PERFORM Publications

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Title		Authors	PubMed ID
1	The effects of intranasal oxytocin on the efficacy of psychotherapy for major depressive disorder: a pilot randomized controlled trial	Ellenbogen MA; Cardoso C; Serravalle L; Vadaga K; Joober R;	38445382 PSYCHOLOGY
2	DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women	Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É;	35703085 PSYCHOLOGY
3	Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis.	MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN	29582562 CONCORDIA
4	Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.	Linnen AM, Ellenbogen MA, Cardoso C, Joober R	22044077 CRDH
5	The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.	Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R	22092248 PSYCHOLOGY
6	Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.	Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R	22889586 PSYCHOLOGY
7	Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.	Ellenbogen MA, Linnen AM, Cardoso C, Joober R	22902063 PSYCHOLOGY
8	Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.	Ellenbogen MA, Linnen AM, Cardoso C, Joober R	25082371 CRDH
9	Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.	Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M	30514643 PSYCHOLOGY
10	A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women	Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E	30693739 PSYCHOLOGY

Title:	A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women
Authors:	Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E
Link:	https://www.ncbi.nlm.nih.gov/pubmed/30693739?dopt=Abstract
Publication:
Keywords:
PMID:	30693739	Category:	J Psychiatry Neurosci	Date Added:	2019-06-03
Dept Affiliation:	PSYCHOLOGY 1 From the Eating Disorders Program, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Israël, St-Hilaire, Rossi); the Research Centre, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Joober, Israël, St-Hilaire, Rossi); the Department of Psychiatry, McGill University (Steiger, Booij, Thaler, Joober, Israël, St-Hilaire); the Department of Psychology, Concordia University (Booij); the Sainte-Justine Hospital Research Centre, University of Montreal (Booij); the Department of Epidemiology, Biostatistics, and Occupational Health, McGill University (McGregor); the Department of Decision Sciences, HEC Montreal (Labbe); the Department of Pharmacology and Therapeutics, McGill University (Szyf); the School of Human Nutrition, McGill University (Agellon); and the Centre de recherche du Centre Hospitalier, de l’Université de Montréal (CRCHUM) (Gauvin), Montreal, Que., Canada.

Description:

A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

J Psychiatry Neurosci. 2019 05 01;44(3):205-213

Authors: Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

Abstract

Background: This study explored state-related tendencies in DNA methylation in people with anorexia nervosa.

Methods: We measured genome-wide DNA methylation in 75 women with active anorexia nervosa (active), 31 women showing stable remission of anorexia nervosa (remitted) and 41 women with no eating disorder (NED). We also obtained post-intervention methylation data from 52 of the women from the active group.

Results: Comparisons between members of the active and NED groups showed 58 differentially methylated sites (Q < 0.01) that corresponded to genes relevant to metabolic and nutritional status (lipid and glucose metabolism), psychiatric status (serotonin receptor activity) and immune function. Methylation levels in members of the remitted group differed from those in the active group on 265 probes that also involved sites associated with genes for serotonin and insulin activity, glucose metabolism and immunity. Intriguingly, the direction of methylation effects in remitted participants tended to be opposite to those seen in active participants. The chronicity of Illness correlated (usually inversely, at Q < 0.01) with methylation levels at 64 sites that mapped onto genes regulating glutamate and serotonin activity, insulin function and epigenetic age. In contrast, body mass index increases coincided (at Q < 0.05) with generally increased methylation-level changes at 73 probes associated with lipid and glucose metabolism, immune and inflammatory processes, and olfaction.

Limitations: Sample sizes were modest for this type of inquiry, and findings may have been subject to uncontrolled effects of medication and substance use.

Conclusion: Findings point to the possibility of reversible epigenetic alterations in anorexia nervosa, and suggest that an adequate pathophysiological model would likely need to include psychiatric, metabolic and immune components.

PMID: 30693739 [PubMed - in process]

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