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PubMed Publications| Keyword search (4,163 papers available) |  |
"Intzandt B" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 4 | Alzheimer s Imaging Consortium | Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ; | 41433411 CONCORDIA |
| 5 | Public Health | Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ; | 41435069 CONCORDIA |
| 6 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 7 | Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer s disease | Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None; | 40347524 CONCORDIA |
| 8 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 40079560 SOH |
| 9 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 39416007 SOH |
| 10 | Multiple routes to help you roam: A comparison of training interventions to improve cognitive-motor dual-tasking in healthy older adults | Downey R; Bherer L; Pothier K; Vrinceanu T; Intzandt B; Berryman N; Lussier M; Vincent T; Karelis AD; Nigam A; Vu TTM; Bosquet L; Li KZH; | 36408116 PERFORM |
| 11 | Mastering the Relationship between the Body and the Brain? The Case of a Female Master Athlete | Saillant K; Intzandt B; Bérubé B; Sanami S; Gauthier C; Bherer L; | 35950796 PERFORM |
| 12 | A comparison of the effect of physical activity and cognitive training on dual-task performance in older adults | Vrinceanu T; Blanchette CA; Intzandt B; Lussier M; Pothier K; Vu TTM; Nigam A; Bosquet L; Karelis AD; Li KZH; Berryman N; Bherer L; | 34865009 PERFORM |
| 13 | Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults | Sabra D; Intzandt B; Desjardins-Crepeau L; Langeard A; Steele CJ; Frouin F; Hoge RD; Bherer L; Gauthier CJ; | 34582484 PERFORM |
| 14 | Comparing the effect of Cognitive vs. Exercise Training on brain MRI outcomes in healthy older adults: A systematic review | Intzandt B; Vrinceanu T; Huck J; Vincent T; Montero-Odasso M; Gauthier CJ; Bherer L; | 34245760 PERFORM |
| 15 | A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults | Pothier K; Vrinceanu T; Intzandt B; Bosquet L; Karelis AD; Lussier M; Vu TTM; Nigam A; Li KZH; Berryman N; Bherer L; | 33774144 PERFORM |
| 16 | Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults. | Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ | 31342831 PERFORM |
| 17 | The effects of exercise on cognition and gait in Parkinson's disease: A scoping review. | Intzandt B, Beck EN, Silveira CRA | 30291852 PERFORM |
| Title: | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | ||||
| Authors: | Sanami S, Rezaei A, Tremblay SA, Potvin-Jutras Z, Sabra D, Intzandt B, Gagnon C, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41543005/ | ||||
| DOI: | 10.1177/0271678X251413924 | ||||
| Publication: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | ||||
| Keywords: | Cerebral blood flow; cerebral metabolic rate of oxygen consumption; dual calibrated functional MRI; oxygen extraction fraction; quantitative susceptibility mapping; | ||||
| PMID: | 41543005 | Category: | Date Added: | 2026-01-16 | |
| Dept Affiliation: |
SOH
1 Department of Physics, Concordia University, Montreal, QC, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, Canada. 3 School of Health, Concordia University, Montreal, QC, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada. 5 BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada. 6 Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada. |
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Description: |
Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain health, particularly higher gray matter volume and perfusion. The brain relies heavily on oxidative metabolism, yet the relationship between cardiorespiratory fitness and brain oxidative metabolism remains underexplored. This study investigated the association between VO2peak and two key cerebral metabolic parameters: the cerebral metabolic rate of oxygen consumption (CMRO2) and oxygen extraction fraction (OEF), which represents the balance between cerebral blood flow (CBF) and CMRO2. Thirty-seven healthy adults aged ?50 underwent maximal cardiopulmonary exercise testing for VO2peak assessment. Neuroimaging included dual calibrated functional MRI (dc-fMRI) and quantitative susceptibility mapping (QSM). Higher VO2peak correlated positively with higher CBF across whole-brain gray matter but showed no relationship with CMRO2. Conversely, higher VO2peak negatively correlated with lower OEF from both dc-fMRI and QSM. These findings suggest that greater cardiorespiratory fitness enhances cerebral perfusion without changing resting metabolic rate in healthy older adults, resulting in a reduced oxygen extraction. These results are consistent with exercise yielding improved vascular-metabolic coupling, which would reduce the likelihood of transient hypoxic episodes. |
