Keyword search (4,164 papers available)

"Côté SM" Authored Publications:

Title Authors PubMed ID
1 Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence Dufour R; Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 40883733
PSYCHOLOGY
2 Mental health of Canadian youth: A systematic review and meta-analysis of studies examining changes in depression, anxiety, and suicide-related outcomes during the COVID-19 pandemic Geoffroy MC; Chadi N; Bouchard S; Fuoco J; Chartrand E; Loose T; Sciola A; Boruff JT; Iyer SN; Sun Y; Gouin JP; Côté SM; Thombs BD; 38478216
PSYCHOLOGY
3 Childhood hyperactivity, eating behaviours, and executive functions: Their association with the development of eating-disorder symptoms in adolescence Dufour R; Breton É; Morin AJS; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37833803
PSYCHOLOGY
4 Childhood Overeating and Disordered Eating From Early Adolescence to Young Adulthood: A Longitudinal Study on the Mediating Role of BMI, Victimization and Desire for Thinness Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 37270466
PSYCHOLOGY
5 Developmental trajectories of eating disorder symptoms: A longitudinal study from early adolescence to young adulthood Breton É; Dufour R; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L; 35725645
PSYCHOLOGY
6 Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M; 34085288
PSYCHOLOGY
7 Extra-striatal D2/3 receptor availability in youth at risk for addiction. Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M 32259831
CSBN

 

Title:Extra-striatal D2/3 receptor availability in youth at risk for addiction.
Authors:Jaworska N,  Cox SML,  Tippler M,  Castellanos-Ryan N,  Benkelfat C,  Parent S,  Dagher A,  Vitaro F,  Boivin M,  Pihl RO,  Côté SM,  Tremblay RE,  Séguin JR,  Leyton M
Link:https://www.ncbi.nlm.nih.gov/pubmed/32259831?dopt=Abstract
DOI:10.1038/s41386-020-0662-7
Publication:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Keywords:
PMID:32259831 Category:Neuropsychopharmacology Date Added:2020-04-08
Dept Affiliation: CSBN
1 Institute of Mental Health Research, affiliated with the University of Ottawa, Ottawa, ON, Canada.
2 Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
3 Department of Psychiatry, McGill University, Montreal, QC, Canada.
4 Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
5 School of Psychoeducation, Université de Montréal, Montreal, QC, Canada.
6 CHU Ste-Justine Research Center, Montreal, QC, Canada.
7 Department of Psychology, Université Laval, Montreal, QC, Canada.
8 Department of Psychology, McGill University, Montreal, QC, Canada.
9 Department of Social & Preventative Medicine, Université de Montréal, Montreal, QC, Canada.
10 Department of Pediatrics & Psychology, Université de Montréal, Montreal, QC, Canada.
11 Department of Psychiatry, Université de Montréal, Montreal, QC, Canada.
12 Department of Psychiatry, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
13 Montreal Neurological Institute, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
14 CHU Ste-Justine Research Center, Montreal, QC, Canada. marco.leyton@mcgill.ca.
15 Department of Psychology, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
16 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. marco.leyton@mcgill.ca.

Description:

Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Neuropsychopharmacology. 2020 Apr 07;:

Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M

Abstract

The neurobiological traits that confer risk for addictions remain poorly understood. However, dopaminergic function throughout the prefrontal cortex, limbic system, and upper brainstem has been implicated in behavioral features that influence addiction vulnerability, including poor impulse control and altered sensitivity to rewards and punishments (i.e., externalizing features). To test these associations in humans, we measured type-2/3 dopamine receptor (DA2/3R) availability in youth at high vs. low risk for substance use disorders (SUDs). In this study, N?=?58 youth (18.5?±?0.6?years) were recruited from cohorts that have been followed since birth. Participants with either high (high EXT; N?=?27; 16?F/11?M) or low pre-existing externalizing traits (low EXT; N?=?31; 20?F/11?M) underwent a 90-min positron emission tomography [18F]fallypride scan, and completed the Barratt impulsiveness scale (BIS-11), substance use risk profile scale (SURPS), and sensitivity to punishment and sensitivity to reward (SR) questionnaire. We found that high vs. low EXT trait participants reported elevated substance use, BIS-11, SR, and SURPS impulsivity scores, had a greater prevalence of psychiatric disorders, and exhibited higher [18F]fallypride binding potential (BPND) values in prefrontal, limbic and paralimbic regions, even when controlling for substance use. Group differences were not evident in midbrain dopamine cell body regions, but, across all participants, low midbrain BPND values were associated with low SP scores. Together, the results suggest that altered DA2/3R availability in terminal extra-striatal and dopamine cell body regions might constitute biological vulnerability traits, generating an EXT trajectory for addictions with and without co-occurring alterations in punishment sensitivity (i.e., an internalizing feature).

PMID: 32259831 [PubMed - as supplied by publisher]




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