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PubMed Publications| Keyword search (4,163 papers available) |  |
"Gamberi C" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | TANGO2 deficiency disease is predominantly caused by a lipid imbalance | Sacher M; DeLoriea J; Mehranfar M; Casey C; Naaz A; Gamberi C; | 38836374 BIOLOGY |
| 2 | Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells | Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M; | 36502486 BIOLOGY |
| 3 | Empowering Melatonin Therapeutics with Drosophila Models | Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C; | 34698120 BIOLOGY |
| 4 | Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease. | Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C; | 33238462 BIOLOGY |
| 5 | Drug discovery and chemical probing in Drosophila. | Millet-Boureima C, Selber-Hnatiw S, Gamberi C | 32551911 BIOLOGY |
| 6 | Editorial: RNA Regulation in Development and Disease. | Chartrand P, Jaramillo M, Gamberi C | 32411184 BIOLOGY |
| 7 | Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics. | Millet-Boureima C, Chingle R, Lubell WD, Gamberi C | 31635379 BIOLOGY |
| 8 | Modeling Renal Disease "On the Fly". | Millet-Boureima C, Porras Marroquin J, Gamberi C | 29955604 BIOLOGY |
| 9 | Mapping the fly Malpighian tubule lipidome by imaging mass spectrometry | Yang E; Gamberi C; Chaurand P; | 31038251 BIOLOGY |
| Title: | Empowering Melatonin Therapeutics with Drosophila Models | ||||
| Authors: | Millet-Boureima C, Ennis CC, Jamison J, McSweeney S, Park A, Gamberi C | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34698120/ | ||||
| DOI: | 10.3390/diseases9040067 | ||||
| Publication: | Diseases (Basel, Switzerland) | ||||
| Keywords: | Drosophila; PKD; longevity; melatonin; neurodegeneration; oxidative stress; | ||||
| PMID: | 34698120 | Category: | Date Added: | 2021-10-26 | |
| Dept Affiliation: |
BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada. 2 Department of Biology, Coastal Carolina University, Conway, SC 29528-6054, USA. |
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Description: |
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis and discover new drugs. Here, we review the multiple functions of melatonin through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases. |
