Keyword search (4,163 papers available)

"Cox SML" Authored Publications:

Title Authors PubMed ID
1 A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; 39725679
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2 Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation Scala SG; Kang MS; Cox SML; Rosa-Neto P; Massarweh G; Leyton M; 38221806
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3 Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M; 34463411
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4 mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M 32413893
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5 Extra-striatal D2/3 receptor availability in youth at risk for addiction. Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M 32259831
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6 Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans. Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M 30607444
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7 Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors. Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M 30627817
CSBN

 

Title:mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.
Authors:Cox SML,  Tippler M,  Jaworska N,  Smart K,  Castellanos-Ryan N,  Durand F,  Allard D,  Benkelfat C,  Parent S,  Dagher A,  Vitaro F,  Boivin M,  Pihl RO,  Côté S,  Tremblay RE,  Séguin JR,  Leyton M
Link:https://www.ncbi.nlm.nih.gov/pubmed/32413893?dopt=Abstract
DOI:10.1038/s41386-020-0708-x
Publication:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Keywords:
PMID:32413893 Category:Neuropsychopharmacology Date Added:2020-05-16
Dept Affiliation: CSBN
1 Department of Psychiatry, McGill University, Montreal, QC, Canada.
2 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
3 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
4 Institute of Mental Health Research, Affiliated with the University of Ottawa, Ottawa, ON, Canada.
5 Yale PET Center, Yale University, New Haven, CT, USA.
6 School of Psychoeducation, Université de Montréal, Montreal, QC, Canada.
7 CHU Ste-Justine Research Center, Montreal, QC, Canada.
8 Department of Psychology, Université Laval, Quebec, QC, Canada.
9 Department of Psychology, McGill University, Montreal, QC, Canada.
10 Department of Social and Preventative Medicine, Université de Montréal, Montreal, QC, Canada.
11 Department of Pediatrics and Psychology, Université de Montréal, Montreal, QC, Canada.
12 School of Public Health, University College Dublin, Belfield, Dublin, Ireland.
13 Department of Psychiatry and Addictology, Université de Montréal, Montreal, QC, Canada.
14 Department of Psychiatry, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
15 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
16 Department of Psychology, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
17 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. marco.leyton@mcgill.ca.

Description:

mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Neuropsychopharmacology. 2020 May 15;:

Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M

Abstract

The excitatory neurotransmitter glutamate has been implicated in experience-dependent neuroplasticity and drug-seeking behaviors. Type 5 metabotropic glutamate (mGlu5) receptors might be particularly important. They are critically involved in synaptic plasticity and their availability has been reported to be lower in people with alcohol, tobacco, and cocaine use disorders. Since these reductions could reflect effects of drug use or pre-existing traits, we used positron emission tomography to measure mGlu5 receptor availability in young adults at elevated risk for addictions. Fifty-nine participants (age 18.5±0.6) were recruited from a longitudinal study that has followed them since birth. Based on externalizing traits that predict future substance use problems, half were at low risk, half were at high risk. Cannabis use histories varied markedly and participants were divided into three subgroups: zero, low, and high use. Compared to low risk volunteers, those at elevated risk had lower [11C]ABP688 binding potential (BPND) values in the striatum, amygdala, insula, and orbitofrontal cortex (OFC). Cannabis use by risk group interactions were observed in the striatum and OFC. In these regions, low [11C]ABP688 BPND values were only seen in the high risk group that used high quantities of cannabis. When these high risk, high cannabis use individuals were compared to all other participants, [11C]ABP688 BPND values were lower in the striatum, OFC, and insula. Together, the study provides evidence that mGlu5 receptor availability is low in youth at elevated risk for addictions, particularly those who frequently use cannabis.

PMID: 32413893 [PubMed - as supplied by publisher]




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