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Title		Authors	PubMed ID
1	A method of calculating initial DNA strand breakage following the decay of incorporated 125I.	Charlton DE, Humm JL	3257951 PHYSICS
2	Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.	Charlton DE	3353505 PHYSICS
3	Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.	Charlton DE, Nikjoo H, Humm JL	2569005 PHYSICS
4	Cell survival from single passages for high-LET track-segment experiments with cell monolayers.	Charlton DE, Turner MS	8248489 PHYSICS
5	Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.	Charlton DE, Allen BJ	7903342 PHYSICS
6	Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.	Charlton DE, Turner MS	8609458 PHYSICS
7	Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.	Charlton DE, Utteridge TD, Beddoe AH	8648246 PHYSICS
8	The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.	Charlton DE	9611104 PHYSICS
9	The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.	Charlton DE	10360796 PHYSICS
10	Radiation effects in spheroids of cells exposed to alpha emitters.	Charlton DE	11098858 PHYSICS

Title:	Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.
Authors:	Charlton DE, Nikjoo H, Humm JL
Link:	https://www.ncbi.nlm.nih.gov/pubmed/2569005?dopt=Abstract
Publication:
Keywords:
PMID:	2569005	Category:	Int J Radiat Biol	Date Added:	2019-06-04
Dept Affiliation:	PHYSICS

Description:

Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Int J Radiat Biol. 1989 Jul;56(1):1-19

Authors: Charlton DE, Nikjoo H, Humm JL

Abstract

A model of the DNA and electron and ion track structure computer codes are used to model damage in the DNA by direct action. This damage is converted into single-strand breaks using the method described by Charlton and Humm (1988) in which a minimum energy deposited in a critical volume of the DNA is correlated with the production of single-strand breaks. It is then assumed that if these single-strand breaks lie on opposite strands and are separated by less than a few base pairs they produce double-strand breaks. Absolute yields of both single- and double-strand breaks expressed in breaks/Gy-dalton are calculated and compared to measured yields. Good agreement is obtained for single-strand breaks while the calculated yields for double-strand breaks are greater than those measured.

PMID: 2569005 [PubMed - indexed for MEDLINE]

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