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PubMed Publications| Keyword search (4,163 papers available) |  |
"Fraser S" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 2 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 3 | Public Health | Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M; | 41435121 CONCORDIA |
| 4 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 5 | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; | 37471089 PERFORM |
| 6 | Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults | Bherer L; Gagnon C; Langeard A; Lussier M; Desjardins-Crépeau L; Berryman N; Bosquet L; Vu TTM; Fraser S; Li KZH; Kramer AF; | 32803232 PERFORM |
| 7 | Ageism and COVID-19: What does our society's response say about us? | Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beaulieu M, Bergeron CD, Boudjemadi V, Desmette D, Donizzetti AR, Éthier S, Garon S, Gillis M, Levasseur M, Lortie-Lussier M, Marier P, Robitaille A, Sawchuk K, Lafontaine C, Tougas F | 32377666 PSYCHOLOGY |
| 8 | Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson Y, Beauchet O, McFadyen BJ, Morais JA, Camicioli R, Canadian Gait and Cognition Network | 29977431 ENCS |
| 9 | SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. | Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L | 29661156 PERFORM |
| 10 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| 11 | Age-related decline in divided-attention: from theoretical lab research to practical real-life situations. | Fraser S, Bherer L | 26304268 PERFORM |
| 12 | The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults. | Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L | 26063061 PERFORM |
| 13 | Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients. | Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A | 26577897 PERFORM |
| Title: | Public Health | ||||
| Authors: | Pieruccini-Faria F, Son S, Liu-Ambrose T, Burhan AM, Almeida QJ, Middleton LE, Li K, Fraser S, Bherer L, Montero-Odasso M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41435121/ | ||||
| DOI: | 10.1002/alz70860_103664 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | |||||
| PMID: | 41435121 | Category: | Date Added: | 2025-12-23 | |
| Dept Affiliation: |
CONCORDIA
1 Gait and Brain Laboratory, Parkwood Institute, London, ON, Canada. 2 Gait & Brain Lab; Lawson Research Institute; Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 3 Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. 4 Parkwood Institute, London, ON, Canada. 5 Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 6 Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 7 University of British Columbia, Vancouver, BC, Canada. 8 Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. 9 University of Toronto, Toronto, ON, Canada. 10 Care Space Health, Waterloo, ON, Canada. 11 Schlegel-UW Research Institute for Aging, Waterloo, ON, Canada. 12 University of Waterloo, Waterloo, ON, Canada. 13 Concordia University, Montreal, QC, Canada. 14 University of Ottawa, Ottawa, ON, Canada. 15 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. 16 University of Montreal, Montreal, QC, Canada. 17 Schulich School of Medicine & Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. |
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Description: |
Background: Mild Cognitive Impairment (MCI) may be associated with the presence of the apolipoprotein E4 allele (APOE4), a genetic factor linked to accelerated cognitive decline. The SYNERGIC trial demonstrated that physical exercise (PE) involving aerobic and resistance training improves global cognition in individuals with MCI, with significantly enhanced benefits of cognitive training but not vitamin D. The role of APOE4 status in responsiveness to these interventions remains unclear. Method: Of 175 participants in the SYNERGIC trial, 80 underwent APOE4 genotyping. This study analyzed 67 participants (mean age: 73.8 years; 43.2% women) who completed a 6-month multidomain intervention across four arms: (1) PE + Cognitive training (Neuropeak®) + Vitamin D; (2) PE + Cognitive training; (3) PE + Vitamin D; and (4) PE alone. Changes in global cognition (ADAS-Cog-13) were compared between APOE4-positive and APOE4-negative individuals using ANOVA. Result: APOE4-positive participants showed attenuated global cognitive improvements from multidomain interventions compared to APOE4-negative participants (mean difference = -2.08, 95% CI: -4.18 to 0.11; p = 0.052; d = -0.56). A significant group effect (p = 0.03) revealed that the PE + Vitamin D arm worsened global cognition over time compared to all other arms, with significant decline relative to the arm receiving all three interventions (p = 0.02). Sensitivity analysis excluding arms with vitamin D confirmed the attenuated effect of APOE4-positive status on global cognition (mean difference = -2.99, 95% CI: -6.10 to 0.11; p = 0.05; d = -0.78). Conclusion: Individuals with MCI and APOE4-positive status exhibit reduced responsiveness to multidomain interventions for global cognition, likely due to underlying genetic neurodegeneration. |
