PERFORM Publications

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Title		Authors	PubMed ID
1	Correction: Polygenic scores of obesity in childhood based on summary statistics from adults versus children	Goulet D; Boivin M; Gravel C; Little J; Ouellet-Morin I; Gouin J; Dubois L;	41182116 CONCORDIA
2	Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence	Dufour R; Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L;	40883733 PSYCHOLOGY
3	Polygenic scores of obesity in childhood based on summary statistics from adults vs. children	Goulet D; Boivin M; Gravel C; Little J; Ouellet-Morin I; Gouin JP; Dubois L;	40132211 CONCORDIA
4	Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences	Bouliane M; Boivin M; Kretschmer T; Lafreniere B; Paquin S; Tremblay R; Côté S; Gouin JP; Andlauer TFM; Petitclerc A; Ouellet-Morin I;	39907790 PSYCHOLOGY
5	A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography	Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M;	39725679 CSBN
6	Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort	Scardera S; Geoffroy MC; Langevin R; Perret LC; Collin-Vézina D; Voronin I; Gouin JP; Meng X; Boivin M; Ouellet-Morin I;	39465601 PSYCHOLOGY
7	Childhood hyperactivity, eating behaviours, and executive functions: Their association with the development of eating-disorder symptoms in adolescence	Dufour R; Breton É; Morin AJS; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L;	37833803 PSYCHOLOGY
8	Childhood Overeating and Disordered Eating From Early Adolescence to Young Adulthood: A Longitudinal Study on the Mediating Role of BMI, Victimization and Desire for Thinness	Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L;	37270466 PSYCHOLOGY
9	Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis	Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M;	37146008 PSYCHOLOGY
10	Depression, anxiety, and suicidal ideation in a population-based cohort of young adults before and during the first 12 months of the COVID-19 pandemic in Canada	Gouin JP; MacNeil S; de la Torre-Luque A; Chartrand E; Chadi N; Rouquette A; Boivin M; Côté S; Geoffroy MC;	37093498 PSYCHOLOGY
11	Pathways of association between disordered eating in adolescence and mental health outcomes in young adulthood during the COVID-19 pandemic	Loose T; Geoffroy MC; Orri M; Chadi N; Scardera S; Booij L; Breton E; Tremblay R; Boivin M; Coté S;	36482144 PSYCHOLOGY
12	Developmental trajectories of eating disorder symptoms: A longitudinal study from early adolescence to young adulthood	Breton É; Dufour R; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L;	35725645 PSYCHOLOGY
13	Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort	Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC;	34496901 PSYCHOLOGY
14	Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood	Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M;	34085288 PSYCHOLOGY
15	Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.	Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij L	32881198 PSYCHOLOGY
16	mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.	Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M	32413893 CSBN
17	Extra-striatal D2/3 receptor availability in youth at risk for addiction.	Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M	32259831 CSBN
18	Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.	Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L	28032437 PSYCHOLOGY
19	Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.	Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L	30089832 PSYCHOLOGY
20	Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.	Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M	30607444 CSBN
21	Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.	Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M	30627817 CSBN

Title:	mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.
Authors:	Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32413893?dopt=Abstract
DOI:	10.1038/s41386-020-0708-x
Publication:	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Keywords:
PMID:	32413893	Category:	Neuropsychopharmacology	Date Added:	2020-05-16
Dept Affiliation:	CSBN 1 Department of Psychiatry, McGill University, Montreal, QC, Canada. 2 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. 3 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. 4 Institute of Mental Health Research, Affiliated with the University of Ottawa, Ottawa, ON, Canada. 5 Yale PET Center, Yale University, New Haven, CT, USA. 6 School of Psychoeducation, Université de Montréal, Montreal, QC, Canada. 7 CHU Ste-Justine Research Center, Montreal, QC, Canada. 8 Department of Psychology, Université Laval, Quebec, QC, Canada. 9 Department of Psychology, McGill University, Montreal, QC, Canada. 10 Department of Social and Preventative Medicine, Université de Montréal, Montreal, QC, Canada. 11 Department of Pediatrics and Psychology, Université de Montréal, Montreal, QC, Canada. 12 School of Public Health, University College Dublin, Belfield, Dublin, Ireland. 13 Department of Psychiatry and Addictology, Université de Montréal, Montreal, QC, Canada. 14 Department of Psychiatry, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca. 15 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca. 16 Department of Psychology, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca. 17 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. marco.leyton@mcgill.ca.

Description:

mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Neuropsychopharmacology. 2020 May 15;:

Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M

Abstract

The excitatory neurotransmitter glutamate has been implicated in experience-dependent neuroplasticity and drug-seeking behaviors. Type 5 metabotropic glutamate (mGlu5) receptors might be particularly important. They are critically involved in synaptic plasticity and their availability has been reported to be lower in people with alcohol, tobacco, and cocaine use disorders. Since these reductions could reflect effects of drug use or pre-existing traits, we used positron emission tomography to measure mGlu5 receptor availability in young adults at elevated risk for addictions. Fifty-nine participants (age 18.5±0.6) were recruited from a longitudinal study that has followed them since birth. Based on externalizing traits that predict future substance use problems, half were at low risk, half were at high risk. Cannabis use histories varied markedly and participants were divided into three subgroups: zero, low, and high use. Compared to low risk volunteers, those at elevated risk had lower [11C]ABP688 binding potential (BPND) values in the striatum, amygdala, insula, and orbitofrontal cortex (OFC). Cannabis use by risk group interactions were observed in the striatum and OFC. In these regions, low [11C]ABP688 BPND values were only seen in the high risk group that used high quantities of cannabis. When these high risk, high cannabis use individuals were compared to all other participants, [11C]ABP688 BPND values were lower in the striatum, OFC, and insula. Together, the study provides evidence that mGlu5 receptor availability is low in youth at elevated risk for addictions, particularly those who frequently use cannabis.

PMID: 32413893 [PubMed - as supplied by publisher]

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