Keyword search (4,163 papers available)

"Helfield B" Authored Publications:

Title Authors PubMed ID
1 Thermal sonogenetics for adoptive cell transfer therapy Baez A; Hazel K; Guertin Z; Fong E; Manus MM; Kaloyannis A; Helfield B; 41748028
BIOLOGY
2 Shear Stress and Microbubble-Mediated Modulation of Endothelial Cell Immunobiology Memari E; Singh D; Alkins R; Helfield B; 40657183
PHYSICS
3 Deformable detection transformers for domain adaptable ultrasound localization microscopy with robustness to point spread function variations Gharamaleki SK; Helfield B; Rivaz H; 40640235
PHYSICS
4 Investigation of Phase-Change Droplets and Fast Imaging for Indicator Dilution Measurement of Flow Zajac Z; Helfield B; Williams R; Sheeran P; Tremblay-Darveau C; Yoo K; Burns PN; 40387284
BIOLOGY
5 Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA He S; Singh D; Helfield B; 39850318
BIOLOGY
6 Focused Ultrasound and Microbubble-Mediated Delivery of CRISPR-Cas9 Ribonucleoprotein to Human Induced Pluripotent Stem Cells Hazel K; Singh D; He S; Guertin Z; Husser MC; Helfield B; 39797397
BIOLOGY
7 The effect of micro-vessel viscosity on the resonance response of a two-microbubble system Yusefi H; Helfield B; 39705920
BIOLOGY
8 Immunomodulation of human T cells by microbubble-mediated focused ultrasound Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B; 39502696
BIOLOGY
9 Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization Memari E; Helfield B; 38988819
BIOLOGY
10 Cardiac gene delivery using ultrasound: State of the field Singh D; Memari E; He S; Yusefi H; Helfield B; 38983873
BIOLOGY
11 Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer Memari E; Khan D; Alkins R; Helfield B; 38266715
BIOLOGY
12 Subharmonic resonance of phospholipid coated ultrasound contrast agent microbubbles Yusefi H; Helfield B; 38217906
BIOLOGY
13 Cavitation-Enhanced Drug Delivery and Immunotherapy Helfield B; Sirsi S; Kwan J; Gray M; 37765176
PHYSICS
14 Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux Memari E; Hui F; Yusefi H; Helfield B; 37150403
PHYSICS
15 Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells He S; Singh D; Yusefi H; Helfield B; 36559150
BIOLOGY
16 The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles Yusefi H; Helfield B; 36223708
BIOLOGY
17 An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery He S; Singh D; Helfield B; 35456718
BIOLOGY
18 Lateral Position-Dependent Velocity Estimation Error in Plane-Wave Doppler Ultrasound Systems Wei L; Williams R; Loupas T; Helfield B; Burns PN; 34006440
IMAGING
19 Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation. Helfield B, Chen X, Watkins SC, Villanueva FS 32402675
BIOLOGY

 

Title:The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles
Authors:Yusefi HHelfield B
Link:https://pubmed.ncbi.nlm.nih.gov/36223708/
DOI:10.1016/j.ultsonch.2022.106191
Publication:Ultrasonics sonochemistry
Keywords:Bubble dynamicsCavitationFinite elementNanobubblesNon-spherical vibrationNonlinear
PMID:36223708 Category: Date Added:2022-10-27
Dept Affiliation: BIOLOGY
1 Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada.
2 Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. Electronic address: brandon.helfield@concordia.ca.

Description:

Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant scatterers that are employed as diagnostic contrast agents and emerging as potentiators of targeted therapies. Microbubbles are administered in populations whereby their radial dynamics - key to their effectiveness - are greatly affected by intrinsic (e.g. bubble size) and extrinsic (e.g. boundaries) factors. In this work, we aim to understand how two neighbouring microbubbles influence each other. We developed a finite element model of a system of two individual phospholipid-encapsulated microbubbles vibrating in proximity to each other to study the effect of inter-bubble distance on microbubble radial resonance response. For the case of two equal-sized and identical bubbles, each bubble exhibits a decrease between 7 and 10% in the frequency of maximum response (fMR) and an increase in amplitude of maximum response (AMR) by 9-11% as compared to its isolated response in free-space, depending on the bubble size examined. For a system of two unequal-sized microbubbles, the large bubble shows no significant change, however the smaller microbubble shows an increase in fMR by 7-11% and a significant decrease in AMR by 38-52%. Furthermore, in very close proximity the small bubble shows a secondary off-resonance peak at the corresponding fMR of its larger companion microbubble. Our work suggests that frequency-dependent microbubble response is greatly affected by the presence of another bubble, which has implications in both imaging and therapy applications. Furthermore, our work suggests a mechanism by which nanobubbles show significant off-resonance vibrations in the clinical frequency range, a behaviour that has been observed experimentally but heretofore unexplained.





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