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PubMed Publications| Keyword search (4,163 papers available) |  |
"Frauscher B" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 2 | Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy | Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasconi A; Bernasconi N; Bernhardt BC; | 41258102 SOH |
| 3 | Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study | Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L; Chabardes S; Colnat-Coulbois S; Maillard L; Hall J; Dubeau F; Gotman J; Grova C; Frauscher B; | 40519108 SOH |
| 4 | Spectral and network investigation reveals distinct power and connectivity patterns between phasic and tonic REM sleep | Avigdor T; Peter-Derex L; Ho A; Schiller K; Wang Y; Abdallah C; Delaire E; Jaber K; Travnicek V; Grova C; Frauscher B; | 40394955 SOH |
| 5 | The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies | Avigdor T; Ren G; Abdallah C; Dubeau F; Grova C; Frauscher B; | 40126936 PERFORM |
| 6 | Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology | Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klimes P; Frauscher B; | 39608298 SOH |
| 7 | NREM sleep brain networks modulate cognitive recovery from sleep deprivation | Lee K; Wang Y; Cross NE; Jegou A; Razavipour F; Pomares FB; Perrault AA; Nguyen A; Aydin Ü; Uji M; Abdallah C; Anticevic A; Frauscher B; Benali H; Dang-Vu TT; Grova C; | 39005401 PERFORM |
| 8 | EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy | Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C; | 38994740 SOH |
| 9 | A spatial perturbation framework to validate implantation of the epileptogenic zone | Jaber K; Avigdor T; Mansilla D; Ho A; Thomas J; Abdallah C; Chabardes S; Hall J; Minotti L; Kahane P; Grova C; Gotman J; Frauscher B; | 38897997 SOH |
| 10 | Systematic review of seizure-onset patterns in stereo-electroencephalography: Current state and future directions | Abdallah C; Mansilla D; Minato E; Grova C; Beniczky S; Frauscher B; | 38733701 PERFORM |
| 11 | Consistency of electrical source imaging in presurgical evaluation of epilepsy across different vigilance states | Avigdor T; Abdallah C; Afnan J; Cai Z; Rammal S; Grova C; Frauscher B; | 38217279 PERFORM |
| 12 | Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy | Horrillo-Maysonnial A; Avigdor T; Abdallah C; Mansilla D; Thomas J; von Ellenrieder N; Royer J; Bernhardt B; Grova C; Gotman J; Frauscher B; | 37704552 PERFORM |
| 13 | Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas | Afnan J; von Ellenrieder N; Lina JM; Pellegrino G; Arcara G; Cai Z; Hedrich T; Abdallah C; Khajehpour H; Frauscher B; Gotman J; Grova C; | 37149236 PERFORM |
| 14 | Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy | Frauscher B; Bénar CG; Engel JJ; Grova C; Jacobs J; Kahane P; Wiebe S; Zjilmans M; Dubeau F; | 37119580 PERFORM |
| 15 | Clinical Yield of Electromagnetic Source Imaging and Hemodynamic Responses in Epilepsy: Validation With Intracerebral Data | Abdallah C; Hedrich T; Koupparis A; Afnan J; Hall JA; Gotman J; Dubeau F; von Ellenrieder N; Frauscher B; Kobayashi E; Grova C; | 35473762 PERFORM |
| 16 | Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography. | Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B | 33450578 PERFORM |
| Title: | Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy | ||||
| Authors: | Xie K, Sahlas E, Ngo A, Chen J, Arafat T, Royer J, Zhou Y, Rodríguez-Cruces R, Dascal A, Caldairou B, Fadaie F, Barnett A, Audrain S, Larivière S, Caciagli L, Pana R, Weil AG, Grova C, Frauscher B, Schrader DV, Zhang Z, Concha L, Bernasconi A, Bernasconi N, Bernhardt BC | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41258102/ | ||||
| DOI: | 10.1038/s41467-025-65042-1 | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 41258102 | Category: | Date Added: | 2025-11-19 | |
| Dept Affiliation: |
SOH
1 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. ke.xie@mail.mcgill.ca. 2 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. 3 Sherbrooke Laboratory for Integrative Connectomics, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada. 4 Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern, Switzerland. 5 Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. 6 Division of Neurosurgery, Department of Surgery, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. 7 Multimodal Functional Imaging Lab, Department of Physics and Concordia School of Health, Concordia University, Montreal, QC, Canada. 8 Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Montreal, QC, Canada. 9 Department of Neurology, Department of Biomedical Engineering, Duke University, Durham, NC, USA. 10 British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada. 11 Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China. 12 Institute of Neurobiology, Universidad Nacional Autónoma de Mexico, Queretaro, Mexico. 13 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca. |
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Description: |
Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 disease controls. Patient-specific deviations from typical lifespan trajectories of intrinsic brain function were mapped using normative modeling. Regional functional alterations were heterogeneous but overlapped most in the mesiotemporal cortex. Connectome-based simulations revealed abnormality spread followed structural network architecture, highlighting the hippocampus as well as paralimbic and medial default-mode regions as epicenters. Multimodal integration implicated superficial white-matter microstructural alterations as a key contributor. Supervised models achieved AUCs of 0.77 for distinguishing TLE from disease controls, 0.74 for lateralizing seizure focus, and 0.64 for predicting postsurgical seizure freedom; greater contralateral temporal deviations predicted poorer outcomes. These findings support individualized functional biomarkers for precision presurgical care in focal epilepsy. |
