ellenbogen MA; Cardoso C; Serravalle L; Vadaga K; Joober R;	38445382 PSYCHOLOGY
2	DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women	Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É;	35703085 PSYCHOLOGY
3	Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis.	MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN	29582562 CONCORDIA
4	Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.	Linnen AM, Ellenbogen MA, Cardoso C, Joober R	22044077 CRDH
5	The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.	Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R	22092248 PSYCHOLOGY
6	Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.	Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R	22889586 PSYCHOLOGY
7	Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.	Ellenbogen MA, Linnen AM, Cardoso C, Joober R	22902063 PSYCHOLOGY
8	Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.	Ellenbogen MA, Linnen AM, Cardoso C, Joober R	25082371 CRDH
9	Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.	Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M	30514643 PSYCHOLOGY
10	A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women	Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E	30693739 PSYCHOLOGY

Title:	Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.
Authors:	Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M
Link:	https://www.ncbi.nlm.nih.gov/pubmed/30514643?dopt=Abstract
Publication:
Keywords:
PMID:	30514643	Category:	Schizophr Res	Date Added:	2019-06-03
Dept Affiliation:	PSYCHOLOGY 1 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: genevieve.sauve@mail.mcgill.ca. 2 Department of Psychology, Concordia University, 7141 Sherbrooke West, Montreal, Quebec H4B 1R6, Canada. Electronic address: rex.kline@concordia.ca. 3 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: jai.shah@mcgill.ca. 4 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: ridha.joober@douglas.mcgill.ca. 5 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: ashok.malla@mcgill.ca. 6 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: mathieu.brodeur@douglas.mcgill.ca. 7 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address: martin.lepage@mcgill.ca.

Description:

Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.

Schizophr Res. 2019 Apr;206:236-243

Authors: Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M

Abstract

BACKGROUND: Lack of insight is a frequent characteristic of psychotic disorders, both in patients who recently experienced a first episode of psychosis (FEP) and those who experience recurrent multiple episodes (MEP). Insight is a multifaceted construct: its clinical form notably includes the unawareness of being ill, of symptoms, and of the need for treatment. Cognitive capacity is among the key determinants of insight into symptoms, but less is known about whether stage of illness (FEP vs. MEP) moderates this association.

METHODS: Our aim is to evaluate the association between cognitive capacity and symptom unawareness using structural equation modeling and moderated multiple regression. A total of 193 FEP and MEP patients were assessed using the CogState battery and the Scale to Assess Unawareness of Mental Disorder.

RESULTS: Analyses suggest that cognitive capacity accounts for a relatively small proportion of the total variation in symptom unawareness (6.4%). There was no evidence to suggest a moderating effect of stage of illness on this association.

CONCLUSIONS: The effect of general cognitive capacity on symptom unawareness is relatively small, and this basic relation was unrelated to stage of illness. It is possible that stage of illness could moderate this association only for certain facets of insight not assessed in this study (e.g., unawareness of the need for treatment).

PMID: 30514643 [PubMed - in process]

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